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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
19/09/2022 |
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Data da última atualização: |
04/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
O'SULLIVAN, F. L. A.; SKAFTNESMO, K. O.; ANDERSSON, E.; KLEPPE, L.; EDVARDSEN, R. B.; NORBERG, B.; FJELLDAL, P. G.; HANSEN, T. J.; SCHULZ, R. W.; WARGELIUS, A. |
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Afiliação: |
FERNANDA LOUREIRO ALMEIDA OSULLIVAN, CPAA; K. O. SKAFTNESMO, Institute of Marine Research; E. ANDERSSON, Institute of Marine Research; L. KLEPPE, Institute of Marine Research; R. B. EDVARDSEN, Institute of Marine Research; B. NORBERG, Institute of Marine Research; P. G. FJELLDAL, Institute of Marine Research; T. J. HANSEN, Institute of Marine Research; R. W. SCHULZ, Institute of Marine Research; A. WARGELIUS, Institute of Marine Research. |
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Título: |
The Piwil1 N domain is required for germ cell survival in Atlantic salmon. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Frontiers in Cell and Developmental Biology, v. 10, art. 977779, 2022. |
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Idioma: |
Inglês |
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Conteúdo: |
Genetic introgression of farmed salmon into wild populations can damage the genetic integrity of wild stocks and is therefore considered as an environmental threat. One possible solution is to induce sterility in farmed salmon. We have searched for proteins potentially essential for germline survival in Atlantic salmon. One of these is the argonaute protein Piwil1, known to be required for germ cell survival. To examine Piwil1 function in salmon, we induced indels in the N domain by CRISPR-Cas9. The encoded domain is present in all vertebrate Piwi proteins and has been linked to Tdrd1 protein interaction and PAZ lobe structure. |
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Palavras-Chave: |
Argonaute protein; Fish sterility; Germline. |
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Thesaurus Nal: |
Spermatogenesis. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01429naa a2200277 a 4500
001 2146602
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008 2022 bl uuuu u00u1 u #d
100 1 $aO'SULLIVAN, F. L. A.
245 $aThe Piwil1 N domain is required for germ cell survival in Atlantic salmon.$h[electronic resource]
260 $c2022
520 $aGenetic introgression of farmed salmon into wild populations can damage the genetic integrity of wild stocks and is therefore considered as an environmental threat. One possible solution is to induce sterility in farmed salmon. We have searched for proteins potentially essential for germline survival in Atlantic salmon. One of these is the argonaute protein Piwil1, known to be required for germ cell survival. To examine Piwil1 function in salmon, we induced indels in the N domain by CRISPR-Cas9. The encoded domain is present in all vertebrate Piwi proteins and has been linked to Tdrd1 protein interaction and PAZ lobe structure.
650 $aSpermatogenesis
653 $aArgonaute protein
653 $aFish sterility
653 $aGermline
700 1 $aSKAFTNESMO, K. O.
700 1 $aANDERSSON, E.
700 1 $aKLEPPE, L.
700 1 $aEDVARDSEN, R. B.
700 1 $aNORBERG, B.
700 1 $aFJELLDAL, P. G.
700 1 $aHANSEN, T. J.
700 1 $aSCHULZ, R. W.
700 1 $aWARGELIUS, A.
773 $tFrontiers in Cell and Developmental Biology$gv. 10, art. 977779, 2022.
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