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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
22/12/2015 |
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Data da última atualização: |
21/01/2020 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
FULAZ, S. F.; CABRINI, F.; TASIC, L.; BORRO, L.; NESHICH, G. |
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Afiliação: |
STEPHANIE F. FULAZ; FLÁVIA CABRINI; LJUBICA TASIC; LUIZ BORRO; GORAN NESHICH, CNPTIA. |
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Título: |
Computational biology tools in design of an agrochemical against Xyllela fastidiosa. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
In: CONGRESSO DE INICIAÇÃO CIENTIFICA DA UNICAMP, 33., 2015, Campinas. [Proceedings...]. Campinas: Unicamp, 2015. |
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Descrição Física: |
1 pôster. |
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DOI: |
10.19146/pibic-2015-38174 |
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Idioma: |
Inglês |
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Conteúdo: |
Xylella fastidiosa is a Gram-negative, non-flagellated bacterium that causes CVC in citrus and Pierce?s disease in grapevines. The CVC affects 40% of the 200 million orange trees in São Paulo state. It colonizes the xylem vessels of the plants, blocking the water and nutrient flows. PilT protein is a part of the motility system and very important for Xyllela pathogenicity and our protein target for drug design. Computational biology tools were used to design the compound able to inhibit the formation of the PilT hexamer, leading to loss of Xyllela pathogenicity. This approach could be employed in the development of new inhibitors against different targets belonging to the same protein family of PilT. |
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Palavras-Chave: |
Bioinformática; Biology; Computational biology tools; Ferramentas de biologia computacional; PilT. |
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Thesagro: |
Xylella Fastidiosa. |
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Thesaurus Nal: |
Bioinformatics. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/136081/1/computational-Fulaz-pibic.pdf
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Marc: |
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008 2015 bl uuuu u00u1 u #d
024 7 $a10.19146/pibic-2015-38174$2DOI
100 1 $aFULAZ, S. F.
245 $aComputational biology tools in design of an agrochemical against Xyllela fastidiosa.$h[electronic resource]
260 $aIn: CONGRESSO DE INICIAÇÃO CIENTIFICA DA UNICAMP, 33., 2015, Campinas. [Proceedings...]. Campinas: Unicamp$c2015
300 $c1 pôster.
520 $aXylella fastidiosa is a Gram-negative, non-flagellated bacterium that causes CVC in citrus and Pierce?s disease in grapevines. The CVC affects 40% of the 200 million orange trees in São Paulo state. It colonizes the xylem vessels of the plants, blocking the water and nutrient flows. PilT protein is a part of the motility system and very important for Xyllela pathogenicity and our protein target for drug design. Computational biology tools were used to design the compound able to inhibit the formation of the PilT hexamer, leading to loss of Xyllela pathogenicity. This approach could be employed in the development of new inhibitors against different targets belonging to the same protein family of PilT.
650 $aBioinformatics
650 $aXylella Fastidiosa
653 $aBioinformática
653 $aBiology
653 $aComputational biology tools
653 $aFerramentas de biologia computacional
653 $aPilT
700 1 $aCABRINI, F.
700 1 $aTASIC, L.
700 1 $aBORRO, L.
700 1 $aNESHICH, G.
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Embrapa Agricultura Digital (CNPTIA) |
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