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![](/consulta/web/img/deny.png) | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Instrumentação. |
Data corrente: |
04/05/2021 |
Data da última atualização: |
10/06/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
CHAGAS, P. A. M.; SCHNEIDER, R.; SANTOS, D. M. dos; OTUKA, A. J. G.; MENDONÇA, C. R.; CORREA, D. S. |
Afiliação: |
DANIEL SOUZA CORREA, CNPDIA. |
Título: |
Bilayered electrospun membranes composed of poly(lactic-acid)/natural rubber: A strategy against curcumin photodegradation for wound dressing application. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Reactive and Functional Polymers, v. 163, a. 104889, 2021. |
Páginas: |
1 - 11 |
ISSN: |
1381-5148 |
DOI: |
https://doi.org/10.1016/j.reactfunctpolym.2021.104889 |
Idioma: |
Inglês |
Conteúdo: |
Curcumin is a natural phenolic compound renowned for its beneficial anti-carcinogenic, anti-oxidant, antibacterial and anti-inflammatory properties. More recently, this active compound has also demonstrated wound healing capability and antibacterial properties, which are essential prerequisites to treat skin injuries. However, the practical application of curcumin in wound-healing dressing is limited by its susceptibility to photodegradation when exposed to artificial or natural sunlight. To maintain the pharmacological and antibacterial properties of curcumin and prevent its photodegradation, we have developed a bilayered asymmetric membrane for wound healing application composed of two layers of electrospun fibers. The bottom layer is composed of a biodegradable blend of poly(lactic acid)(PLA)/natural rubber(NR) microfibers containing curcumin in the bulk. In contrast, the top layer is composed solely of PLA nanofibers to simultaneously protect curcumin against photodegradation and avoid bacterial penetration. Scanning electron microscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, thermal analyses, contact angle measurements and antibacterial assay were employed to investigate the properties of the membranes. Our results demonstrated the top layer of PLA was crucial to prevent the photodegradation of curcumin contained in the PLA/NR microfibers bottom layer and also avoided the penetration of bacteria for 10 days. Additionally, the PLA/NR microfibers showed strong antibacterial activity against Staphylococcus aureus. Our results demonstrated the potential of bilayered nano/microfibrous membranes to be applied in the design of wound dressings containing active compounds susceptible to photodegradation MenosCurcumin is a natural phenolic compound renowned for its beneficial anti-carcinogenic, anti-oxidant, antibacterial and anti-inflammatory properties. More recently, this active compound has also demonstrated wound healing capability and antibacterial properties, which are essential prerequisites to treat skin injuries. However, the practical application of curcumin in wound-healing dressing is limited by its susceptibility to photodegradation when exposed to artificial or natural sunlight. To maintain the pharmacological and antibacterial properties of curcumin and prevent its photodegradation, we have developed a bilayered asymmetric membrane for wound healing application composed of two layers of electrospun fibers. The bottom layer is composed of a biodegradable blend of poly(lactic acid)(PLA)/natural rubber(NR) microfibers containing curcumin in the bulk. In contrast, the top layer is composed solely of PLA nanofibers to simultaneously protect curcumin against photodegradation and avoid bacterial penetration. Scanning electron microscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, thermal analyses, contact angle measurements and antibacterial assay were employed to investigate the properties of the membranes. Our results demonstrated the top layer of PLA was crucial to prevent the photodegradation of curcumin contained in the PLA/NR microfibers bottom layer and also avoided the penetration of bacteria for 10 days. Additionally, the PLA/NR microfibers sh... Mostrar Tudo |
Palavras-Chave: |
Bilayered membrane; Electrospinning; Polymer nanofibers; Wound dressing. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02631naa a2200265 a 4500 001 2131659 005 2022-06-10 008 2021 bl uuuu u00u1 u #d 022 $a1381-5148 024 7 $ahttps://doi.org/10.1016/j.reactfunctpolym.2021.104889$2DOI 100 1 $aCHAGAS, P. A. M. 245 $aBilayered electrospun membranes composed of poly(lactic-acid)/natural rubber$bA strategy against curcumin photodegradation for wound dressing application.$h[electronic resource] 260 $c2021 300 $a1 - 11 520 $aCurcumin is a natural phenolic compound renowned for its beneficial anti-carcinogenic, anti-oxidant, antibacterial and anti-inflammatory properties. More recently, this active compound has also demonstrated wound healing capability and antibacterial properties, which are essential prerequisites to treat skin injuries. However, the practical application of curcumin in wound-healing dressing is limited by its susceptibility to photodegradation when exposed to artificial or natural sunlight. To maintain the pharmacological and antibacterial properties of curcumin and prevent its photodegradation, we have developed a bilayered asymmetric membrane for wound healing application composed of two layers of electrospun fibers. The bottom layer is composed of a biodegradable blend of poly(lactic acid)(PLA)/natural rubber(NR) microfibers containing curcumin in the bulk. In contrast, the top layer is composed solely of PLA nanofibers to simultaneously protect curcumin against photodegradation and avoid bacterial penetration. Scanning electron microscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, thermal analyses, contact angle measurements and antibacterial assay were employed to investigate the properties of the membranes. Our results demonstrated the top layer of PLA was crucial to prevent the photodegradation of curcumin contained in the PLA/NR microfibers bottom layer and also avoided the penetration of bacteria for 10 days. Additionally, the PLA/NR microfibers showed strong antibacterial activity against Staphylococcus aureus. Our results demonstrated the potential of bilayered nano/microfibrous membranes to be applied in the design of wound dressings containing active compounds susceptible to photodegradation 653 $aBilayered membrane 653 $aElectrospinning 653 $aPolymer nanofibers 653 $aWound dressing 700 1 $aSCHNEIDER, R. 700 1 $aSANTOS, D. M. dos 700 1 $aOTUKA, A. J. G. 700 1 $aMENDONÇA, C. R. 700 1 $aCORREA, D. S. 773 $tReactive and Functional Polymers$gv. 163, a. 104889, 2021.
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3. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | BASSO, A.; MELO, G. W. B. de; FURINI, G.; SCANAGATTA, V.; BRUNETTO, G.; ADAMES, M. Avaliação da produção de morangueiro, cultivar Aromas e Oso Grande, em substratos. In: SEMINÁRIO BRASILEIRO SOBRE PEQUENAS FRUTAS, 5., 2009, Vacaria. Anais... Bento Gonçalves: Embrapa Uva e Vinho, 2009. p. 61-62.Tipo: Artigo em Anais de Congresso |
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4. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | OLIVEIRA, L. C. D.; MAJOLO, C.; BRANDÃO, F. R.; FARIAS, C. F. S.; OLIVEIRA, M. I. B.; SANTOS, W. B.; MONTEIRO, P. C.; ROCHA, M. J. S.; CHAGAS, E. C.; TAVARES-DIAS, M. Avermectins, praziquantel and levamisole have in vitro efficacy against Neoechinorhynchus buttnerae (Neoechinorhynchidae) in Colossoma macropomum: a Serrasalmidae from the Amazon. Journal of Fish Diseases, v. 42, n. 5, p. 765-772, May 2019.Tipo: Nota Técnica/Nota Científica |
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7. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | VELLOSO, J. A. R. de O.; TONELLO, J. P. Ensaio regional de linhagens de soja. In: EMBRAPA. Centro Nacional de Pesquisa de Trigo. Resultados de pesquisa em soja obtidos no Centro Nacional de Pesquisa de Trigo em 1976/77. Passo Fundo, 1977. p. 20-26 Trabalho apresentado na V Reunião Conjunta de Pesquisa de Soja da Região Sul, Pelotas, 1977.Biblioteca(s): Embrapa Trigo. |
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