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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Pecuária Sudeste. |
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Data corrente: |
26/04/2023 |
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Data da última atualização: |
11/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MATOSINHO, C. G. R.; FONSECA, P. A. de S.; PEIXOTO, M. G. C. D.; ROSSE, I. C.; LOPES, F. C. F.; ZÓZIMO, T.; VERCESI FILHO, A. E.; BRUNELI, F. A. T.; CARVALHO, M. R. S.; GAMA, M. A. S. da. |
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Afiliação: |
CAROLINA GUIMARÃES RAMOS MATOSINHO, Universidade Federal de Minas Gerais; PABLO AUGUSTO DE SOUZA FONSECA, University of Guelph; MARIA GABRIELA CAMPOLINA D PEIXOTO, CNPGL; IZINARA CRUZ ROSSE, Universidade Federal de Ouro Preto; FERNANDO CESAR FERRAZ LOPES, CNPGL; THALIA ZÓZIMO, Universidade Federal de Minas Gerais; ANÍBAL EUGÊNIO VERCESI FILHO, Instituto de Zootecnia do Governo do Estado de São Paulo; FRANK ANGELO TOMITA BRUNELI, CNPGL; MARIA RAQUEL SANTOS CARVALHO, Universidade Federal de Minas Gerais; MARCO ANTONIO SUNDFELD DA GAMA, CPPSE. |
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Título: |
Phenotypic variation in milk fatty acid composition and its association with stearoyl-CoA desaturase 1 (SCD1) gene polymorphisms in Gir cows. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Journal of Animal Breeding and Genetics, v. 140, n. 5, p. 532-548, 2023. |
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DOI: |
https://doi.org/10.1111/jbg.12777 |
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Idioma: |
Inglês |
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Conteúdo: |
Individual variation in milk fatty acid (FA) composition has been partially attrib-uted to stearoyl- CoA desaturase 1 (SCD1) gene polymorphisms in taurine breeds, but much less is known for Zebu breeds. This study investigated the phenotypic variation in milk FA composition, and the influence of SCD1 variants on this trait and on milk fat desaturase indices (DI) in Gir cows. The functional impact of SCD1 variants was predicted using bioinformatics tools. Milk and blood samples were collected from 312 cows distributed in 10 herds from five states of Brazil. SCD1 variants were identified through target sequencing, and milk FA composi-tion was determined by gas chromatography. Phenotypic variation in milk FA composition fell within the range reported for taurine breeds, with SCD18 index showing the lowest variation among the DI. Fourteen SCD1 variants were identi-fied, six of which not previously described. Regarding the A293V polymorphism, all cows were homozygous for the C allele (coding for alanine), whereas all gen-otypes were detected for the second SNP affecting the 293 codon (G > A), with compelling evidence for functional effects. Significant associations (based on raw p- values) were found between this SNP and C12:0, cis- 9, trans- 11 CLA and short- chain FA, and between another SNP (rs523411937) and C15:0 and odd- chain lin-ear FA. A new SNP on Chr26:21277069 was associated with trans- 11 C18:1, cis- 9, trans- 11 CLA, C18:3 n- 3 and n- 3 FA. These findings indicate that SCD1 polymor-phisms also contributes to the phenotypic variation in milk FA composition of Gir cows, with potential use in their breeding programmes. MenosIndividual variation in milk fatty acid (FA) composition has been partially attrib-uted to stearoyl- CoA desaturase 1 (SCD1) gene polymorphisms in taurine breeds, but much less is known for Zebu breeds. This study investigated the phenotypic variation in milk FA composition, and the influence of SCD1 variants on this trait and on milk fat desaturase indices (DI) in Gir cows. The functional impact of SCD1 variants was predicted using bioinformatics tools. Milk and blood samples were collected from 312 cows distributed in 10 herds from five states of Brazil. SCD1 variants were identified through target sequencing, and milk FA composi-tion was determined by gas chromatography. Phenotypic variation in milk FA composition fell within the range reported for taurine breeds, with SCD18 index showing the lowest variation among the DI. Fourteen SCD1 variants were identi-fied, six of which not previously described. Regarding the A293V polymorphism, all cows were homozygous for the C allele (coding for alanine), whereas all gen-otypes were detected for the second SNP affecting the 293 codon (G > A), with compelling evidence for functional effects. Significant associations (based on raw p- values) were found between this SNP and C12:0, cis- 9, trans- 11 CLA and short- chain FA, and between another SNP (rs523411937) and C15:0 and odd- chain lin-ear FA. A new SNP on Chr26:21277069 was associated with trans- 11 C18:1, cis- 9, trans- 11 CLA, C18:3 n- 3 and n- 3 FA. These findings indicate th... Mostrar Tudo |
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Palavras-Chave: |
Enzimas lipogênicas. |
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Thesagro: |
Ácido Graxo; Gado Gir; Gado Leiteiro; Gordura Láctea; Produção Leiteira; Saúde. |
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Thesaurus Nal: |
Breeds; Human health; Zebu breeds. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/255809/1/Phenotypic-variation-in-milk-fatty-acid-composition-and-its-association.pdf
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Marc: |
LEADER 02769naa a2200361 a 4500
001 2153370
005 2023-09-11
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111/jbg.12777$2DOI
100 1 $aMATOSINHO, C. G. R.
245 $aPhenotypic variation in milk fatty acid composition and its association with stearoyl-CoA desaturase 1 (SCD1) gene polymorphisms in Gir cows.$h[electronic resource]
260 $c2023
520 $aIndividual variation in milk fatty acid (FA) composition has been partially attrib-uted to stearoyl- CoA desaturase 1 (SCD1) gene polymorphisms in taurine breeds, but much less is known for Zebu breeds. This study investigated the phenotypic variation in milk FA composition, and the influence of SCD1 variants on this trait and on milk fat desaturase indices (DI) in Gir cows. The functional impact of SCD1 variants was predicted using bioinformatics tools. Milk and blood samples were collected from 312 cows distributed in 10 herds from five states of Brazil. SCD1 variants were identified through target sequencing, and milk FA composi-tion was determined by gas chromatography. Phenotypic variation in milk FA composition fell within the range reported for taurine breeds, with SCD18 index showing the lowest variation among the DI. Fourteen SCD1 variants were identi-fied, six of which not previously described. Regarding the A293V polymorphism, all cows were homozygous for the C allele (coding for alanine), whereas all gen-otypes were detected for the second SNP affecting the 293 codon (G > A), with compelling evidence for functional effects. Significant associations (based on raw p- values) were found between this SNP and C12:0, cis- 9, trans- 11 CLA and short- chain FA, and between another SNP (rs523411937) and C15:0 and odd- chain lin-ear FA. A new SNP on Chr26:21277069 was associated with trans- 11 C18:1, cis- 9, trans- 11 CLA, C18:3 n- 3 and n- 3 FA. These findings indicate that SCD1 polymor-phisms also contributes to the phenotypic variation in milk FA composition of Gir cows, with potential use in their breeding programmes.
650 $aBreeds
650 $aHuman health
650 $aZebu breeds
650 $aÁcido Graxo
650 $aGado Gir
650 $aGado Leiteiro
650 $aGordura Láctea
650 $aProdução Leiteira
650 $aSaúde
653 $aEnzimas lipogênicas
700 1 $aFONSECA, P. A. de S.
700 1 $aPEIXOTO, M. G. C. D.
700 1 $aROSSE, I. C.
700 1 $aLOPES, F. C. F.
700 1 $aZÓZIMO, T.
700 1 $aVERCESI FILHO, A. E.
700 1 $aBRUNELI, F. A. T.
700 1 $aCARVALHO, M. R. S.
700 1 $aGAMA, M. A. S. da
773 $tJournal of Animal Breeding and Genetics$gv. 140, n. 5, p. 532-548, 2023.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
07/01/2008 |
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Data da última atualização: |
25/01/2008 |
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Tipo da produção científica: |
Artigo em Anais de Congresso / Nota Técnica |
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Circulação/Nível: |
-- - -- |
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Autoria: |
CARNEIRO, A. V.; BRITO, J. R. F.; FONSECA, A. H.; STOCK, L. A.; OLIVEIRA, V. M.; ZOCCAL, R.; YAMAGUCHI, L. C. T. |
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Afiliação: |
Alziro Vasconcelos Carneiro, Embrapa Gado de Leite; José Renaldi Feitosa Brito, Embrapa Gado de Leite; A. H. Fonseca, Universidade Federal Rural do Rio de Janeiro; Lorildo Aldo Stock, Embrapa Gado de Leite; Vânia Maria de Oliveira, Embrapa Gado de Leite; Rosangela Zoccal, Embrapa Gado de Leite; Luiz Carlos Takao Yamaguchi, Embrapa Gado de Leite. |
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Título: |
Impacto econômico da mastite bovina em rebanhos leiteiros. |
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Ano de publicação: |
2007 |
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Fonte/Imprenta: |
In: CONGRESSO INTERNACIONAL DO LEITE, 6., 2007, Resende. Anais... Juiz de Fora: Embrapa Gado de Leite, 2007. 1 CD. |
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Idioma: |
Português |
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Palavras-Chave: |
leite - qualidade; rebanho leiteiro - mastite. |
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Thesagro: |
Sanidade Animal. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00678naa a2200217 a 4500
001 1595295
005 2008-01-25
008 2007 bl uuuu u00u1 u #d
100 1 $aCARNEIRO, A. V.
245 $aImpacto econômico da mastite bovina em rebanhos leiteiros.
260 $c2007
650 $aSanidade Animal
653 $aleite - qualidade
653 $arebanho leiteiro - mastite
700 1 $aBRITO, J. R. F.
700 1 $aFONSECA, A. H.
700 1 $aSTOCK, L. A.
700 1 $aOLIVEIRA, V. M.
700 1 $aZOCCAL, R.
700 1 $aYAMAGUCHI, L. C. T.
773 $tIn: CONGRESSO INTERNACIONAL DO LEITE, 6., 2007, Resende. Anais... Juiz de Fora: Embrapa Gado de Leite, 2007. 1 CD.
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Embrapa Gado de Leite (CNPGL) |
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