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Registro Completo |
Biblioteca(s): |
Embrapa Agroenergia. |
Data corrente: |
01/10/2015 |
Data da última atualização: |
20/09/2017 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
NISHIJIMA, C. M.; DELELLA, F. K.; RODRIGUES, C. M.; RINALDO, D.; LOPES-FERREIRA, M. V. dos Anjos; ROCHA, L. R. M. da; VILEGAS, W.; FELISBINO, S. L.; HIRUMA-LIMA, C. A. |
Afiliação: |
Catarine Massucato Nishijima, UNESP; Flavia Karina Delella, UNESP; CLENILSON MARTINS RODRIGUES, CNPAE; Daniel Rinaldo, UNESP; Monica Valdyrce dos Anjos Lopes-Ferreira, Instituto Butantan; Lucia Regina Machado da Rocha, UNESP; Wagner Vilegas, UNESP; Sergio Luis Felisbino, UNESP; Clélia Akiko Hiruma-Lima, UNESP. |
Título: |
The anti-inflammatory effects of the methanolic extract and fractions from Davilla elliptica St Hil (Dilleniaceae) on Bothrops jararaca envenomation. |
Ano de publicação: |
2015 |
Fonte/Imprenta: |
International Journal of Molecular Sciences, v. 16, n. 6, 2015 |
DOI: |
10.3390/ijms160612454 |
Idioma: |
Inglês |
Conteúdo: |
Inflammation and haemorrhage are the main characteristics of tissue injury in botropic envenomation. Although some studies have shown that anti-venom prevents systemic reactions, it is not efficient in preventing tissue injury at the site of the bite. Therefore, this work was undertaken to investigate the anti-inflammatory effects of the methanolic extract and fractions from D. elliptica and to evaluate the role of matrix metalloproteinases (MMPs) in this process. Effects of the extract and fractions from D. elliptica were evaluated using a carrageenan-induced paw oedema model in rats, and leukocyte rolling was visualized by intravital. The quantification of MMPs activities (MMP-2 and MMP-9) extracted from the dermis of mice treated with extract and fractions alone or incubated with venom was determined by zymographic analyses. Our results show that intraperitoneal (i.p.) injection of fractions significantly reduced paw oedema after the carrageenan challenge. Treatment with the tannins fraction also resulted in considerable inhibition of the rolling of leukocytes and this fraction was able to decrease the activation of MMP-9. These results confirmed the anti-inflammatory activity of the methanolic extract and tannins fraction of D. elliptica and showed that the dermonecrosis properties of B. jararaca venom might be mediated through the inhibition of MMP-9 activity. |
Palavras-Chave: |
Anti-inflammatory effect; Bothrops jararaca venom; Davilla elliptica St Hil; Efeito antiinflamatório; MMP-9; MP-2; Veneno Bothrops jararaca. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02409naa a2200313 a 4500 001 2025612 005 2017-09-20 008 2015 bl uuuu u00u1 u #d 024 7 $a10.3390/ijms160612454$2DOI 100 1 $aNISHIJIMA, C. M. 245 $aThe anti-inflammatory effects of the methanolic extract and fractions from Davilla elliptica St Hil (Dilleniaceae) on Bothrops jararaca envenomation.$h[electronic resource] 260 $c2015 520 $aInflammation and haemorrhage are the main characteristics of tissue injury in botropic envenomation. Although some studies have shown that anti-venom prevents systemic reactions, it is not efficient in preventing tissue injury at the site of the bite. Therefore, this work was undertaken to investigate the anti-inflammatory effects of the methanolic extract and fractions from D. elliptica and to evaluate the role of matrix metalloproteinases (MMPs) in this process. Effects of the extract and fractions from D. elliptica were evaluated using a carrageenan-induced paw oedema model in rats, and leukocyte rolling was visualized by intravital. The quantification of MMPs activities (MMP-2 and MMP-9) extracted from the dermis of mice treated with extract and fractions alone or incubated with venom was determined by zymographic analyses. Our results show that intraperitoneal (i.p.) injection of fractions significantly reduced paw oedema after the carrageenan challenge. Treatment with the tannins fraction also resulted in considerable inhibition of the rolling of leukocytes and this fraction was able to decrease the activation of MMP-9. These results confirmed the anti-inflammatory activity of the methanolic extract and tannins fraction of D. elliptica and showed that the dermonecrosis properties of B. jararaca venom might be mediated through the inhibition of MMP-9 activity. 653 $aAnti-inflammatory effect 653 $aBothrops jararaca venom 653 $aDavilla elliptica St Hil 653 $aEfeito antiinflamatório 653 $aMMP-9 653 $aMP-2 653 $aVeneno Bothrops jararaca 700 1 $aDELELLA, F. K. 700 1 $aRODRIGUES, C. M. 700 1 $aRINALDO, D. 700 1 $aLOPES-FERREIRA, M. V. dos Anjos 700 1 $aROCHA, L. R. M. da 700 1 $aVILEGAS, W. 700 1 $aFELISBINO, S. L. 700 1 $aHIRUMA-LIMA, C. A. 773 $tInternational Journal of Molecular Sciences$gv. 16, n. 6, 2015
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Embrapa Agroenergia (CNPAE) |
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Biblioteca(s): |
Embrapa Clima Temperado. |
Data corrente: |
29/01/2013 |
Data da última atualização: |
29/01/2013 |
Tipo da produção científica: |
Artigo em Anais de Congresso |
Autoria: |
OLIVEIRA, R. J. P. de; DONINI, L. P.; FERREIRA NETO, D. T.; MAYER, K. C. de A.; SILVA, M. T. da; SILVA, S. D. dos A. e. |
Afiliação: |
Rérinton Joabél Pires de Oliveira, PPGSPAF/FAEM/UFPel; Lorena Pastorini Donini, CNPq; Domingos Tertuliano Ferreira Neto, FAEM/UFPel; Kerlley Cristina de Assis Mayer, CNPq; Mariana Teixeira da Silva; SERGIO DELMAR DOS ANJOS E SILVA, CPACT. |
Título: |
Influência de reguladores de crescimento na floração feminina e na frutificação de pinhão-manso (Jatropha curcas L.). |
Ano de publicação: |
2012 |
Fonte/Imprenta: |
In: SIMPÓSIO ESTADUAL DE AGROENERGIA, 4.; REUNIÃO TÉCNICA DE AGROENERGIA, 4., 2012, AMRIGS: Porto Alegre. Anais... Pelotas: Embrapa Clima Temperado, 2012. Organizado por Sérgio Delmar dos Anjos e Silva Ivan Rodrigues de Almeida. |
Idioma: |
Português |
Palavras-Chave: |
Pinhão-manso. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/75474/1/083.pdf
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Marc: |
LEADER 00780nam a2200169 a 4500 001 1946683 005 2013-01-29 008 2012 bl uuuu u00u1 u #d 100 1 $aOLIVEIRA, R. J. P. de 245 $aInfluência de reguladores de crescimento na floração feminina e na frutificação de pinhão-manso (Jatropha curcas L.).$h[electronic resource] 260 $aIn: SIMPÓSIO ESTADUAL DE AGROENERGIA, 4.; REUNIÃO TÉCNICA DE AGROENERGIA, 4., 2012, AMRIGS: Porto Alegre. Anais... Pelotas: Embrapa Clima Temperado, 2012. Organizado por Sérgio Delmar dos Anjos e Silva Ivan Rodrigues de Almeida.$c2012 653 $aPinhão-manso 700 1 $aDONINI, L. P. 700 1 $aFERREIRA NETO, D. T. 700 1 $aMAYER, K. C. de A. 700 1 $aSILVA, M. T. da 700 1 $aSILVA, S. D. dos A. e
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