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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Ocidental. Para informações adicionais entre em contato com cpaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
02/12/2008 |
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Data da última atualização: |
15/05/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PINTO, A. C. S.; SILVA, L. F. R. e; CAVALCANTI, B. C.; MELO, M. R. S.; CHAVES, F. C. M.; LOTUFO, L. V. C.; MORAIS, M. O. de; ANDRADE-NETO, V. F.; TADEI, W. P.; PESSOA, C. O.; VIEIRA, P. P. R.; POHLIT, A. M. |
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Afiliação: |
Ana Cristina da Silva Pinto, UFAM; Luis Francisco Rocha e Silva, FMTAM; Bruno Coelho Cavalcanti, UFCE; Márcia Rúbia Silva Melo, INPA; FRANCISCO CELIO MAIA CHAVES, CPAA; Letícia Vera Costa Lotufo, UFCE; Manoel Odorico de Moraes, UFCE; Valter Ferreira de Andrade-Neto, Universidade Federal do Rio Grande do Norte; Wanderli Pedro Tadei, INPA; Claudia O. Pessoa, UFCE; Pedro Paulo Ribeiro Vieira, FMTAM; Adrian Martin Pohlit, INPA. |
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Título: |
New antimalarial and cytotoxic 4-nerolidylcatechol derivatives. |
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Ano de publicação: |
2009 |
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Fonte/Imprenta: |
European Journal of Medicinal Chemistry, v. 44, n. 6, p. 2731-2735, June 2009. |
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DOI: |
10.1016/j.ejmech.2008.10.025 |
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Idioma: |
Inglês |
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Conteúdo: |
4-nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multi-gram scale using straight-forward solvent extraction-column chromatography. New semisynthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,Odibenzoyl derivatives 2-8 exhibited IC50 in the 0.67?22.52 ìM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties. |
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Palavras-Chave: |
Plantas medicinais. |
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Thesagro: |
Caapeba; Câncer; Química. |
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Thesaurus Nal: |
malaria; Plasmodium falciparum. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01861naa a2200337 a 4500
001 1683881
005 2018-05-15
008 2009 bl uuuu u00u1 u #d
024 7 $a10.1016/j.ejmech.2008.10.025$2DOI
100 1 $aPINTO, A. C. S.
245 $aNew antimalarial and cytotoxic 4-nerolidylcatechol derivatives.$h[electronic resource]
260 $c2009
520 $a4-nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multi-gram scale using straight-forward solvent extraction-column chromatography. New semisynthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,Odibenzoyl derivatives 2-8 exhibited IC50 in the 0.67?22.52 ìM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties.
650 $amalaria
650 $aPlasmodium falciparum
650 $aCaapeba
650 $aCâncer
650 $aQuímica
653 $aPlantas medicinais
700 1 $aSILVA, L. F. R. e
700 1 $aCAVALCANTI, B. C.
700 1 $aMELO, M. R. S.
700 1 $aCHAVES, F. C. M.
700 1 $aLOTUFO, L. V. C.
700 1 $aMORAIS, M. O. de
700 1 $aANDRADE-NETO, V. F.
700 1 $aTADEI, W. P.
700 1 $aPESSOA, C. O.
700 1 $aVIEIRA, P. P. R.
700 1 $aPOHLIT, A. M.
773 $tEuropean Journal of Medicinal Chemistry$gv. 44, n. 6, p. 2731-2735, June 2009.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Café. |
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Data corrente: |
08/01/2018 |
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Data da última atualização: |
10/01/2018 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
CARNEIRO, F. de A.; MARRACCINI, P.; BALESTRE, M.; GRATTAPAGLIA, D.; ANDRADE, A. C. |
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Afiliação: |
Fernanda de Araújo Carneiro, Universidade Federal de Lavras; Pierre Marraccini, Cirad, UMR, DAP; Marcio Balestre, Universidade Federal de Lavras; DARIO GRATTAPAGLIA, Cenargen; ALAN CARVALHO ANDRADE, SAPC. |
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Título: |
Genomic selection in Coffea canephora. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
In: SIMPÓSIO INTERNACIONAL DE GENÉTICA E MELHORAMENTO, 8., 2017, Viçosa, MG. Ômicas: do gene ao fenótipo. [Proceedings...] Viçosa, MG: UFV, 2017. |
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Idioma: |
Inglês |
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Conteúdo: |
Coffee is one of the most heavily globally traded commodities and its production is based on Coffea arabica and Coffea canephora and Brazil being the world's largest coffee producer. It is believed that all this production will be affected due to climatic changes, with low flower viability, fruit development, yield and beverage quality. An alternative to assist in obtaining coffee plants more adapted to future climatic conditions would be genomic selection (GS). The implementation of these programs requires a lot of genetic markers, which are more readily discovered now after the reference genome of C. canephora became available. Another important factor is the high genetic variability of C. canephora, due to its level of allogamy, being of great importance for breeding programs of coffee. |
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Palavras-Chave: |
Climatic change; Coffe; Consórcio Pesquisa Café; Embrapa Cerrados; Genomic selection. |
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Thesagro: |
Coffea Arábica; Coffea Canephora. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/170556/1/Genomic-selection-in-coffea-canephora-.pdf
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Marc: |
LEADER 01571nam a2200241 a 4500
001 2084559
005 2018-01-10
008 2017 bl uuuu u00u1 u #d
100 1 $aCARNEIRO, F. de A.
245 $aGenomic selection in Coffea canephora.$h[electronic resource]
260 $aIn: SIMPÓSIO INTERNACIONAL DE GENÉTICA E MELHORAMENTO, 8., 2017, Viçosa, MG. Ômicas: do gene ao fenótipo. [Proceedings...] Viçosa, MG: UFV$c2017
520 $aCoffee is one of the most heavily globally traded commodities and its production is based on Coffea arabica and Coffea canephora and Brazil being the world's largest coffee producer. It is believed that all this production will be affected due to climatic changes, with low flower viability, fruit development, yield and beverage quality. An alternative to assist in obtaining coffee plants more adapted to future climatic conditions would be genomic selection (GS). The implementation of these programs requires a lot of genetic markers, which are more readily discovered now after the reference genome of C. canephora became available. Another important factor is the high genetic variability of C. canephora, due to its level of allogamy, being of great importance for breeding programs of coffee.
650 $aCoffea Arábica
650 $aCoffea Canephora
653 $aClimatic change
653 $aCoffe
653 $aConsórcio Pesquisa Café
653 $aEmbrapa Cerrados
653 $aGenomic selection
700 1 $aMARRACCINI, P.
700 1 $aBALESTRE, M.
700 1 $aGRATTAPAGLIA, D.
700 1 $aANDRADE, A. C.
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Embrapa Café (CNPCa) |
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