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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sul. |
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Data corrente: |
08/10/2020 |
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Data da última atualização: |
08/10/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CAMPOS, G. S.; SOLLERO, B. P.; REIMANN, F. A.; JUNQUEIRA, V. S.; CARDOSO, L. L.; YOKOO, M. J. I.; BOLIGON, A. A.; BRACCINI, J.; CARDOSO, F. F. |
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Afiliação: |
Gabriel Soares Campos, UFPEL; BRUNA PENA SOLLERO, CPPSUL; Fernando Antonio Reimann, UFPEL; Vinicius Silva Junqueira, UFV; Leandro Lunardini Cardoso, UFPEL; MARCOS JUN ITI YOKOO, CPPSUL; Arione Augusti Boligon, UFPEL; José Braccini, UFRGS; FERNANDO FLORES CARDOSO, CPPSUL. |
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Título: |
Tag-SNP selection using Bayesian genomewide association study for growth traits in Hereford and Braford cattle. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Journal of Animal Breeding and Genetics, v. 137, n. 5, p. 449-467, Sept. 2020. |
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DOI: |
https://doi.org/10.1111/jbg.12458 |
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Idioma: |
Inglês |
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Conteúdo: |
The aim of this study was to perform a Bayesian genomewide association study (GWAS) to identify genomic regions associated with growth traits in Hereford and Braford cattle, and to select Tag‐SNPs to represent these regions in low‐density panels useful for genomic predictions. In addition, we propose candidate genes through functional enrichment analysis associated with growth traits using Medical Subject Headings (MeSH). Phenotypic data from 126,290 animals and genotypes for 131 sires and 3,545 animals were used. The Tag‐SNPs were selected with BayesB (π = 0.995) method to compose low‐density panels. The number of Tag‐single nucleotide polymorphism (SNP) ranged between 79 and 103 SNP for the growth traits at weaning and between 78 and 100 SNP for the yearling growth traits. The average proportion of variance explained by Tag‐SNP with BayesA was 0.29, 0.23, 0.32 and 0.19 for birthweight (BW), weaning weight (WW205), yearling weight (YW550) and postweaning gain (PWG345), respectively. For Tag‐SNP with BayesA method accuracy values ranged from 0.13 to 0.30 for k‐means and from 0.30 to 0.65 for random clustering of animals to compose reference and validation groups. Although genomic prediction accuracies were higher with the full marker panel, predictions with low‐density panels retained on average 76% of the accuracy obtained with BayesB with full markers for growth traits. The MeSH analysis was able to translate genomic information providing biological meanings of more specific gene products related to the growth traits. The proposed Tag‐SNP panels may be useful for future fine mapping studies and for lower‐cost commercial genomic prediction applications. MenosThe aim of this study was to perform a Bayesian genomewide association study (GWAS) to identify genomic regions associated with growth traits in Hereford and Braford cattle, and to select Tag‐SNPs to represent these regions in low‐density panels useful for genomic predictions. In addition, we propose candidate genes through functional enrichment analysis associated with growth traits using Medical Subject Headings (MeSH). Phenotypic data from 126,290 animals and genotypes for 131 sires and 3,545 animals were used. The Tag‐SNPs were selected with BayesB (π = 0.995) method to compose low‐density panels. The number of Tag‐single nucleotide polymorphism (SNP) ranged between 79 and 103 SNP for the growth traits at weaning and between 78 and 100 SNP for the yearling growth traits. The average proportion of variance explained by Tag‐SNP with BayesA was 0.29, 0.23, 0.32 and 0.19 for birthweight (BW), weaning weight (WW205), yearling weight (YW550) and postweaning gain (PWG345), respectively. For Tag‐SNP with BayesA method accuracy values ranged from 0.13 to 0.30 for k‐means and from 0.30 to 0.65 for random clustering of animals to compose reference and validation groups. Although genomic prediction accuracies were higher with the full marker panel, predictions with low‐density panels retained on average 76% of the accuracy obtained with BayesB with full markers for growth traits. The MeSH analysis was able to translate genom... Mostrar Tudo |
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Palavras-Chave: |
Gado Braford. |
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Thesagro: |
Gado de Corte; Gado Hereford; Seleção. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02608naa a2200277 a 4500
001 2125369
005 2020-10-08
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111/jbg.12458$2DOI
100 1 $aCAMPOS, G. S.
245 $aTag-SNP selection using Bayesian genomewide association study for growth traits in Hereford and Braford cattle.$h[electronic resource]
260 $c2020
520 $aThe aim of this study was to perform a Bayesian genomewide association study (GWAS) to identify genomic regions associated with growth traits in Hereford and Braford cattle, and to select Tag‐SNPs to represent these regions in low‐density panels useful for genomic predictions. In addition, we propose candidate genes through functional enrichment analysis associated with growth traits using Medical Subject Headings (MeSH). Phenotypic data from 126,290 animals and genotypes for 131 sires and 3,545 animals were used. The Tag‐SNPs were selected with BayesB (π = 0.995) method to compose low‐density panels. The number of Tag‐single nucleotide polymorphism (SNP) ranged between 79 and 103 SNP for the growth traits at weaning and between 78 and 100 SNP for the yearling growth traits. The average proportion of variance explained by Tag‐SNP with BayesA was 0.29, 0.23, 0.32 and 0.19 for birthweight (BW), weaning weight (WW205), yearling weight (YW550) and postweaning gain (PWG345), respectively. For Tag‐SNP with BayesA method accuracy values ranged from 0.13 to 0.30 for k‐means and from 0.30 to 0.65 for random clustering of animals to compose reference and validation groups. Although genomic prediction accuracies were higher with the full marker panel, predictions with low‐density panels retained on average 76% of the accuracy obtained with BayesB with full markers for growth traits. The MeSH analysis was able to translate genomic information providing biological meanings of more specific gene products related to the growth traits. The proposed Tag‐SNP panels may be useful for future fine mapping studies and for lower‐cost commercial genomic prediction applications.
650 $aGado de Corte
650 $aGado Hereford
650 $aSeleção
653 $aGado Braford
700 1 $aSOLLERO, B. P.
700 1 $aREIMANN, F. A.
700 1 $aJUNQUEIRA, V. S.
700 1 $aCARDOSO, L. L.
700 1 $aYOKOO, M. J. I.
700 1 $aBOLIGON, A. A.
700 1 $aBRACCINI, J.
700 1 $aCARDOSO, F. F.
773 $tJournal of Animal Breeding and Genetics$gv. 137, n. 5, p. 449-467, Sept. 2020.
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Registro original: |
Embrapa Pecuária Sul (CPPSUL) |
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