Data/hora: 10/06/2024 09:14:44

Biblioteca(s): 	Embrapa Caprinos e Ovinos.	
Data corrente: 	08/01/2001	
Data da última atualização: 	17/08/2023	
Autoria: 	PÉPIN, M.; PITTET, J. C.; OLIVER, M.; GOHIN, I.	
Título: 	Cellular composition of Corynebacterium pseudotuberculosis pyogranulomas in sheep.	
Ano de publicação: 	1994	
Fonte/Imprenta: 	Journal of Leukocyte Biology, v. 56, n. 5, p.666-670, Nov. 1994.	
DOI: 	10.1002/jlb.56.5.666.	
Idioma: 	Inglês	
Conteúdo: 	Abstract: The cellular composition of 46 pyogranulomas experimentally induced with Corynebacterium pseudotuberculosis in sheep was determined by immunohistochemistry. Lesions localized in inoculation sites or draining lymph nodes consisted of macrophage and lymphocyte layers distributed around a necrotic center and surrounded by a fibrous capsule. In immature lesions, T cells of the CD4+ subset predominated, whereas in mature lesions proportions of CD8+ T lymphocytes and cells expressing the gamma/delta chains for the T cell receptor increased. Numerous pyogranuloma cells expressed the interleukin-2 receptor. In addition to these general characteristics, a large individual variability in the proportions of macrophage and T cell subsets was observed for lesions of the same age, in particular for epithelioid macrophages. This heterogeneity suggests a different cellular pattern in relation to the persistence or the elimination of bacteria by the host.	
Palavras-Chave: 	CD4-CD8 Ratio; Composicao celular; Piogranuloma; T-Lymphocyte subsets.	
Thesagro: 	Corynebacterium Pseudotuberculosis; Granuloma; Ovino.	
Thesaurus Nal: 	Bacterial infections; Microbiology; Monoclonal antibodies; Sheep diseases.	
Categoria do assunto: 	H Saúde e Patologia	
Registro original: 	Embrapa Caprinos e Ovinos (CNPC)	
Exemplares: 	CNPC - (10350-1) - ADD - AP - DD -  -  -  - DIS