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Registro Completo |
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
18/01/2018 |
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Data da última atualização: |
29/10/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PEREIRA, M. C.; OLIVEIRA, D. A.; HILL, L. E.; ZAMBIAZI, R. C.; BORGES, C. D.; VIZZOTTO, M.; MERTENS-TALCOTT, S.; TALCOTT, S.; GOMES, C. L. |
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Afiliação: |
MARINA C. PEREIRA, UFPEL; DANIELA A. OLIVEIRA, Texas A & M Universit; LAURA E. HILL, Texas A & M Universit; RUI CARLOS ZAMBIAZI, UFPEL; CAROLINE D. BORGES, UFPEL; MARCIA VIZZOTTO, CPACT; SUSANNE MERTENS-TALCOTT, Texas A & M Universit; STEPHEN TALCOTT, Texas A & M Universit; CARMEN L. GOMES, Texas A & M Universit. |
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Título: |
Effect of nanoencapsulation using PLGA on antioxidant and antimicrobial activities of guabiroba fruit phenolic extract. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Food Chemistry, v. 240, p. 396-404, 2018. |
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Idioma: |
Inglês |
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Conteúdo: |
Guabiroba fruit has been highlighted for its high phytochemical content, particularly of phenolic compounds. The stability, bioavailability, and bioactivity of these compounds can be enhanced by nanoencapsulation, to improve functionality. Poly (D,L-lactic-co-glycolic) acid (PLGA) nanoparticles containing phenolic extract of guabiroba (GPE) were synthesized by an adapted emulsion-evaporation method and their physico-chemical and functional properties were studied at two lactic to glycolic acid ratios (50:50 and 65:35). Higher (P < 0.05) or equivalent antioxidant capacity compared to free GPE were observed for GPE-loaded nanoparticles. Free extract and PLGA nanoparticles were effective inhibitors of Listeria innocua, with lower (P < 0.05) GPE concentrations required for inhibition when nanoencapsulated. Also, reduction of ROS generation in non-cancer cells was achieved with lower GPE concentrations (P < 0.05) after encapsulation. These results suggest that PLGA nanoparticles can be used as a delivery system for phenolic compounds at lower levels than originally required for enhanced functional properties. |
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Thesagro: |
Fruta; Guabiroba. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/171341/1/nanoPLGA.pdf
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Marc: |
LEADER 01827naa a2200241 a 4500
001 2085814
005 2018-10-29
008 2018 bl uuuu u00u1 u #d
100 1 $aPEREIRA, M. C.
245 $aEffect of nanoencapsulation using PLGA on antioxidant and antimicrobial activities of guabiroba fruit phenolic extract.$h[electronic resource]
260 $c2018
520 $aGuabiroba fruit has been highlighted for its high phytochemical content, particularly of phenolic compounds. The stability, bioavailability, and bioactivity of these compounds can be enhanced by nanoencapsulation, to improve functionality. Poly (D,L-lactic-co-glycolic) acid (PLGA) nanoparticles containing phenolic extract of guabiroba (GPE) were synthesized by an adapted emulsion-evaporation method and their physico-chemical and functional properties were studied at two lactic to glycolic acid ratios (50:50 and 65:35). Higher (P < 0.05) or equivalent antioxidant capacity compared to free GPE were observed for GPE-loaded nanoparticles. Free extract and PLGA nanoparticles were effective inhibitors of Listeria innocua, with lower (P < 0.05) GPE concentrations required for inhibition when nanoencapsulated. Also, reduction of ROS generation in non-cancer cells was achieved with lower GPE concentrations (P < 0.05) after encapsulation. These results suggest that PLGA nanoparticles can be used as a delivery system for phenolic compounds at lower levels than originally required for enhanced functional properties.
650 $aFruta
650 $aGuabiroba
700 1 $aOLIVEIRA, D. A.
700 1 $aHILL, L. E.
700 1 $aZAMBIAZI, R. C.
700 1 $aBORGES, C. D.
700 1 $aVIZZOTTO, M.
700 1 $aMERTENS-TALCOTT, S.
700 1 $aTALCOTT, S.
700 1 $aGOMES, C. L.
773 $tFood Chemistry$gv. 240, p. 396-404, 2018.
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Embrapa Clima Temperado (CPACT) |
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| 1. |  | PEREIRA, M. C.; OLIVEIRA, D. A.; HILL, L. E.; ZAMBIAZI, R. C.; BORGES, C. D.; VIZZOTTO, M.; MERTENS-TALCOTT, S.; TALCOTT, S.; GOMES, C. L. Effect of nanoencapsulation using PLGA on antioxidant and antimicrobial activities of guabiroba fruit phenolic extract. Food Chemistry, v. 240, p. 396-404, 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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