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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
16/12/2014 |
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Data da última atualização: |
28/03/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BRESSANI, F. A.; TIZIOTO, P. C.; GIGLIOTI, R.; MEIRELLHES, S. L. C.; COUTINHO, R.; BENVENUTI, C. L.; MALAGO JUNIOR, W.; MUDADU, M. de A.; VIEIRA, L. C.; ZAROS, L. G.; CARRILHO, E.; REGITANO, L. C. de A. |
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Afiliação: |
FLAVIA ALINE BRESSANI, CPPSE; P. C. TIZIOTO, Universidade Federal de São Carlos; RODRIGO GIGLIOTI, Universidade Estadual Paulista; S. L. C. MEIRELLES, Universidade Federal de Lavras; R. COUTINHO, Universidade Federal do Rio Grande do Norte; C. L. BENVENUTI, Universidade Federal do Rio Grande do Norte; WILSON MALAGO JUNIOR, CPPSE; MAURICIO DE ALVARENGA MUDADU, CPPSE; LUIS CARLOS VIEIRA, CNPC; L. G. ZAROS, Universidade Federal do Rio Grande do Norte; E. CARRILHO, Universidade de São Paulo; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Single nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Genetics and Molecular Research, v. 13, n. 4, p. 8530-8436, 2014. |
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DOI: |
10.4238/2014.October.20.29 |
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Idioma: |
Inglês |
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Conteúdo: |
Cytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in goats. A population of 229 goats, F2 offspring from an F1 intercross was produced by crossing pure Saanen goats, considered as susceptible to gastrointestinal endoparasites, with pure Anglo-Nubian goats, considered resistant. Blood was collected for DNA extraction and fecal samples were also collected for parasite egg count. Polymorphisms were prospected by sequencing animals with extreme phenotype for fecal egg count (FEC) distribution. The association between SNPs and phenotype was determined by using the Fisher exact test with correction for multiple tests. Three of the 10 SNPs were identified as significant (P ≤ 0.03). They were found in intron 1 of IL2 (ENSBTA00000020883), intron 3 of IL13 (ENSBTA00000015953) and exon 3 of IFNG (ENSBTA00000012529), suggesting an association between them and gastrointestinal endoparasite resistance. Further studies will help describe the effects of these markers accurately before implementing them in marker assisted selection. This study is the pioneer in describing such associations in goats. |
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Palavras-Chave: |
Cytokine; Gastrointestinal infection. |
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Thesagro: |
Capra Hircus. |
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Thesaurus Nal: |
single nucleotide polymorphism. |
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Categoria do assunto: |
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/113908/1/PROCI-2014.00127.pdf
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Marc: |
LEADER 02372naa a2200313 a 4500
001 2002812
005 2023-03-28
008 2014 bl uuuu u00u1 u #d
024 7 $a10.4238/2014.October.20.29$2DOI
100 1 $aBRESSANI, F. A.
245 $aSingle nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats.$h[electronic resource]
260 $c2014
520 $aCytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in goats. A population of 229 goats, F2 offspring from an F1 intercross was produced by crossing pure Saanen goats, considered as susceptible to gastrointestinal endoparasites, with pure Anglo-Nubian goats, considered resistant. Blood was collected for DNA extraction and fecal samples were also collected for parasite egg count. Polymorphisms were prospected by sequencing animals with extreme phenotype for fecal egg count (FEC) distribution. The association between SNPs and phenotype was determined by using the Fisher exact test with correction for multiple tests. Three of the 10 SNPs were identified as significant (P ≤ 0.03). They were found in intron 1 of IL2 (ENSBTA00000020883), intron 3 of IL13 (ENSBTA00000015953) and exon 3 of IFNG (ENSBTA00000012529), suggesting an association between them and gastrointestinal endoparasite resistance. Further studies will help describe the effects of these markers accurately before implementing them in marker assisted selection. This study is the pioneer in describing such associations in goats.
650 $asingle nucleotide polymorphism
650 $aCapra Hircus
653 $aCytokine
653 $aGastrointestinal infection
700 1 $aTIZIOTO, P. C.
700 1 $aGIGLIOTI, R.
700 1 $aMEIRELLHES, S. L. C.
700 1 $aCOUTINHO, R.
700 1 $aBENVENUTI, C. L.
700 1 $aMALAGO JUNIOR, W.
700 1 $aMUDADU, M. de A.
700 1 $aVIEIRA, L. C.
700 1 $aZAROS, L. G.
700 1 $aCARRILHO, E.
700 1 $aREGITANO, L. C. de A.
773 $tGenetics and Molecular Research$gv. 13, n. 4, p. 8530-8436, 2014.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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| 1. |  | BRESSANI, F. A.; TIZIOTO, P. C.; GIGLIOTI, R.; MEIRELLHES, S. L. C.; COUTINHO, R.; BENVENUTI, C. L.; MALAGO JUNIOR, W.; MUDADU, M. de A.; VIEIRA, L. C.; ZAROS, L. G.; CARRILHO, E.; REGITANO, L. C. de A. Single nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats. Genetics and Molecular Research, v. 13, n. 4, p. 8530-8436, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| Registros recuperados : 1 | |
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