Data/hora: 01/06/2024 02:39:28

Biblioteca(s): | Embrapa Agricultura Digital.
Data corrente: | 01/02/2011
Data da última atualização: | 24/02/2011
Autoria: | HIGA, R. H.; TOZZI, C. L.
Afiliação: | ROBERTO HIROSHI HIGA, FEEC/UNICAMP, CNPTIA; CLÉSIO LUIS TOZZI, FEEC/UNICAMP.
Título: | Prediction of binding hot spot residues by using structural and evolutionary parameters.
Ano de publicação: | 2009
Fonte/Imprenta: | Genetics and Molecular Biology, Ribeirão Preto, v. 32, n. 3, p. 626-633, 2009.
Idioma: | Inglês
Conteúdo: | In this work, we present a method for predicting hot spot residues by using a set of structural and evolutionary parameters. Unlike previous studies, we use a set of parameters which do not depend on the structure of the protein in complex, so that the predictor can also be used when the interface region is unknown. Despite the fact that no information concerning proteins in complex is used for prediction, the application of the method to a compiled dataset described in the literature achieved a performance of 60.4%, as measured by F-Measure, corresponding to a recall of 78.1% and a precision of 49.5%. This result is higher than those reported by previous studies using the same data set.
Palavras-Chave: | Estrutura proteica; Interações proteína-proteína; Previsão de resíduos hot spots.
Thesaurus Nal: | Prediction; Protein structure.
Categoria do assunto: | W Química e Física
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/item/26210/1/gmb2009.pdf
Registro original: | Embrapa Agricultura Digital (CNPTIA)
Exemplares: | CNPTIA - (15522-1) - UPC - AP - DD -  -  -  - DIS