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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
18/05/2020 |
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Data da última atualização: |
18/05/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ALVARENGA, M. O. P.; BITTENCOURT, L. O.; MENDES, P. F. S.; RIBEIRA, J. T.; LAMEIRA, O. A.; MONTEIRO, M. C.; BARBOZA, C. A. G.; MARTINS, M. D.; LIMA, R. R. |
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Afiliação: |
María Olimpia Paz Alvarenga, UFPA; Leonardo Oliveira Bittencourt, UFPA; Paulo Fernando Santos Mendes, UFPA; Julia Turra Ribeiro, UFRGS; OSMAR ALVES LAMEIRA, CPATU; Marta Chagas Monteiro, UFPA; Carlos Augusto Galvão Barboza, UFRGS; Manoela Domingues Martins, UFRGS; Rafael Rodrigues Lima, UFPA. |
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Título: |
Safety and effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on inflammation and tissue repair of oral wounds in rats. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
International Journal of Molecular Science, v. 21, n. 10, article 3568, 2020. |
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DOI: |
https://doi.org/10.3390/ijms21103568 |
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Idioma: |
Inglês |
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Conteúdo: |
In traditional communities of the Brazilian Amazon, the copaiba oleoresin (C. reticulata Ducke) is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Our study aimed to evaluate these effects in oral lesions and the safety of the dosage proposed. A punch biopsy wound was induced on the ventral surface of the tongue of forty-five male Wistar rats under anesthesia. Animals were randomly allocated to one of three groups based on the treatment: control, corticoid and copaiba. A daily dose of each treatment and vehicle was administrated by oral gavage for three consecutive days. Sample collections took place on the third, seventh and 15th days post-wounding for clinical and histopathological analyses. Blood was collected on the third and seventh days for kidneys and liver function tests. Semi-quantitative analyses were performed based on scores of inflammation and reepithelization. Tissue collagen deposition was detected by PicroSirius red staining. Copaiba-treated wounds revealed a smaller wound area, decreased of acute inflammatory reaction and enhanced reepithelization. The levels of kidney and liver function tests did not reveal presence of damage post-treatments. Our findings suggest that copaiba oleoresin is a safe and effective alternative therapy for inflammation and tissue repair of oral wounds in this animal model. |
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Thesagro: |
Antiinflamatório; Cicatrização; Copaíba; Oleorresina; Terapia. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/213059/1/ijms-21-03568.pdf
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Marc: |
LEADER 02303naa a2200289 a 4500
001 2122369
005 2020-05-18
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/ijms21103568$2DOI
100 1 $aALVARENGA, M. O. P.
245 $aSafety and effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on inflammation and tissue repair of oral wounds in rats.$h[electronic resource]
260 $c2020
520 $aIn traditional communities of the Brazilian Amazon, the copaiba oleoresin (C. reticulata Ducke) is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Our study aimed to evaluate these effects in oral lesions and the safety of the dosage proposed. A punch biopsy wound was induced on the ventral surface of the tongue of forty-five male Wistar rats under anesthesia. Animals were randomly allocated to one of three groups based on the treatment: control, corticoid and copaiba. A daily dose of each treatment and vehicle was administrated by oral gavage for three consecutive days. Sample collections took place on the third, seventh and 15th days post-wounding for clinical and histopathological analyses. Blood was collected on the third and seventh days for kidneys and liver function tests. Semi-quantitative analyses were performed based on scores of inflammation and reepithelization. Tissue collagen deposition was detected by PicroSirius red staining. Copaiba-treated wounds revealed a smaller wound area, decreased of acute inflammatory reaction and enhanced reepithelization. The levels of kidney and liver function tests did not reveal presence of damage post-treatments. Our findings suggest that copaiba oleoresin is a safe and effective alternative therapy for inflammation and tissue repair of oral wounds in this animal model.
650 $aAntiinflamatório
650 $aCicatrização
650 $aCopaíba
650 $aOleorresina
650 $aTerapia
700 1 $aBITTENCOURT, L. O.
700 1 $aMENDES, P. F. S.
700 1 $aRIBEIRA, J. T.
700 1 $aLAMEIRA, O. A.
700 1 $aMONTEIRO, M. C.
700 1 $aBARBOZA, C. A. G.
700 1 $aMARTINS, M. D.
700 1 $aLIMA, R. R.
773 $tInternational Journal of Molecular Science$gv. 21, n. 10, article 3568, 2020.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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| 1. |  | ALVARENGA, M. O. P.; BITTENCOURT, L. O.; MENDES, P. F. S.; RIBEIRA, J. T.; LAMEIRA, O. A.; MONTEIRO, M. C.; BARBOZA, C. A. G.; MARTINS, M. D.; LIMA, R. R. Safety and effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on inflammation and tissue repair of oral wounds in rats. International Journal of Molecular Science, v. 21, n. 10, article 3568, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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