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Registro Completo |
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
02/12/2015 |
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Data da última atualização: |
03/01/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SANTOS, V. S.; MARTINS FILHO, S.; RESENDE, M. D. V. de; AZEVEDO, C. F.; LOPES, P. S.; GUIMARAES, S. E. F.; GLORIA, L. S.; SILVA, F. F. |
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Afiliação: |
V. S. SANTOS, Universidade Federal de Viçosa; S. MARTINS FILHO, Universidade Federal de Viçosa; MARCOS DEON VILELA DE RESENDE, CNPF; C. F. AZEVEDO, Universidade Federal de Viçosa; P. S. LOPES, Universidade Federal de Viçosa; S. E. F. GUIMARAES, Universidade Federal de Viçosa; L. S. GLORIA, Universidade Federal de Viçosa; F. F. SILVA, Universidade Federal de Viçosa. |
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Título: |
Genomic selection for slaughter age in pigs using the Cox frailty model. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Genetics and Molecular Research, Ribeirão Preto, v. 14, n. 4, p. 12616-12627, 2015. |
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ISBN: |
http://dx.doi.org/10.4238/2015.October.19.5 |
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Idioma: |
Inglês |
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Conteúdo: |
The aim of this study was to compare genomic selection methodologies using a linear mixed model and the Cox survival model. We used data from an F2 population of pigs, in which the response variable was the time in days from birth to the culling of the animal and the covariates were 238 markers [237 single nucleotide polymorphism (SNP) plus the halothane gene]. The data were corrected for fixed effects, and the accuracy of the method was determined based on the correlation of the ranks of predicted genomic breeding values (GBVs) in both models with the corrected phenotypic values. The analysis was repeated with a subset of SNP markers with largest absolute effects. The results were in agreement with the GBV prediction and the estimation of marker effects for both models for uncensored data and for normality. However, when considering censored data, the Cox model with a normal random effect (S1) was more appropriate. Since there was no agreement between the linear mixed model and the imputed data (L2) for the prediction of genomic values and the estimation of marker effects, the model S1 was considered superior as it took into account the latent variable and the censored data. Marker selection increased correlations between the ranks of predicted GBVs by the linear and Cox frailty models and the corrected phenotypic values, and 120 markers were required to increase the predictive ability for the characteristic analyzed. |
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Palavras-Chave: |
Censured data; Dado censurado; Mixed model; Modelo mixto. |
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Thesagro: |
Polimorfismo. |
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Thesaurus Nal: |
polymorphism. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/134577/1/2015-M.Deon.GMR-Genomic.pdf
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Marc: |
LEADER 02247naa a2200277 a 4500
001 2030248
005 2018-01-03
008 2015 bl uuuu u00u1 u #d
100 1 $aSANTOS, V. S.
245 $aGenomic selection for slaughter age in pigs using the Cox frailty model.$h[electronic resource]
260 $c2015
520 $aThe aim of this study was to compare genomic selection methodologies using a linear mixed model and the Cox survival model. We used data from an F2 population of pigs, in which the response variable was the time in days from birth to the culling of the animal and the covariates were 238 markers [237 single nucleotide polymorphism (SNP) plus the halothane gene]. The data were corrected for fixed effects, and the accuracy of the method was determined based on the correlation of the ranks of predicted genomic breeding values (GBVs) in both models with the corrected phenotypic values. The analysis was repeated with a subset of SNP markers with largest absolute effects. The results were in agreement with the GBV prediction and the estimation of marker effects for both models for uncensored data and for normality. However, when considering censored data, the Cox model with a normal random effect (S1) was more appropriate. Since there was no agreement between the linear mixed model and the imputed data (L2) for the prediction of genomic values and the estimation of marker effects, the model S1 was considered superior as it took into account the latent variable and the censored data. Marker selection increased correlations between the ranks of predicted GBVs by the linear and Cox frailty models and the corrected phenotypic values, and 120 markers were required to increase the predictive ability for the characteristic analyzed.
650 $apolymorphism
650 $aPolimorfismo
653 $aCensured data
653 $aDado censurado
653 $aMixed model
653 $aModelo mixto
700 1 $aMARTINS FILHO, S.
700 1 $aRESENDE, M. D. V. de
700 1 $aAZEVEDO, C. F.
700 1 $aLOPES, P. S.
700 1 $aGUIMARAES, S. E. F.
700 1 $aGLORIA, L. S.
700 1 $aSILVA, F. F.
773 $tGenetics and Molecular Research, Ribeirão Preto$gv. 14, n. 4, p. 12616-12627, 2015.
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Embrapa Florestas (CNPF) |
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| 1. |  | SANTOS, V. S.; MARTINS FILHO, S.; RESENDE, M. D. V. de; AZEVEDO, C. F.; LOPES, P. S.; GUIMARAES, S. E. F.; GLORIA, L. S.; SILVA, F. F. Genomic selection for slaughter age in pigs using the Cox frailty model. Genetics and Molecular Research, Ribeirão Preto, v. 14, n. 4, p. 12616-12627, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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