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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
21/09/2021 |
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Data da última atualização: |
10/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BERNARDO, M. P.; SILVA, B. C. R. da; MATTOSO, L. H. C. |
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Afiliação: |
LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA. |
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Título: |
Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Journal of Composite Materials, v. 55, n. 17, 2021. |
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Páginas: |
2289 - 2300 |
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ISSN: |
0021-9983 |
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DOI: |
10.1177/0021998320988568 |
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Idioma: |
Inglês |
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Conteúdo: |
Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft. |
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Palavras-Chave: |
Bone reconstruction; Green alternative; Solvent-free route. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02101naa a2200217 a 4500
001 2134648
005 2022-06-10
008 2021 bl uuuu u00u1 u #d
022 $a0021-9983
024 7 $a10.1177/0021998320988568$2DOI
100 1 $aBERNARDO, M. P.
245 $aDevelopment of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering.$h[electronic resource]
260 $c2021
300 $a2289 - 2300
520 $aInjured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft.
653 $aBone reconstruction
653 $aGreen alternative
653 $aSolvent-free route
700 1 $aSILVA, B. C. R. da
700 1 $aMATTOSO, L. H. C.
773 $tJournal of Composite Materials$gv. 55, n. 17, 2021.
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Embrapa Instrumentação (CNPDIA) |
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| Registros recuperados : 6 | |
| 1. |  | ZIELONKA, N.; MUÑOZ-SÁEZ, A.; SILVA, F. O. da; KIILL, L. H. P.; REBOUÇAS, P. O.; PEREIRA, V. S.; SIQUEIRA, K. M. M. de; CROWTHER, L.; ROJAS, N.; ARELLANO, E.; DICKS, L. Aves das fazendas. Salvador: Carvalho, 2022. 38 p. il. (Manejo sustentável de fruteiras na caatinga, 3)| Tipo: Folder/Folheto/Cartilha |
| Biblioteca(s): Embrapa Semiárido. |
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| 2. | | REBOUÇAS, P. O.; FERREIRA, V. S.; KIILL, L. H. P.; SIQUEIRA, K. M. M. de; ZIELONKA, N.; SILVA, F. O. da; MUÑOZ-SÁEZ, A.; CROWTHER, L.; ROJAS, N.; ARELLANO, E.; DICKS, L. Insetos nas fazendas. Salvador: Carvalho, 2022. 28 p. il. (Manejo sustentável de fruteiras na caatinga, 4).| Tipo: Folder/Folheto/Cartilha |
| Biblioteca(s): Embrapa Semiárido. |
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| 3. | | FERREIRA, V. S; REBOUÇAS, P. O.; KIILL, L. H. P.; SIQUEIRA, K. M. M. de; ZIELONKA, N.; SILVA, F. O.; MUÑOZ-SÁEZ, A.; CROWTHER, L.; ROJAS, N.; ARELLANO, E.; DICKS, L. Fauna do solo. Salvador: Carvalho, 2022. 31p. il. color. (Manejo sustentável de fruteiras na caatinga, 6)| Tipo: Folder/Folheto/Cartilha |
| Biblioteca(s): Embrapa Semiárido. |
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| 4. | | MUÑOZ-SÁEZ, A.; ROJAS, N.; CROWTHER, L.; ZIELONKA, N.; REBOUÇAS, P. O.; SILVA, F. O. da; FERREIRA, V. S.; SIQUEIRA, K. M. M. de; KIILL, L. H. P.; ARELLANO, E.; DICKS, L. Mamíferos nas fazendas. Salvador: Carvalho, 2022. 39 p. il (Manejo sustentável de fruteiras na caatinga, 5)| Tipo: Folder/Folheto/Cartilha |
| Biblioteca(s): Embrapa Semiárido. |
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| 5. | | SILVA, F. O. da; ARELLANO, E.; ROJAS, N.; KIILL, L. H. P.; REBOUÇAS, P. O.; FERREIRA, V. S.; SIQUEIRA, K. M. M. de; ZIELONKA, N.; MUÑOZ-SÁEZ, A.; CROWTHER, L.; DICKS, L. Práticas agrícolas de baixo impacto. Salvador: Carvalho, 2022. 30 p. il. (Manejo sustentável de fruteiras na caatinga, 1)| Tipo: Folder/Folheto/Cartilha |
| Biblioteca(s): Embrapa Semiárido. |
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| 6. | | KIILL, L. H. P.; REBOUÇAS, P. O.; FERREIRA, V. S.; SIQUEIRA, K.; ZIELONKA, N.; SILVA, F. O. da; MUNOZ-SAEZ, A.; CROWTHER, L.; ROJAS, N.; ARELLANO, E.; DICKS, L. Flora nas fazendas. Salvador: Carvalho, 2022. 24 p. il. color (Manejo sustentável de fruteiras na caatinga, 2)| Tipo: Folder/Folheto/Cartilha |
| Biblioteca(s): Embrapa Semiárido. |
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| Registros recuperados : 6 | |
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