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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
22/06/2016 |
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Data da última atualização: |
22/06/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, J. M. da; GIACHETTO, P. F.; SILVA, L. O. da; CINTRA, L. C.; PAIVA, S. R.; YAMAGISHI, M. E. B.; CAETANO, A. R. |
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Afiliação: |
JOAQUIM MANOEL DA SILVA, Unemat, IB/Unicamp; POLIANA FERNANDA GIACHETTO, CNPTIA; LUIZ OTAVIO CAMPOS DA SILVA, CNPGC; LEANDRO CARRIJO CINTRA, CNPTIA; SAMUEL REZENDE PAIVA, SRI; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA; ALEXANDRE RODRIGUES CAETANO, Cenargen. |
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Título: |
Genome-wide copy number variation (CNV) detection in Nelore cattle reveals highly frequent variants in genome regions harboring QTLs affecting production traits. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
BMC Genomics, London, v. 17, p. 1-14, 2016. |
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DOI: |
10.1186/s12864-016-2752-9 |
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Idioma: |
Inglês |
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Conteúdo: |
Background: Copy number variations (CNVs) have been shown to account for substantial portions of observed genomic variation and have been associated with qualitative and quantitative traits and the onset of disease in a number of species. Information from high-resolution studies to detect, characterize and estimate population-specific variant frequencies will facilitate the incorporation of CNVs in genomic studies to identify genes affecting traits of importance. Results: Genome-wide CNVs were detected in high-density single nucleotide polymorphism (SNP) genotyping data from 1,717 Nelore (Bos indicus) cattle, and in NGS data from eight key ancestral bulls. A total of 68,007 and 12,786 distinct CNVs were observed, respectively. Cross-comparisons of results obtained for the eight resequenced animals revealed that 92 % of the CNVs were observed in both datasets, while 62 % of all detected CNVs were observed to overlap with previously validated cattle copy number variant regions (CNVRs). Observed CNVs were used for obtaining breed-specific CNV frequencies and identification of CNVRs, which were subsequently used for gene annotation. A total of 688 of the detected CNVRs were observed to overlap with 286 non-redundant QTLs associated with important production traits in cattle. All of 34 CNVs previously reported to be associated with milk production traits in Holsteins were also observed in Nelore cattle. Comparisons of estimated frequencies of these CNVs in the two breeds revealed 14, 13, 6 and 14 regions in high (>20 %), low (<20 %) and divergent (NEL > HOL, NEL < HOL) frequencies, respectively. Conclusions: Obtained results significantly enriched the bovine CNV map and enabled the identification of variants that are potentially associated with traits under selection in Nelore cattle, particularly in genome regions harboring QTLs affecting production traits. MenosBackground: Copy number variations (CNVs) have been shown to account for substantial portions of observed genomic variation and have been associated with qualitative and quantitative traits and the onset of disease in a number of species. Information from high-resolution studies to detect, characterize and estimate population-specific variant frequencies will facilitate the incorporation of CNVs in genomic studies to identify genes affecting traits of importance. Results: Genome-wide CNVs were detected in high-density single nucleotide polymorphism (SNP) genotyping data from 1,717 Nelore (Bos indicus) cattle, and in NGS data from eight key ancestral bulls. A total of 68,007 and 12,786 distinct CNVs were observed, respectively. Cross-comparisons of results obtained for the eight resequenced animals revealed that 92 % of the CNVs were observed in both datasets, while 62 % of all detected CNVs were observed to overlap with previously validated cattle copy number variant regions (CNVRs). Observed CNVs were used for obtaining breed-specific CNV frequencies and identification of CNVRs, which were subsequently used for gene annotation. A total of 688 of the detected CNVRs were observed to overlap with 286 non-redundant QTLs associated with important production traits in cattle. All of 34 CNVs previously reported to be associated with milk production traits in Holsteins were also observed in Nelore cattle. Comparisons of estimated frequencies of these CNVs in the two breeds revealed... Mostrar Tudo |
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Palavras-Chave: |
Bioinformática; Copy number variations; Genotipagem; Polimorfismo de nucleotídeo único; SNP genotyping. |
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Thesagro: |
Gado de corte. |
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Thesaurus Nal: |
Beef cattle; Bioinformatics; Genotyping; High-throughput nucleotide sequencing; Single nucleotide polymorphism. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/144667/1/AP-Genome-Silva-et-al.pdf
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Marc: |
LEADER 02983naa a2200337 a 4500
001 2047683
005 2016-06-22
008 2016 bl uuuu u00u1 u #d
024 7 $a10.1186/s12864-016-2752-9$2DOI
100 1 $aSILVA, J. M. da
245 $aGenome-wide copy number variation (CNV) detection in Nelore cattle reveals highly frequent variants in genome regions harboring QTLs affecting production traits.$h[electronic resource]
260 $c2016
520 $aBackground: Copy number variations (CNVs) have been shown to account for substantial portions of observed genomic variation and have been associated with qualitative and quantitative traits and the onset of disease in a number of species. Information from high-resolution studies to detect, characterize and estimate population-specific variant frequencies will facilitate the incorporation of CNVs in genomic studies to identify genes affecting traits of importance. Results: Genome-wide CNVs were detected in high-density single nucleotide polymorphism (SNP) genotyping data from 1,717 Nelore (Bos indicus) cattle, and in NGS data from eight key ancestral bulls. A total of 68,007 and 12,786 distinct CNVs were observed, respectively. Cross-comparisons of results obtained for the eight resequenced animals revealed that 92 % of the CNVs were observed in both datasets, while 62 % of all detected CNVs were observed to overlap with previously validated cattle copy number variant regions (CNVRs). Observed CNVs were used for obtaining breed-specific CNV frequencies and identification of CNVRs, which were subsequently used for gene annotation. A total of 688 of the detected CNVRs were observed to overlap with 286 non-redundant QTLs associated with important production traits in cattle. All of 34 CNVs previously reported to be associated with milk production traits in Holsteins were also observed in Nelore cattle. Comparisons of estimated frequencies of these CNVs in the two breeds revealed 14, 13, 6 and 14 regions in high (>20 %), low (<20 %) and divergent (NEL > HOL, NEL < HOL) frequencies, respectively. Conclusions: Obtained results significantly enriched the bovine CNV map and enabled the identification of variants that are potentially associated with traits under selection in Nelore cattle, particularly in genome regions harboring QTLs affecting production traits.
650 $aBeef cattle
650 $aBioinformatics
650 $aGenotyping
650 $aHigh-throughput nucleotide sequencing
650 $aSingle nucleotide polymorphism
650 $aGado de corte
653 $aBioinformática
653 $aCopy number variations
653 $aGenotipagem
653 $aPolimorfismo de nucleotídeo único
653 $aSNP genotyping
700 1 $aGIACHETTO, P. F.
700 1 $aSILVA, L. O. da
700 1 $aCINTRA, L. C.
700 1 $aPAIVA, S. R.
700 1 $aYAMAGISHI, M. E. B.
700 1 $aCAETANO, A. R.
773 $tBMC Genomics, London$gv. 17, p. 1-14, 2016.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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| Registros recuperados : 241 | |
| 121. |  | KUSER-FALCÃO, P. R.; YAMAGISHI, M. E. B.; GIACHETTO, P. F.; SILVA, F. R.; LOBO, F. P.; CINTRA, L. C.; ZERLOTINI, A.; HIGA, R.; VIEIRA, F. Embrapa Bioinformatics Multi-Users Laboratory - LMB. In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 8., 2012, Campinas. Abstract book... Ribeirão Preto: AB3C, 2012. Não paginado. X-MEETING 2012.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 122. | | PAIXÃO, R. V.; SILVA, G. F. da; LOBO, I.; YAMAGISHI, M. E. B.; CAETANO, A. R.; VARELA, E. S.; ALMEIDA, F. L. Estrogen receptors are sex-differentially expressed in tambaqui (Colossoma macropomum) during sex differentiation. In: INTERNATIONAL SYMPOSIUM ON REPRODUCTIVE PHYSIOLOGY OF FISH, 11., 2018, Manaus. New fromtiers in reproductive diversity in a changing environment: program and abstracts. [S.l.: s.n.], 2018. p. 40. ISRPF 2018.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 123. | | PAIXÃO, R. V.; SILVA, G. F. da; LOBO, I.; YAMAGISHI, M. E. B.; CAETANO, A. R.; VARELA, E. S.; ALMEIDA, F. L. Estrogen receptors are sex-differentially expressed in tambaqui (Colossoma macropomum) during sex differentiation. In: INTERNATIONAL SYMPOSIUM ON REPRODUCTIVE PHYSIOLOGY OF FISH, 11., 2018, Manaus. p. 40.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 124. | | PAIXÃO, R. V.; SILVA, G. F.; LOBO, I.; YAMAGISHI, M. E. B.; CAETANO, A. R.; VARELA, E. S.; ALMEIDA, F. L. Estrogen receptors are sex-differentially expressed in tambaqui (Colossoma macropomum) during sex differentiation. In: INTERNATIONAL SYMPOSIUM ON REPRODUCTIVE PHYSIOLOGY OF FISH, 11., 2018, Manaus. p. 40.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pesca e Aquicultura. |
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| 125. | | GIACHETTO, P. F.; SILVA, J. M. da; SILVA, L. O. C. da; CINTRA, L. C.; PAIVA, S. R.; CAETANO, A. R.; YAMAGISHI, M. E. B. Genomic variant hotspots in nelore cattle revealed by missing genotypes. In: PLANT & ANIMAL GENOME CONFERENCE, 23., 2015, San Diego, CA. [Abstracts...]. San Diego: [s.n.], 2015. Não paginado. PAG 2015. Pôster P0289.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 126. | | SILVA, J. M. da; GIACHETTO, P. F.; SILVA, L. O. C. da; CINTRA, L. C.; PAIVA, S. R.; CAETANO, A. R.; YAMAGISHI, M. E. B. Genomic Variants Revealed by Invariably Missing Genotypes in Nelore Cattle. PLoS ONE, v. 10, n. 8, p. 1-18, 2015| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Gado de Corte; Embrapa Recursos Genéticos e Biotecnologia. |
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| 128. | | ZERLOTINI NETO, A.; LOBO, F. P.; CINTRA, L. C.; YAMAGISHI, M. E. B.; VARELA, E. S.; PAIVA, S. R.; IANELLA, P.; CAETANO, A. R. Genome sequencing and de novo assembly of the South American tiger catfish (Pseudoplatystoma Punctifer) using 10X sequencing data. In: PLANT AND ANIMAL GENOME CONFERENCE, 27., 2019, San Diego. Plant and animal genome abstracts. Livingston, NJ: Scherago, 2019. PO0249| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pesca e Aquicultura. |
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| 129. | | ZERLOTINI NETO, A.; LOBO, F. P.; CINTRA, L. C.; YAMAGISHI, M. E. B.; VARELA, E. S.; PAIVA, S. R.; IANELLA, P.; CAETANO, A. R. Genome sequencing and de novo assembly of the South American tiger catfish (Pseudoplatystoma Punctifer) using 10X sequencing data. In: PLANT AND ANIMAL GENOME CONFERENCE, 27., 2019, San Diego. Abstracts... [S.l.: s.n.], 2019. Na publicação: Adhemar Zerlotini. PAG 2019. PO0249.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Recursos Genéticos e Biotecnologia. |
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| 130. | | CAETANO, A. R.; IANELLA, P.; VARELA, E. S.; PAIVA, S. R.; LOBO, F. P.; CINTRA, L. C.; ZERLOTINI NETO, A.; YAMAGISHI, M. E. B. Genome sequencing and de novo assembly of tambaqui (Colossoma macropomum). In: AQUACULTURE, 2019, New Orleans. Aquaculture: the big choice! abstracts. [S.l.: s.n.], 2019. p. 182.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 131. | | CAETANO, A. R.; IANELLA, P.; VARELA, E. S.; PAIVA, S. R.; LOBO, F. P.; CINTRA, L. C.; ZERLOTINI NETO, A.; YAMAGISHI, M. E. B. Genome sequencing and de novo assembly of tambaqui (Colossoma macropomum). In: AQUACULTURE, 2019, New Orleans. Abstracts. [S.l.]: Word Aquaculture Society, 2019.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pesca e Aquicultura; Embrapa Recursos Genéticos e Biotecnologia. |
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| 132. | | SILVA, J. M. da; GIACHETTO, P. F.; SILVA, L. O. da; CINTRA, L. C.; PAIVA, S. R.; YAMAGISHI, M. E. B.; CAETANO, A. R. Genome-wide copy number variation (CNV) detection in Nelore cattle reveals highly frequent variants in genome regions harboring QTLs affecting production traits. BMC Genomics, London, v. 17, p. 1-14, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Recursos Genéticos e Biotecnologia. |
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| 133. | | LOBO, F. P.; YAMAGISHI, M. E. B.; CAETANO, A. R.; MCMANUS, C. M.; CARNEIRO, P. L.; FACO, O.; SOUZA, C. J. H.; PAIVA, S. R. Genetic origin of Brazilian local adapted sheep (Ovis aries) breeds by complete mitochodrial genome data analysis. In: INTERNATIONAL PLANT & ANIMAL GENOME, 21., 2013, San Diego. Abstracts... Jersey City: Scherago International, 2013. P0620.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 134. | | LOBO, F. P.; YAMAGISHI, M. E. B.; CAETANO, A. R.; MCMANUS, C. M.; CARNEIRO, P. L.; FACO, O.; SOUZA, C. J. H.; PAIVA, S. R. Genetic origin of Brazilian local adapted sheep (Ovis aries) breeds by complete mitochondrial genome data analysis. In: INTERNATIONAL PLANT & ANIMAL GENOME, 21., 2013, San Diego. [Abstracts...]. [S.l.: s.n.], 2013. Não paginado. Pôster P620.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Caprinos e Ovinos. |
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| 135. | | IBELLI, A. M. G.; HIGA, R. H.; GIACHETTO, P. F.; YAMAGISHI, M. E. B.; OLIVEIRA, M. C. S.; CARDOSO, F. F.; ALENCAR, M. M.; REGITANO, L. C. A. Genes e vias metabólicas envolvidos nos mecanismos de resistência e susceptibilidade de bovinos infestados com carrapato Rhipicephalus microplus. In: CONGRESSO BRASILEIRO DE GENÉTICA, 56., 2010, Guarujá. Resumos... Ribeirão Preto: Sociedade Brasileira de Genética, 2010. p. 74.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sul. |
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| 136. | | HERAI, R. H.; GIACHETTO, P. F.; VIEIRA, F. D.; SANTOS, E. H. dos; YAMAGISHI, M. E. B.; KUSER-FALCÃO, P. R. Detecção de erros de montagens em regiões gênicas. In: SIMPÓSIO SOBRE INOVAÇÃO E CRIATIVIDADE CIENTÍFICA NA EMBRAPA, 2., Brasília, DF, 2010. Resumos... Brasília, DF: Embrapa, 2010. Não paginado.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 137. | | SILVA, J. M. da; GIACHETTO, P. F.; SILVA, L. O. C. da; PAIVA, S. R.; CAETANO, A. R.; YAMAGISHI, M. E. B. Detection of copy number variations in nelore beef cattle with high-density SNP genotyping data. In: PLANT & ANIMAL GENOME CONFERENCE, 22., 2014, San Diego, CA. [Abstracts]. San Diego: [s.n.], 2014. Não paginado. P553.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 138. | | SILVA, J. M. da; GIACHETTO, P. F.; SILVA, L. O. C. da; PAIVA, S. R.; CAETANO, A. R.; YAMAGISHI, M. E. B. Detection of copy number variations in nelore beef cattle with high-density SNP genotyping data. In: PLANT & ANIMAL GENOME CONFERENCE, 22., 2014, San Diego, CA. [Abstracts...]. San Diego: [s.n.], 2014. Não paginado. P553.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 139. | | SILVA, N. M. L.; IANELLA, P.; YAMAGISHI, M. E. B.; PAIVA, S. R.; ROCHA, J. L.; TEIXEIRA, A. K.; FARIAS, F. G.; GUERRELHAS, A. C.; CAETANO, A. R. Development and validation of a low-density SNP panel for parentage control and evaluation of genetic diversity of pacific white shrimp (Litopenaeus vannamei). In: PLANT AND ANIMAL GENOME CONFERENCE, 27., 2019, San Diego. Abstracts... [S.l.: s.n.], 2019. PE0274. PAG 2019.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 140. | | SILVA, N. M. L.; IANELLA, P.; YAMAGISHI, M. E. B.; PAIVA, S. R.; ROCHA, J. L.; TEIXEIRA, A. K.; FARIAS, F. G.; GUERRELHAS, A. C.; CAETANO, A. R. Development and validation of a low-density SNP panel for parentage control and evaluation of genetic diversity of pacific white shrimp (Litopenaeus vannamei). In: PLANT AND ANIMAL GENOME CONFERENCE, 27., 2019, San Diego. Plant and animal genome abstracts. Livingston, NJ: Scherago, 2019. PE0274.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| Registros recuperados : 241 | |
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