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Registro Completo |
Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Solos. |
Data corrente: |
23/02/2017 |
Data da última atualização: |
10/11/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
GONZALEZ, M. H.; SILVA, C. S. da; AMARAL, C. D. B.; BIANCHI, S. R.; OLIVEIRA, L. H. B. de; COELHO, J. S.; OLIVEIRA, A.; NOGUEIRA, A. R. de A. |
Afiliação: |
Mario Henrique Gonzalez, UNESP; Caroline Santos da Silva, UFSCar; Clarice Dias Britto do Amaral, UFSCar; SILMARA ROSSANA BIANCHI, CNPS; Luciano Henrique Barca de Oliveira, UNESP; Jessica Silva Coelho, UNESP; Andrea Oliveira, UFPR; ANA RITA DE ARAUJO NOGUEIRA, CPPSE. |
Título: |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 98-105, 2017. |
DOI: |
https://doi.org/10.5935/0103-5053.20160151 |
Idioma: |
Inglês Português |
Conteúdo: |
Inorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr. |
Palavras-Chave: |
Acyclovir; Elemental impurity; Impureza elementar; Pharmaceutical product; Produto farmacêutico. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/156641/1/0103-5053-jbchs-28-01-0098.pdf
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Marc: |
LEADER 02269naa a2200277 a 4500 001 2067515 005 2021-11-10 008 2017 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.5935/0103-5053.20160151$2DOI 100 1 $aGONZALEZ, M. H. 245 $aDetermination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS.$h[electronic resource] 260 $c2017 520 $aInorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr. 653 $aAcyclovir 653 $aElemental impurity 653 $aImpureza elementar 653 $aPharmaceutical product 653 $aProduto farmacêutico 700 1 $aSILVA, C. S. da 700 1 $aAMARAL, C. D. B. 700 1 $aBIANCHI, S. R. 700 1 $aOLIVEIRA, L. H. B. de 700 1 $aCOELHO, J. S. 700 1 $aOLIVEIRA, A. 700 1 $aNOGUEIRA, A. R. de A. 773 $tJournal of the Brazilian Chemical Society$gv. 28, n. 1, p. 98-105, 2017.
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Registro original: |
Embrapa Solos (CNPS) |
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Registro Completo
Biblioteca(s): |
Embrapa Rondônia. |
Data corrente: |
03/05/1994 |
Data da última atualização: |
01/06/2012 |
Autoria: |
SOBRAL, E. S. G.; SOBRAL, C. A. M. |
Título: |
Comportamento de linhagens e cultivares de caupi (Vigna unguiculata (L. Walp.) de porte ereto, no estado de Rondonia. |
Ano de publicação: |
1984 |
Fonte/Imprenta: |
Porto Velho: EMBRAPA-UEPAE Porto Velho, 1984. |
Páginas: |
4p. |
Série: |
(EMBRAPA-UEPAE Porto Velho. Pesquisa em Andamento, 77). |
ISSN: |
0101-7039 |
Idioma: |
Português |
Conteúdo: |
O cultivo do caupi em Rondônia, é ainda de pequena expressão econômica, mas devido a severa incidência do fungo Thanatephorus cucumeris (Frank.) Donk., nas culturas do feijão comum (Phaseolus vulgaris L.) comprometendo a produção, surge o caupi como alternativa de cultivo. |
Palavras-Chave: |
Bean; Brasil; Caupi; Comportamento; Comportamento de linhagem; Cowpea; Cultivar; Cultivate; Feijao-de-corda; Lineage; Linhagens; Rondonia; Rondonia: Brasil; Variedades; Variety. |
Thesagro: |
Comportamento de Variedade; Feijão de corda; Linhagem; Vigna Unguiculata. |
Thesaurus NAL: |
Brazil; cowpeas. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/60555/1/PA-15960001.pdf
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Marc: |
LEADER 01384nam a2200409 a 4500 001 1698579 005 2012-06-01 008 1984 bl uuuu u0uu1 u #d 022 $a0101-7039 100 1 $aSOBRAL, E. S. G. 245 $aComportamento de linhagens e cultivares de caupi (Vigna unguiculata (L. Walp.) de porte ereto, no estado de Rondonia. 260 $aPorto Velho: EMBRAPA-UEPAE Porto Velho$c1984 300 $a4p. 490 $a(EMBRAPA-UEPAE Porto Velho. Pesquisa em Andamento, 77). 520 $aO cultivo do caupi em Rondônia, é ainda de pequena expressão econômica, mas devido a severa incidência do fungo Thanatephorus cucumeris (Frank.) Donk., nas culturas do feijão comum (Phaseolus vulgaris L.) comprometendo a produção, surge o caupi como alternativa de cultivo. 650 $aBrazil 650 $acowpeas 650 $aComportamento de Variedade 650 $aFeijão de corda 650 $aLinhagem 650 $aVigna Unguiculata 653 $aBean 653 $aBrasil 653 $aCaupi 653 $aComportamento 653 $aComportamento de linhagem 653 $aCowpea 653 $aCultivar 653 $aCultivate 653 $aFeijao-de-corda 653 $aLineage 653 $aLinhagens 653 $aRondonia 653 $aRondonia: Brasil 653 $aVariedades 653 $aVariety 700 1 $aSOBRAL, C. A. M.
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Embrapa Rondônia (CPAF-RO) |
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