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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
03/12/2018 |
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Data da última atualização: |
24/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BARROS, P. A. V. de; ANDRADE, M. E. R.; GENEROSO, S. de V.; MIRANDA, S. E. M.; REIS, D. C. dos; LEOCÁDIO, P. C. L.; SOUZA, E. L. de S. e; MARTINS, F. dos S.; GAMA, M. A. S. da; CASSALI, G. D.; LEITE, J. I. A.; FERNANDES, S. O. A.; CARDOSO, V. N. |
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Afiliação: |
PATRÍCIA APARECIDA VIEIRA DE BARROS, UFMG; MARIA EMÍLIA RABELO ANDRADE, UFMG; SIMONE DE VASCONCELOS GENEROSO, UFMG; SUED EUSTÁQUIO MENDES MIRANDA, UFMG; DIEGO CARLOS DOS REIS, UFMG; PAOLA CAROLINE LACERDA LEOCÁDIO, UFMG; ÉRICKA LORENNA DE SALES E SOUZA, UFMG; FLAVIANO DOS SANTOS MARTINS, UFMG; MARCO ANTONIO SUNDFELD DA GAMA, CNPGL; GEOVANNI DANTAS CASSALI, UFMG; JACQUELINE ISAURA ALVAREZ LEITE, UFMG; SIMONE ODÍLIA ANTUNES FERNANDES, UFMG; VALBERT NASCIMENTO CARDOSO, UFMG. |
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Título: |
Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Biomedicine & Pharmacotherapy, v. 103, p. 1567-1576, 2018. |
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DOI: |
10.1016/j.biopha.2018.04.133 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract BACKGROUND: Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. OBJECTIVE: To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. METHODS: Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. RESULTS: Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. CONCLUSION: This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa. |
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Palavras-Chave: |
Bacterial translocation; Conjugated linoleic acids; Intestinal damage; Mucositis; Tight junction protein. |
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Thesaurus Nal: |
Cytokines. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02555naa a2200349 a 4500
001 2100591
005 2023-01-24
008 2018 bl uuuu u00u1 u #d
024 7 $a10.1016/j.biopha.2018.04.133$2DOI
100 1 $aBARROS, P. A. V. de
245 $aConjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model.$h[electronic resource]
260 $c2018
520 $aAbstract BACKGROUND: Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. OBJECTIVE: To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. METHODS: Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. RESULTS: Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. CONCLUSION: This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa.
650 $aCytokines
653 $aBacterial translocation
653 $aConjugated linoleic acids
653 $aIntestinal damage
653 $aMucositis
653 $aTight junction protein
700 1 $aANDRADE, M. E. R.
700 1 $aGENEROSO, S. de V.
700 1 $aMIRANDA, S. E. M.
700 1 $aREIS, D. C. dos
700 1 $aLEOCÁDIO, P. C. L.
700 1 $aSOUZA, E. L. de S. e
700 1 $aMARTINS, F. dos S.
700 1 $aGAMA, M. A. S. da
700 1 $aCASSALI, G. D.
700 1 $aLEITE, J. I. A.
700 1 $aFERNANDES, S. O. A.
700 1 $aCARDOSO, V. N.
773 $tBiomedicine & Pharmacotherapy$gv. 103, p. 1567-1576, 2018.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Milho e Sorgo. Para informações adicionais entre em contato com cnpms.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Algodão; Embrapa Milho e Sorgo. |
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Data corrente: |
17/11/2020 |
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Data da última atualização: |
13/10/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
CONCEIÇÃO, R. R. P. da; SIMEONE, M. L. F.; QUEIROZ, V. A. V.; MEDEIROS, E. P. de; ARAUJO, J. B. de; COUTINHO, W. M.; SILVA, D. D. da; MIGUEL, R. de A.; LANA, U. G. de P.; STOIANOFF, M. A. R. |
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Afiliação: |
Renata Regina Pereira da Conceição, Universidade Federal de Minas Gerais; MARIA LUCIA FERREIRA SIMEONE, CNPMS; VALERIA APARECIDA VIEIRA QUEIROZ, CNPMS; EVERALDO PAULO DE MEDEIROS, CNPA; JOABSON BORGES DE ARAUJO, CNPA; WIRTON MACEDO COUTINHO, CNPA; DAGMA DIONISIA DA SILVA, CNPMS; RAFAEL DE ARAUJO MIGUEL, CNPMS; UBIRACI GOMES DE PAULA LANA, CNPMS; Maria Aparecidade Resende Stoianoff, Universidade Federal de Minas Gerais. |
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Título: |
Application of Near-Infrared Hyperspectral (NIR) images combined with multivariate image analysis in the differentiation of two mycotoxicogenic Fusarium species associated with maize. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Food Chemistry, v. 344, 128615, 2021. |
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Idioma: |
Inglês |
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Conteúdo: |
Maize (Zea mays L.) is one of the most versatile crops worldwide with high socioeconomic relevance. However, mycotoxins produced by pathogenic fungi are of constant concern in maize production, as they pose serious risks to human and animal health. Thus, the search for rapid detection and/or identification methods for mycotoxins and mycotoxin-producing fungi for application in food safety remain important. In this work, we implemented use of near infrared hyperspectral images (HSI-NIR) combined with pattern recognition analysis, partial-leastsquares discriminant analysis (PLS-DA) of images, to develop a rapid method for identification of Fusarium verticillioides and F. graminearum. Validation of the HSI-NIR method and subsequent analysis was realized using 15 Fusarium spp. isolates. The method was efficient as a rapid, non-invasive, and non-destructive assessment was achieved with 100% accuracy, sensitivity, and specificity for both fungi. |
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Palavras-Chave: |
Identificação fúngica; Imagem hiperespectral. |
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Thesagro: |
Micotoxina; Zea Mays. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01865naa a2200277 a 4500
001 2126662
005 2021-10-13
008 2021 bl uuuu u00u1 u #d
100 1 $aCONCEIÇÃO, R. R. P. da
245 $aApplication of Near-Infrared Hyperspectral (NIR) images combined with multivariate image analysis in the differentiation of two mycotoxicogenic Fusarium species associated with maize.$h[electronic resource]
260 $c2021
520 $aMaize (Zea mays L.) is one of the most versatile crops worldwide with high socioeconomic relevance. However, mycotoxins produced by pathogenic fungi are of constant concern in maize production, as they pose serious risks to human and animal health. Thus, the search for rapid detection and/or identification methods for mycotoxins and mycotoxin-producing fungi for application in food safety remain important. In this work, we implemented use of near infrared hyperspectral images (HSI-NIR) combined with pattern recognition analysis, partial-leastsquares discriminant analysis (PLS-DA) of images, to develop a rapid method for identification of Fusarium verticillioides and F. graminearum. Validation of the HSI-NIR method and subsequent analysis was realized using 15 Fusarium spp. isolates. The method was efficient as a rapid, non-invasive, and non-destructive assessment was achieved with 100% accuracy, sensitivity, and specificity for both fungi.
650 $aMicotoxina
650 $aZea Mays
653 $aIdentificação fúngica
653 $aImagem hiperespectral
700 1 $aSIMEONE, M. L. F.
700 1 $aQUEIROZ, V. A. V.
700 1 $aMEDEIROS, E. P. de
700 1 $aARAUJO, J. B. de
700 1 $aCOUTINHO, W. M.
700 1 $aSILVA, D. D. da
700 1 $aMIGUEL, R. de A.
700 1 $aLANA, U. G. de P.
700 1 $aSTOIANOFF, M. A. R.
773 $tFood Chemistry$gv. 344, 128615, 2021.
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