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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
14/06/2017 |
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Data da última atualização: |
14/06/2017 |
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Autoria: |
SHAW, G.; JORGENSEN, G. I.; TWEEDALE, R.; TENNISON, M.; WATERS, M. J. |
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Título: |
Effect of epidermal growth factor on reproductive function of ewes. |
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Ano de publicação: |
1985 |
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Fonte/Imprenta: |
Journal of Endocrinology, v. 107, n. 3, p. 429-436, Dec. 1985. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Adult Merino ewes were infused via the jugular vein with either saline (n = 5) or epidermal growth factor (EGF) (4.2 micrograms/kg per h, n = 6) for 24 h in either the luteal phase or the follicular phase of the oestrous cycle and reproductive function was examined. Infusion of EGF during the luteal phase caused no detectable change in plasma progesterone or prolactin concentrations over a 7-day period compared with the controls. Infusion of EGF during the follicular phase suppressed the oestrous rise in plasma oestradiol. Luteinizing hormone pulse amplitude was increased and pulse frequency was decreased by the end of the infusion. All control ewes had a pro-oestrous LH surge and mated, but the LH surge and oestrus were prevented by EGF infusion. Nevertheless, plasma progesterone levels rose subsequently in the EGF-infused ewes in parallel with the control ewes, suggesting that the preovulatory follicle had luteinized. Both LH and FSH rose over the 7 days after EGF infusion to levels similar to those in ovariectomized ewes. Thus EGF appears to inhibit follicular oestradiol production, although it does not affect luteal progesterone production or follicular luteinization. We suggest that the alteration in gonadotrophin secretion patterns results from a disturbance of feedback mechanisms between the ovary and the hypothalamopituitary axis, although a direct effect in the brain or the pituitary gland cannot yet be excluded. |
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Palavras-Chave: |
Drug effects; Follicular Phase; LH; Luteal Phase. |
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Thesagro: |
Estradiol. |
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Thesaurus Nal: |
Blood; Epidermal growth factor; Ewes; Pharmacology; Progesterone; Reproduction; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02252naa a2200313 a 4500
001 2070945
005 2017-06-14
008 1985 bl uuuu u00u1 u #d
100 1 $aSHAW, G.
245 $aEffect of epidermal growth factor on reproductive function of ewes.
260 $c1985
520 $aAbstract: Adult Merino ewes were infused via the jugular vein with either saline (n = 5) or epidermal growth factor (EGF) (4.2 micrograms/kg per h, n = 6) for 24 h in either the luteal phase or the follicular phase of the oestrous cycle and reproductive function was examined. Infusion of EGF during the luteal phase caused no detectable change in plasma progesterone or prolactin concentrations over a 7-day period compared with the controls. Infusion of EGF during the follicular phase suppressed the oestrous rise in plasma oestradiol. Luteinizing hormone pulse amplitude was increased and pulse frequency was decreased by the end of the infusion. All control ewes had a pro-oestrous LH surge and mated, but the LH surge and oestrus were prevented by EGF infusion. Nevertheless, plasma progesterone levels rose subsequently in the EGF-infused ewes in parallel with the control ewes, suggesting that the preovulatory follicle had luteinized. Both LH and FSH rose over the 7 days after EGF infusion to levels similar to those in ovariectomized ewes. Thus EGF appears to inhibit follicular oestradiol production, although it does not affect luteal progesterone production or follicular luteinization. We suggest that the alteration in gonadotrophin secretion patterns results from a disturbance of feedback mechanisms between the ovary and the hypothalamopituitary axis, although a direct effect in the brain or the pituitary gland cannot yet be excluded.
650 $aBlood
650 $aEpidermal growth factor
650 $aEwes
650 $aPharmacology
650 $aProgesterone
650 $aReproduction
650 $aSheep
650 $aEstradiol
653 $aDrug effects
653 $aFollicular Phase
653 $aLH
653 $aLuteal Phase
700 1 $aJORGENSEN, G. I.
700 1 $aTWEEDALE, R.
700 1 $aTENNISON, M.
700 1 $aWATERS, M. J.
773 $tJournal of Endocrinology$gv. 107, n. 3, p. 429-436, Dec. 1985.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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