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| 1. |  | ALVARENGA, R. C.; BORGHI, E.; GONTIJO NETO, M. M.; RESENDE, A. V. de; CALONEGO, J. C.; SILVEIRA, M. C. T. da; KARAM, D.; SIMEÃO, R. M. Agricultural productivity of a long-term crop-livestock system in the cerrado biome, Brazil. In: CONGRESSO MUNDIAL SOBRE SISTEMAS DE INTEGRAÇÃO LAVOURA-PECUÁRIA-FLORESTA, 2., 2021. Anais... Brasília, DF: Ministério da Agricultura, Pecuária e Abastecimento: Embrapa, 2021. Evento online.| Biblioteca(s): Embrapa Gado de Corte. |
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Registro Completo
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
04/03/2016 |
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Data da última atualização: |
28/04/2016 |
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Autoria: |
FERNANDO, F. S.; OKINO, C. H.; SILVA, K. R.; FERNANDES, C. C.; GONÇALVES, M. C. M.; MONTASSIER, M. F. S.; VASCONCELOS, R. O.; MONTASSIER, H. J. |
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Afiliação: |
FILIPE S. FERNANDO, FCAV/UNESP; CINTIA HIROMI OKINO, CNPSA; KETHERSON R. SILVA, FCAV/UNESP; CAMILA C. FERNANDES, FCAV/UNESP; MARIANA C. M. GONÇALVES, FCAV/UNESP; MARIA F. S. MONTASSIER, FCAV/UNESP; ROSEMERI O. VASCONCELOS, FCAV/UNESP; HELIO J. MONTASSIER, FACV/UNESP. |
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Título: |
Increased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Brasília, DF, v. 35, n. 3, p. 216-222, mar. 2015. |
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Idioma: |
Inglês |
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Conteúdo: |
A Brazilian field isolate (IBV/Brazil/PR05) of avian infectious bronchitis virus (IBV), associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as contribute to the understanding of the immunopathogenesis of IBV nephropatogenic strains. MenosA Brazilian field isolate (IBV/Brazil/PR05) of avian infectious bronchitis virus (IBV), associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as c... Mostrar Tudo |
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Palavras-Chave: |
Variant strain; Vírus da bronquite infecciosa. |
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Thesagro: |
Galinha; Nefrite. |
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Thesaurus NAL: |
Chickens; Infectious bronchitis virus; Interleukin-6; Nephritis. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/140631/1/Increased-expression.pdf
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Marc: |
LEADER 02514naa a2200301 a 4500
001 2039633
005 2016-04-28
008 2015 bl uuuu u00u1 u #d
100 1 $aFERNANDO, F. S.
245 $aIncreased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant.
260 $c2015
520 $aA Brazilian field isolate (IBV/Brazil/PR05) of avian infectious bronchitis virus (IBV), associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as contribute to the understanding of the immunopathogenesis of IBV nephropatogenic strains.
650 $aChickens
650 $aInfectious bronchitis virus
650 $aInterleukin-6
650 $aNephritis
650 $aGalinha
650 $aNefrite
653 $aVariant strain
653 $aVírus da bronquite infecciosa
700 1 $aOKINO, C. H.
700 1 $aSILVA, K. R.
700 1 $aFERNANDES, C. C.
700 1 $aGONÇALVES, M. C. M.
700 1 $aMONTASSIER, M. F. S.
700 1 $aVASCONCELOS, R. O.
700 1 $aMONTASSIER, H. J.
773 $tPesquisa Veterinária Brasileira, Brasília, DF$gv. 35, n. 3, p. 216-222, mar. 2015.
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Embrapa Unidades Centrais (AI-SEDE) |
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