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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Solos. |
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Data corrente: |
23/02/2017 |
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Data da última atualização: |
10/11/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GONZALEZ, M. H.; SILVA, C. S. da; AMARAL, C. D. B.; BIANCHI, S. R.; OLIVEIRA, L. H. B. de; COELHO, J. S.; OLIVEIRA, A.; NOGUEIRA, A. R. de A. |
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Afiliação: |
Mario Henrique Gonzalez, UNESP; Caroline Santos da Silva, UFSCar; Clarice Dias Britto do Amaral, UFSCar; SILMARA ROSSANA BIANCHI, CNPS; Luciano Henrique Barca de Oliveira, UNESP; Jessica Silva Coelho, UNESP; Andrea Oliveira, UFPR; ANA RITA DE ARAUJO NOGUEIRA, CPPSE. |
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Título: |
Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 98-105, 2017. |
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DOI: |
https://doi.org/10.5935/0103-5053.20160151 |
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Idioma: |
Inglês
Português |
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Conteúdo: |
Inorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr. |
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Palavras-Chave: |
Acyclovir; Elemental impurity; Impureza elementar; Pharmaceutical product; Produto farmacêutico. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/156641/1/0103-5053-jbchs-28-01-0098.pdf
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Marc: |
LEADER 02269naa a2200277 a 4500
001 2067515
005 2021-11-10
008 2017 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.5935/0103-5053.20160151$2DOI
100 1 $aGONZALEZ, M. H.
245 $aDetermination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS.$h[electronic resource]
260 $c2017
520 $aInorganic elements present in pharmaceutical products were determined by inductively coupled plasma-mass spectrometer (ICP-MS), employing microwave acid digestion as a sample preparation method. The most abundant isotopes, 75As+ , 65Cu+ , 52Cr+ , 58Ni+ , 208Pb+ , and 51V+ , were determined in acyclovir ointment and its constituents. Elemental impurities in the pharmaceutical samples were determined using an inductively coupled plasma-universal cell technology-mass spectrometer (ICP-UCT-MS) operated in kinetic energy discrimination (KED) and standard mode. The accuracy of the method was assessed by means of addition and recovery experiments. Except for Cr, spiked recoveries of the elements added to the samples before microwave acid digestion (MW-AD) step were between 95.1 and 126%, and after MW-AD step ranged from 85.6 to 132%. Limits of detection (LOD) obtained by proposed method is in agreement to those required by the U.S. Pharmacopeia Convention (USP), showing that the ICP-MS technique is well suited for quantification of these elements. The LOD's (ng L-1) for 51V+ , 52Cr+ , 58Ni+ , 65Cu+ , 75As+ and 208Pb+ in 1% v v-1 HNO3 medium were: 2.2, 81.3, 91.9, 6.9, 0.2 and 3.1, respectively. The concentration of the analytes in these samples presented a wide range, varying from 2.3 ± 0.8 µg kg-1 for As to 3446 ± 47 µg kg-1 for Cr.
653 $aAcyclovir
653 $aElemental impurity
653 $aImpureza elementar
653 $aPharmaceutical product
653 $aProduto farmacêutico
700 1 $aSILVA, C. S. da
700 1 $aAMARAL, C. D. B.
700 1 $aBIANCHI, S. R.
700 1 $aOLIVEIRA, L. H. B. de
700 1 $aCOELHO, J. S.
700 1 $aOLIVEIRA, A.
700 1 $aNOGUEIRA, A. R. de A.
773 $tJournal of the Brazilian Chemical Society$gv. 28, n. 1, p. 98-105, 2017.
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Registro original: |
Embrapa Solos (CNPS) |
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| 1. |  | GONZALEZ, M. H.; SILVA, C. S. da; AMARAL, C. D. B.; BIANCHI, S. R.; OLIVEIRA, L. H. B. de; COELHO, J. S.; OLIVEIRA, A.; NOGUEIRA, A. R. de A. Determination of elemental impurities in acyclovir ointment and raw materials using microwave acid digestion (MW-AD) and ICP-MS. Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 98-105, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Solos. |
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| Registros recuperados : 1 | |
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