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Registro Completo |
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
Data corrente: |
17/06/2016 |
Data da última atualização: |
20/03/2017 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
URBINATI, I.; STAFUZZA, N. B.; OLIVEIRA, M. T.; CHUD, T. C. S.; HIGA, R. H.; REGITANO, L. C. de A.; ALENCAR, M. M. de; BUZANSKAS, M. E.; MUNARI, D. P. |
Afiliação: |
ISMAEL URBINATI, Unesp Jaboticabal; NEDENIA BONVINO STAFUZZA, Unesp Jaboticabal; MARCOS TÚLIO OLIVEIRA, Unesp Jaboticabal; TATIANE CRISTINA SELEGUIM CHUD, Unesp Jaboticabal; ROBERTO HIROSHI HIGA, CNPTIA; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; MAURICIO MELLO DE ALENCAR, CPPSE; MARCOS ELI BUZANSKAS, Unesp Jaboticabal; DANÍSIO PRADO MUNARI, Unesp Jaboticabal. |
Título: |
Selection signatures in Canchim beef cattle |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
Journal of Animal Science and Biotechnology, v. 7, p. 1-9, 2016. |
DOI: |
10.1186/s40104-016-0089-5 |
Idioma: |
Inglês |
Notas: |
Na publicação: Luciana Correia de Almeida Regitano. |
Conteúdo: |
Background: Recent technological advances in genomics have allowed the genotyping of cattle through single nucleotide polymorphism (SNP) panels. High-density SNP panels possess greater genome coverage and are useful for the identification of conserved regions of the genome due to selection, known as selection signatures (SS). The SS are detectable by different methods, such as the extended haplotype homozygosity (EHH); and the integrated haplotype score (iHS), which is derived from the EHH. The aim of this study was to identify SS regions in Canchim cattle (composite breed), genotyped with high-density SNP panel. Results: A total of 687,655 SNP markers and 396 samples remained for SS analysis after the genotype quality control. The iHS statistic for each marker was transformed into piHS for better interpretation of the results. Chromosomes BTA5 and BTA14 showed piHS>5, with 39 and nine statistically significant SNPs (P<0.00001), respectively. For the candidate selection regions, iHS values were computed across the genome and averaged within non-overlapping windows of 500 Kb. We have identified genes that play an important role in metabolism, melanin biosynthesis (pigmentation), and embryonic and bone development. Conclusions: The observation of SS indicates that the selection processes performed in Canchim, as well as in the founder breeds (i.e. Charolais), are maintaining specific genomic regions, particularly on BTA5 and BTA14. These selection signatures regions could be associated with Canchim characterization. MenosBackground: Recent technological advances in genomics have allowed the genotyping of cattle through single nucleotide polymorphism (SNP) panels. High-density SNP panels possess greater genome coverage and are useful for the identification of conserved regions of the genome due to selection, known as selection signatures (SS). The SS are detectable by different methods, such as the extended haplotype homozygosity (EHH); and the integrated haplotype score (iHS), which is derived from the EHH. The aim of this study was to identify SS regions in Canchim cattle (composite breed), genotyped with high-density SNP panel. Results: A total of 687,655 SNP markers and 396 samples remained for SS analysis after the genotype quality control. The iHS statistic for each marker was transformed into piHS for better interpretation of the results. Chromosomes BTA5 and BTA14 showed piHS>5, with 39 and nine statistically significant SNPs (P<0.00001), respectively. For the candidate selection regions, iHS values were computed across the genome and averaged within non-overlapping windows of 500 Kb. We have identified genes that play an important role in metabolism, melanin biosynthesis (pigmentation), and embryonic and bone development. Conclusions: The observation of SS indicates that the selection processes performed in Canchim, as well as in the founder breeds (i.e. Charolais), are maintaining specific genomic regions, particularly on BTA5 and BTA14. These selection signatures regions could be a... Mostrar Tudo |
Palavras-Chave: |
Extended haplotype homozygosity; Genômica; Polimorfismo de nucleotídeo único; SNP. |
Thesagro: |
Cruzamento; Cruzamento Animal; Gado de corte; Genótipo. |
Thesaurus Nal: |
Beef cattle; Composite breeds; Genomics; Quantitative trait loci; Single nucleotide polymorphism. |
Categoria do assunto: |
G Melhoramento Genético X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/153785/1/AP-Selection-Urbinati.pdf
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/144539/1/Urbinati-JASB-2016.pdf
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Marc: |
LEADER 02707naa a2200397 a 4500 001 2061492 005 2017-03-20 008 2016 bl uuuu u00u1 u #d 024 7 $a10.1186/s40104-016-0089-5$2DOI 100 1 $aURBINATI, I. 245 $aSelection signatures in Canchim beef cattle$h[electronic resource] 260 $c2016 500 $aNa publicação: Luciana Correia de Almeida Regitano. 520 $aBackground: Recent technological advances in genomics have allowed the genotyping of cattle through single nucleotide polymorphism (SNP) panels. High-density SNP panels possess greater genome coverage and are useful for the identification of conserved regions of the genome due to selection, known as selection signatures (SS). The SS are detectable by different methods, such as the extended haplotype homozygosity (EHH); and the integrated haplotype score (iHS), which is derived from the EHH. The aim of this study was to identify SS regions in Canchim cattle (composite breed), genotyped with high-density SNP panel. Results: A total of 687,655 SNP markers and 396 samples remained for SS analysis after the genotype quality control. The iHS statistic for each marker was transformed into piHS for better interpretation of the results. Chromosomes BTA5 and BTA14 showed piHS>5, with 39 and nine statistically significant SNPs (P<0.00001), respectively. For the candidate selection regions, iHS values were computed across the genome and averaged within non-overlapping windows of 500 Kb. We have identified genes that play an important role in metabolism, melanin biosynthesis (pigmentation), and embryonic and bone development. Conclusions: The observation of SS indicates that the selection processes performed in Canchim, as well as in the founder breeds (i.e. Charolais), are maintaining specific genomic regions, particularly on BTA5 and BTA14. These selection signatures regions could be associated with Canchim characterization. 650 $aBeef cattle 650 $aComposite breeds 650 $aGenomics 650 $aQuantitative trait loci 650 $aSingle nucleotide polymorphism 650 $aCruzamento 650 $aCruzamento Animal 650 $aGado de corte 650 $aGenótipo 653 $aExtended haplotype homozygosity 653 $aGenômica 653 $aPolimorfismo de nucleotídeo único 653 $aSNP 700 1 $aSTAFUZZA, N. B. 700 1 $aOLIVEIRA, M. T. 700 1 $aCHUD, T. C. S. 700 1 $aHIGA, R. H. 700 1 $aREGITANO, L. C. de A. 700 1 $aALENCAR, M. M. de 700 1 $aBUZANSKAS, M. E. 700 1 $aMUNARI, D. P. 773 $tJournal of Animal Science and Biotechnology$gv. 7, p. 1-9, 2016.
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Embrapa Agricultura Digital (CNPTIA) |
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1. | | URBINATI, I.; STAFUZZA, N. B.; OLIVEIRA, M. T.; CHUD, T. C. S.; HIGA, R. H.; REGITANO, L. C. de A.; ALENCAR, M. M. de; BUZANSKAS, M. E.; MUNARI, D. P. Selection signatures in Canchim beef cattle Journal of Animal Science and Biotechnology, v. 7, p. 1-9, 2016. Na publicação: Luciana Correia de Almeida Regitano.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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