| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Pecuária Sul; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
|
Data corrente: |
20/04/2016 |
|
Data da última atualização: |
25/04/2024 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
ZANELLA, R.; PEIXOTO, J. de O.; CARDOSO, F. F.; CARDOSO, L. L.; BIEGELMEYER, P.; CANTAO, M. E.; OTAVIANO, A.; FREITAS, M. S.; CAETANO, A. R.; LEDUR, M. C. |
|
Afiliação: |
RICARDO ZANELLA, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; FERNANDO FLORES CARDOSO, CPPSUL; LEANDRO L. CARDOSO; PATRÍCIA BIEGELMEYER, UFPEL; MAURICIO EGIDIO CANTAO, CNPSA; ANTONIO OTAVIANO, BRF/SA; MARCELO S. FREITAS, BRF/SA; ALEXANDRE RODRIGUES CAETANO, CENARGEN; MONICA CORREA LEDUR, CNPSA. |
|
Título: |
Genetic diversity analysis of two commercial breeds of pigs using genomic and pedigree data. |
|
Ano de publicação: |
2016 |
|
Fonte/Imprenta: |
Genetics Selection Evolution, v. 48, n. 24, 30 Mar. 2016. |
|
DOI: |
10.1186/s12711-016-0203-3 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Abstract Background: Genetic improvement in livestock populations can be achieved without significantly affecting genetic diversity if mating systems and selection decisions take genetic relationships among individuals into consideration. The objective of this study was to examine the genetic diversity of two commercial breeds of pigs. Genotypes from 1168 Landrace (LA) and 1094 Large White (LW) animals from a commercial breeding program in Brazil were obtained using the Illumina PorcineSNP60 Beadchip. Inbreeding estimates based on pedigree (Fx) and genomic information using runs of homozygosity (FROH) and the single nucleotide polymorphisms (SNP) by SNP inbreeding coefficient (FSNP) were obtained. Linkage disequilibrium (LD), correlation of linkage phase (r) and effective population size (Ne) were also estimated. Results: Estimates of inbreeding obtained with pedigree information were lower than those obtained with genomic data in both breeds. We observed that the extent of LD was slightly larger at shorter distances between SNPs in the LW population than in the LA population, which indicates that the LW population was derived from a smaller Ne. Estimates of Ne based on genomic data were equal to 53 and 40 for the current populations of LA and LW, respectively. The correlation of linkage phase between the two breeds was equal to 0.77 at distances up to 50 kb, which suggests that genome-wide association and selection should be performed within breed. Although selection intensities have been stronger in the LA breed than in the LW breed, levels of genomic and pedigree inbreeding were lower for the LA than for the LW breed. Conclusions: The use of genomic data to evaluate population diversity in livestock animals can provide new and more precise insights about the effects of intense selection for production traits. Resulting information and knowledge can be used to effectively increase response to selection by appropriately managing the rate of inbreeding, minimizing negative effects of inbreeding depression and therefore maintaining desirable levels of genetic diversity. MenosAbstract Background: Genetic improvement in livestock populations can be achieved without significantly affecting genetic diversity if mating systems and selection decisions take genetic relationships among individuals into consideration. The objective of this study was to examine the genetic diversity of two commercial breeds of pigs. Genotypes from 1168 Landrace (LA) and 1094 Large White (LW) animals from a commercial breeding program in Brazil were obtained using the Illumina PorcineSNP60 Beadchip. Inbreeding estimates based on pedigree (Fx) and genomic information using runs of homozygosity (FROH) and the single nucleotide polymorphisms (SNP) by SNP inbreeding coefficient (FSNP) were obtained. Linkage disequilibrium (LD), correlation of linkage phase (r) and effective population size (Ne) were also estimated. Results: Estimates of inbreeding obtained with pedigree information were lower than those obtained with genomic data in both breeds. We observed that the extent of LD was slightly larger at shorter distances between SNPs in the LW population than in the LA population, which indicates that the LW population was derived from a smaller Ne. Estimates of Ne based on genomic data were equal to 53 and 40 for the current populations of LA and LW, respectively. The correlation of linkage phase between the two breeds was equal to 0.77 at distances up to 50 kb, which suggests that genome-wide association and selection should be performed within breed. Although selection intens... Mostrar Tudo |
|
Palavras-Chave: |
Mlhoramento genético animal. |
|
Thesagro: |
Genética animal; Raça; Suíno. |
|
Thesaurus Nal: |
Animal breeding; Swine production. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/148369/1/12711-2016-Article-203.pdf
|
|
Marc: |
LEADER 03012naa a2200313 a 4500
001 2054127
005 2024-04-25
008 2016 bl uuuu u00u1 u #d
024 7 $a10.1186/s12711-016-0203-3$2DOI
100 1 $aZANELLA, R.
245 $aGenetic diversity analysis of two commercial breeds of pigs using genomic and pedigree data.$h[electronic resource]
260 $c2016
520 $aAbstract Background: Genetic improvement in livestock populations can be achieved without significantly affecting genetic diversity if mating systems and selection decisions take genetic relationships among individuals into consideration. The objective of this study was to examine the genetic diversity of two commercial breeds of pigs. Genotypes from 1168 Landrace (LA) and 1094 Large White (LW) animals from a commercial breeding program in Brazil were obtained using the Illumina PorcineSNP60 Beadchip. Inbreeding estimates based on pedigree (Fx) and genomic information using runs of homozygosity (FROH) and the single nucleotide polymorphisms (SNP) by SNP inbreeding coefficient (FSNP) were obtained. Linkage disequilibrium (LD), correlation of linkage phase (r) and effective population size (Ne) were also estimated. Results: Estimates of inbreeding obtained with pedigree information were lower than those obtained with genomic data in both breeds. We observed that the extent of LD was slightly larger at shorter distances between SNPs in the LW population than in the LA population, which indicates that the LW population was derived from a smaller Ne. Estimates of Ne based on genomic data were equal to 53 and 40 for the current populations of LA and LW, respectively. The correlation of linkage phase between the two breeds was equal to 0.77 at distances up to 50 kb, which suggests that genome-wide association and selection should be performed within breed. Although selection intensities have been stronger in the LA breed than in the LW breed, levels of genomic and pedigree inbreeding were lower for the LA than for the LW breed. Conclusions: The use of genomic data to evaluate population diversity in livestock animals can provide new and more precise insights about the effects of intense selection for production traits. Resulting information and knowledge can be used to effectively increase response to selection by appropriately managing the rate of inbreeding, minimizing negative effects of inbreeding depression and therefore maintaining desirable levels of genetic diversity.
650 $aAnimal breeding
650 $aSwine production
650 $aGenética animal
650 $aRaça
650 $aSuíno
653 $aMlhoramento genético animal
700 1 $aPEIXOTO, J. de O.
700 1 $aCARDOSO, F. F.
700 1 $aCARDOSO, L. L.
700 1 $aBIEGELMEYER, P.
700 1 $aCANTAO, M. E.
700 1 $aOTAVIANO, A.
700 1 $aFREITAS, M. S.
700 1 $aCAETANO, A. R.
700 1 $aLEDUR, M. C.
773 $tGenetics Selection Evolution$gv. 48, n. 24, 30 Mar. 2016.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 1 | |
| 1. |  | ZANELLA, R.; PEIXOTO, J. de O.; CARDOSO, F. F.; CARDOSO, L. L.; BIEGELMEYER, P.; CANTAO, M. E.; OTAVIANO, A.; FREITAS, M. S.; CAETANO, A. R.; LEDUR, M. C. Genetic diversity analysis of two commercial breeds of pigs using genomic and pedigree data. Genetics Selection Evolution, v. 48, n. 24, 30 Mar. 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sul; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
|    |
| Registros recuperados : 1 | |
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
