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Registro Completo |
Biblioteca(s): |
Embrapa Cerrados. |
Data corrente: |
06/06/2023 |
Data da última atualização: |
06/06/2023 |
Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
Autoria: |
SILVA, C. G.; MARTINS, C. F. |
Afiliação: |
CAROLINA GONZALES DA SILVA; CARLOS FREDERICO MARTINS, CPAC. |
Título: |
Stem cells as nuclear donors for mammalian cloning. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
In: MOURA, M. T. (ed.). Somatic cell nuclear transfer technology. São Paulo: Humana Press, 2023. |
Páginas: |
p. 115-129 |
Série: |
(Springer. Methods in Molecular Biology, 2647). |
Idioma: |
Inglês |
Conteúdo: |
Mammals are routinely cloned by introducing somatic nuclei into enucleated oocytes. Cloning contributes to propagating desired animals, to germplasm conservation efforts, among other applications. A challenge to more broader use of this technology is the relatively low cloning efficiency, which inversely correlates with donor cell differentiation status. Emerging evidence suggests that adult multipotent stem cells improve cloning efficiency, while the greater potential of embryonic stem cells for cloning remains restricted to the mouse. The derivation of pluripotent or totipotent stem cells from livestock and wild species and their association with modulators of epigenetic marks in donor cells should increase cloning efficiency. |
Palavras-Chave: |
Células tronco; Conservação de germoplasma. |
Thesagro: |
Clone; Clone Nucelar; Mamífero. |
Categoria do assunto: |
-- |
Marc: |
LEADER 01409naa a2200217 a 4500 001 2154297 005 2023-06-06 008 2023 bl uuuu u00u1 u #d 100 1 $aSILVA, C. G. 245 $aStem cells as nuclear donors for mammalian cloning.$h[electronic resource] 260 $c2023 300 $ap. 115-129 490 $a(Springer. Methods in Molecular Biology, 2647). 520 $aMammals are routinely cloned by introducing somatic nuclei into enucleated oocytes. Cloning contributes to propagating desired animals, to germplasm conservation efforts, among other applications. A challenge to more broader use of this technology is the relatively low cloning efficiency, which inversely correlates with donor cell differentiation status. Emerging evidence suggests that adult multipotent stem cells improve cloning efficiency, while the greater potential of embryonic stem cells for cloning remains restricted to the mouse. The derivation of pluripotent or totipotent stem cells from livestock and wild species and their association with modulators of epigenetic marks in donor cells should increase cloning efficiency. 650 $aClone 650 $aClone Nucelar 650 $aMamífero 653 $aCélulas tronco 653 $aConservação de germoplasma 700 1 $aMARTINS, C. F. 773 $tIn: MOURA, M. T. (ed.). Somatic cell nuclear transfer technology. São Paulo: Humana Press, 2023.
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