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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
08/01/2001 |
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Data da última atualização: |
17/08/2023 |
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Autoria: |
PÉPIN, M.; PITTET, J. C.; OLIVER, M.; GOHIN, I. |
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Título: |
Cellular composition of Corynebacterium pseudotuberculosis pyogranulomas in sheep. |
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Ano de publicação: |
1994 |
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Fonte/Imprenta: |
Journal of Leukocyte Biology, v. 56, n. 5, p.666-670, Nov. 1994. |
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DOI: |
10.1002/jlb.56.5.666. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The cellular composition of 46 pyogranulomas experimentally induced with Corynebacterium pseudotuberculosis in sheep was determined by immunohistochemistry. Lesions localized in inoculation sites or draining lymph nodes consisted of macrophage and lymphocyte layers distributed around a necrotic center and surrounded by a fibrous capsule. In immature lesions, T cells of the CD4+ subset predominated, whereas in mature lesions proportions of CD8+ T lymphocytes and cells expressing the gamma/delta chains for the T cell receptor increased. Numerous pyogranuloma cells expressed the interleukin-2 receptor. In addition to these general characteristics, a large individual variability in the proportions of macrophage and T cell subsets was observed for lesions of the same age, in particular for epithelioid macrophages. This heterogeneity suggests a different cellular pattern in relation to the persistence or the elimination of bacteria by the host. |
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Palavras-Chave: |
CD4-CD8 Ratio; Composicao celular; Piogranuloma; T-Lymphocyte subsets. |
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Thesagro: |
Corynebacterium Pseudotuberculosis; Granuloma; Ovino. |
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Thesaurus Nal: |
Bacterial infections; Microbiology; Monoclonal antibodies; Sheep diseases. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 01843naa a2200301 a 4500
001 1524207
005 2023-08-17
008 1994 bl uuuu u00u1 u #d
024 7 $a10.1002/jlb.56.5.666.$2DOI
100 1 $aPÉPIN, M.
245 $aCellular composition of Corynebacterium pseudotuberculosis pyogranulomas in sheep.$h[electronic resource]
260 $c1994
520 $aAbstract: The cellular composition of 46 pyogranulomas experimentally induced with Corynebacterium pseudotuberculosis in sheep was determined by immunohistochemistry. Lesions localized in inoculation sites or draining lymph nodes consisted of macrophage and lymphocyte layers distributed around a necrotic center and surrounded by a fibrous capsule. In immature lesions, T cells of the CD4+ subset predominated, whereas in mature lesions proportions of CD8+ T lymphocytes and cells expressing the gamma/delta chains for the T cell receptor increased. Numerous pyogranuloma cells expressed the interleukin-2 receptor. In addition to these general characteristics, a large individual variability in the proportions of macrophage and T cell subsets was observed for lesions of the same age, in particular for epithelioid macrophages. This heterogeneity suggests a different cellular pattern in relation to the persistence or the elimination of bacteria by the host.
650 $aBacterial infections
650 $aMicrobiology
650 $aMonoclonal antibodies
650 $aSheep diseases
650 $aCorynebacterium Pseudotuberculosis
650 $aGranuloma
650 $aOvino
653 $aCD4-CD8 Ratio
653 $aComposicao celular
653 $aPiogranuloma
653 $aT-Lymphocyte subsets
700 1 $aPITTET, J. C.
700 1 $aOLIVER, M.
700 1 $aGOHIN, I.
773 $tJournal of Leukocyte Biology$gv. 56, n. 5, p.666-670, Nov. 1994.
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