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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
16/01/2014 |
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Data da última atualização: |
09/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
RODRIGUES, M. F.; ALVES, C. C. S.; FIGUEIREDO, B. B. M.; REZENDE, A. B.; WOHLRES-VIANA, S.; SILVA, V. L.; MACHADO, M. A.; TEIXEIRA, H. C. |
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Afiliação: |
MICHELE F. RODRIGUES, UFJF; CAIO C. S. ALVES, UFJF; BÁRBARA B. M. FIGUEIREDO, UFJF; ALICE B. REZENDE, UFJF; SABINE WOHLRES-VIANA, UFJF; VANIA LUCIA DA SILVA, UFJF; MARCO ANTONIO MACHADO, CNPGL; HENRIQUE C. TEIXEIRA, UFJF. |
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Título: |
Tumour necrosis factor receptors and apoptosis of alveolar macrophages during early infection with attenuaed and virulent Mycobacterium bovis. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Immunology, v. 139, n. 4, p. 503-512, 2013. |
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DOI: |
https://doi.org/10.1111%2Fimm.12097 |
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Idioma: |
Inglês |
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Conteúdo: |
Apoptosis of macrophages has been reported as an effective host strategy to control the growth of intracellular pathogens, including pathogenic mycobacteria. Tumour necrosis factor-α (TNF-α) plays an important role in the modulation of apoptosis of infected macrophages. It exerts its biological activities via two distinct cell surface receptors, TNFR1 and TNFR2, whose extracellular domain can be released by proteolysis forming soluble TNF receptors (sTNFR1 and sTNFR2). The signalling through TNFR1 initiates the majority of the biological functions of TNF-α, leading to either cell death or survival whereas TNFR2 mediates primarily survival signals. Here, the expression of TNF-α receptors and the apoptosis of alveolar macrophages were investigated during the early phase of infection with attenuated and virulent mycobacteria in mice. A significant increase of apoptosis and high expression of TNFR1 were observed in alveolar macrophages at 3 and 7 days after infection with attenuated Mycobacterium bovis but only on day 7 in infection with the virulent M. bovis. Low surface expression of TNFR1 and increased levels of sTNFR1 on day 3 after infection by the virulent strain were associated with reduced rates of apoptotic macrophages. In addition, a significant reduction in apoptosis of alveolar macrophages was observed in TNFR1−/− mice at day 3 after bacillus Calmette–Guérin infection. These results suggest a potential role for TNFR1 in mycobacteria-induced alveolar macrophage apoptosis in vivo. In this scenario, shedding of TNFR1 seems to contribute to the modulation of macrophage apoptosis in a strain-dependent manner. MenosApoptosis of macrophages has been reported as an effective host strategy to control the growth of intracellular pathogens, including pathogenic mycobacteria. Tumour necrosis factor-α (TNF-α) plays an important role in the modulation of apoptosis of infected macrophages. It exerts its biological activities via two distinct cell surface receptors, TNFR1 and TNFR2, whose extracellular domain can be released by proteolysis forming soluble TNF receptors (sTNFR1 and sTNFR2). The signalling through TNFR1 initiates the majority of the biological functions of TNF-α, leading to either cell death or survival whereas TNFR2 mediates primarily survival signals. Here, the expression of TNF-α receptors and the apoptosis of alveolar macrophages were investigated during the early phase of infection with attenuated and virulent mycobacteria in mice. A significant increase of apoptosis and high expression of TNFR1 were observed in alveolar macrophages at 3 and 7 days after infection with attenuated Mycobacterium bovis but only on day 7 in infection with the virulent M. bovis. Low surface expression of TNFR1 and increased levels of sTNFR1 on day 3 after infection by the virulent strain were associated with reduced rates of apoptotic macrophages. In addition, a significant reduction in apoptosis of alveolar macrophages was observed in TNFR1−/− mice at day 3 after bacillus Calmette–Guérin infection. These results suggest a potential role for TNFR1 in mycobacteria-induced alveolar macrophage apopto... Mostrar Tudo |
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Palavras-Chave: |
Apoptose; Macrófagos; Receptor do fator de necrose tumoral. |
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Thesagro: |
Mycobacterium Bovis. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02510naa a2200265 a 4500
001 1976421
005 2024-02-09
008 2013 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111%2Fimm.12097$2DOI
100 1 $aRODRIGUES, M. F.
245 $aTumour necrosis factor receptors and apoptosis of alveolar macrophages during early infection with attenuaed and virulent Mycobacterium bovis.$h[electronic resource]
260 $c2013
520 $aApoptosis of macrophages has been reported as an effective host strategy to control the growth of intracellular pathogens, including pathogenic mycobacteria. Tumour necrosis factor-α (TNF-α) plays an important role in the modulation of apoptosis of infected macrophages. It exerts its biological activities via two distinct cell surface receptors, TNFR1 and TNFR2, whose extracellular domain can be released by proteolysis forming soluble TNF receptors (sTNFR1 and sTNFR2). The signalling through TNFR1 initiates the majority of the biological functions of TNF-α, leading to either cell death or survival whereas TNFR2 mediates primarily survival signals. Here, the expression of TNF-α receptors and the apoptosis of alveolar macrophages were investigated during the early phase of infection with attenuated and virulent mycobacteria in mice. A significant increase of apoptosis and high expression of TNFR1 were observed in alveolar macrophages at 3 and 7 days after infection with attenuated Mycobacterium bovis but only on day 7 in infection with the virulent M. bovis. Low surface expression of TNFR1 and increased levels of sTNFR1 on day 3 after infection by the virulent strain were associated with reduced rates of apoptotic macrophages. In addition, a significant reduction in apoptosis of alveolar macrophages was observed in TNFR1−/− mice at day 3 after bacillus Calmette–Guérin infection. These results suggest a potential role for TNFR1 in mycobacteria-induced alveolar macrophage apoptosis in vivo. In this scenario, shedding of TNFR1 seems to contribute to the modulation of macrophage apoptosis in a strain-dependent manner.
650 $aMycobacterium Bovis
653 $aApoptose
653 $aMacrófagos
653 $aReceptor do fator de necrose tumoral
700 1 $aALVES, C. C. S.
700 1 $aFIGUEIREDO, B. B. M.
700 1 $aREZENDE, A. B.
700 1 $aWOHLRES-VIANA, S.
700 1 $aSILVA, V. L.
700 1 $aMACHADO, M. A.
700 1 $aTEIXEIRA, H. C.
773 $tImmunology$gv. 139, n. 4, p. 503-512, 2013.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves; Embrapa Territorial. |
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Data corrente: |
23/06/2021 |
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Data da última atualização: |
23/06/2021 |
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Tipo da produção científica: |
Documentos |
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Autoria: |
ROCHA, J. D.; FONSECA, M. F.; MIELE, M.; MIRANDA, C. R. de; MONTICELLI, C. J.; BERNARDO, E. L.; VIEIRA, G. DE. A.; PEDRÃO, R. S. |
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Afiliação: |
JOSE DILCIO ROCHA, CNPM; MARCELO FERNANDO FONSECA, CNPM; MARCELO MIELE, CNPSA; CLAUDIO ROCHA DE MIRANDA, CNPSA; CICERO JULIANO MONTICELLI, CNPSA; EDUARDO LANDO BERNARDO, Ekodata Tecnologia e Saneamento Ambiental; GABRIEL DE ANDRADE VIEIRA, Estagiário CNPM; RAFAEL SOUZA PEDRÃO, Bolsista CNPM. |
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Título: |
Inteligência territorial aplicada ao manejo de resíduos da pecuária. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Campinas, SP: Embrapa Territorial, 2021. |
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Páginas: |
49 p. |
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Série: |
(Embrapa Territorial. Documentos, 137) |
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ISSN: |
0103-7811 |
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Idioma: |
Português |
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Conteúdo: |
Este estudo integra o projeto Tecnologias para Produção e Uso de Biogás e Fertilizantes a partir do Tratamento de Dejetos Animais no Âmbito do Plano ABC11, da Rede BiogásFert, que visa oferecer para a sociedade soluções tecnológicas para a produção e o uso integrado de biogás e biofertilizantes orgânicos e organominerais a partir de dejetos animais nos diferentes sistemas de produção agropecuários, visando estratégias de desenvolvimento sustentável com foco em agricultura de baixo carbono. |
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Thesagro: |
Biodigestor; Biofertilizante; Biogás; Produção Animal. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/224005/1/5914.pdf
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Marc: |
LEADER 01289nam a2200277 a 4500
001 2132525
005 2021-06-23
008 2021 bl uuuu u0uu1 u #d
022 $a0103-7811
100 1 $aROCHA, J. D.
245 $aInteligência territorial aplicada ao manejo de resíduos da pecuária.$h[electronic resource]
260 $aCampinas, SP: Embrapa Territorial$c2021
300 $a49 p.
490 $a(Embrapa Territorial. Documentos, 137)
520 $aEste estudo integra o projeto Tecnologias para Produção e Uso de Biogás e Fertilizantes a partir do Tratamento de Dejetos Animais no Âmbito do Plano ABC11, da Rede BiogásFert, que visa oferecer para a sociedade soluções tecnológicas para a produção e o uso integrado de biogás e biofertilizantes orgânicos e organominerais a partir de dejetos animais nos diferentes sistemas de produção agropecuários, visando estratégias de desenvolvimento sustentável com foco em agricultura de baixo carbono.
650 $aBiodigestor
650 $aBiofertilizante
650 $aBiogás
650 $aProdução Animal
700 1 $aFONSECA, M. F.
700 1 $aMIELE, M.
700 1 $aMIRANDA, C. R. de
700 1 $aMONTICELLI, C. J.
700 1 $aBERNARDO, E. L.
700 1 $aVIEIRA, G. DE. A.
700 1 $aPEDRÃO, R. S.
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Embrapa Territorial (CNPM) |
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