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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental; Embrapa Hortaliças. |
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Data corrente: |
14/08/2019 |
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Data da última atualização: |
03/09/2019 |
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Tipo da produção científica: |
Boletim de Pesquisa e Desenvolvimento |
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Autoria: |
MENDONCA, J. L. de; CELESTINO FILHO, P.; LOPES, C. A.; MOITA, A. W. |
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Afiliação: |
JOSE LINDORICO DE MENDONCA, CNPH; PEDRO CELESTINO FILHO, CPATU; CARLOS ALBERTO LOPES, CNPH; ANTONIO WILLIAMS MOITA, CNPH. |
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Título: |
Avaliação de jurubeba juna (Solanum stramonifolium Jacq) como porta-enxerto para tomateiro em Altamira-PA. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Brasília, DF: Embrapa Hortaliças, 2019. |
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Páginas: |
18 p. |
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Série: |
(Embrapa Hortaliças. Boletim de pesquisa e desenvolvimento, 187). |
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Idioma: |
Português |
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Conteúdo: |
O objetivo deste ensaio foi o de avaliar a jurubeba juna como porta-enxerto para tomateiro, em Altamira-PA. |
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Thesagro: |
Jurubeba; Planta Porta-Enxerto; Tomate. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/201326/1/BPD-187.pdf
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Marc: |
LEADER 00770nam a2200205 a 4500
001 2111839
005 2019-09-03
008 2019 bl uuuu u0uu1 u #d
100 1 $aMENDONCA, J. L. de
245 $aAvaliação de jurubeba juna (Solanum stramonifolium Jacq) como porta-enxerto para tomateiro em Altamira-PA.$h[electronic resource]
260 $aBrasília, DF: Embrapa Hortaliças$c2019
300 $a18 p.
490 $a(Embrapa Hortaliças. Boletim de pesquisa e desenvolvimento, 187).
520 $aO objetivo deste ensaio foi o de avaliar a jurubeba juna como porta-enxerto para tomateiro, em Altamira-PA.
650 $aJurubeba
650 $aPlanta Porta-Enxerto
650 $aTomate
700 1 $aCELESTINO FILHO, P.
700 1 $aLOPES, C. A.
700 1 $aMOITA, A. W.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
05/07/2023 |
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Data da última atualização: |
15/01/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 2 |
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Autoria: |
TEODORO, K. B. R.; ALVARENGA, A. D.; OLIVEIRA, L. F. R.; CHAGAS, P. A. M.; LOPES. R. G.; ANDRE, R. S.; MERCANTE, L. A.; ALVES, F.; STRINGASCI, M. D.; BUZZA, H. H.; INADA, N. M.; CORREA, D. S. |
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Afiliação: |
DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Fast Fabrication of Multifunctional PCL/Curcumin Nanofibrous Membranes for Wound Dressings. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
ACS Applied Bio Materials, v. 6, 2023. |
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Páginas: |
2325–2337 |
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DOI: |
https://doi.org/10.1021/acsabm.3c00177 |
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Idioma: |
Inglês |
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Conteúdo: |
herapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different environments. The biocompatibilities of PCL and PCL/CC were verified by in vitro cytotoxicity study, which demonstrated that cell viabilities average above 94 and 96% for human dermal fibroblasts. In addition, the proposed bandage responded to aPDT applied to an in vivo assay, showing that, when irritated, PCL/CC was able to reduce the bacteria present on the real wound of mice. In summary, our findings demonstrate that using PCL and CC to produce nonwovens by the SBS technique offers potential for the rapid fabrication of biocompatible and multifunctional wound dressings, paving the way for large-scale production and utilization of such dressings in the treatment of skin wounds. Menosherapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different enviro... Mostrar Tudo |
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Palavras-Chave: |
Natural dye; Optical sensor; Photodynamic therapy; Solution blow spinning; Wound dressing. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03154naa a2200337 a 4500
001 2154815
005 2024-01-15
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1021/acsabm.3c00177$2DOI
100 1 $aTEODORO, K. B. R.
245 $aFast Fabrication of Multifunctional PCL/Curcumin Nanofibrous Membranes for Wound Dressings.$h[electronic resource]
260 $c2023
300 $a2325–2337
520 $aherapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different environments. The biocompatibilities of PCL and PCL/CC were verified by in vitro cytotoxicity study, which demonstrated that cell viabilities average above 94 and 96% for human dermal fibroblasts. In addition, the proposed bandage responded to aPDT applied to an in vivo assay, showing that, when irritated, PCL/CC was able to reduce the bacteria present on the real wound of mice. In summary, our findings demonstrate that using PCL and CC to produce nonwovens by the SBS technique offers potential for the rapid fabrication of biocompatible and multifunctional wound dressings, paving the way for large-scale production and utilization of such dressings in the treatment of skin wounds.
653 $aNatural dye
653 $aOptical sensor
653 $aPhotodynamic therapy
653 $aSolution blow spinning
653 $aWound dressing
700 1 $aALVARENGA, A. D.
700 1 $aOLIVEIRA, L. F. R.
700 1 $aCHAGAS, P. A. M.
700 1 $aLOPES. R. G.
700 1 $aANDRE, R. S.
700 1 $aMERCANTE, L. A.
700 1 $aALVES, F.
700 1 $aSTRINGASCI, M. D.
700 1 $aBUZZA, H. H.
700 1 $aINADA, N. M.
700 1 $aCORREA, D. S.
773 $tACS Applied Bio Materials$gv. 6, 2023.
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