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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
18/12/2018 |
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Data da última atualização: |
24/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OTTO, P. I.; GUIMARÃES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; VANDENPLAS, J.; SOARES, A. C. C.; SEVILLANO, C. A.; VERONEZE R; PIRES, M. de F. A.; FREITAS, C. de; PRATA, M. C. de A.; FURLONG, J.; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GOBO, D. O. R.; SILVA, M. V. G. B.; MACHADO, M. A. |
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Afiliação: |
PAMELA I. OTTO, UFV; SIMONE ELIZA FACIONI GUIMARAES, UFV; LUCAS L. VERARDO, UFV; ANA LUISA SOUSA AZEVEDO, CNPGL; J. VANDENPLAS, Wageningen University; ALINE C. C. SOARES, UFV; CLAUDIA A. SEVILLANO, Wageningen University; Topigs Norsvin Research Center, Beuningen; RENATA VERONEZE, UFV; MARIA DE FATIMA AVILA PIRES, CNPGL; CELIO DE FREITAS, CNPGL; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; JOHN FURLONG, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARTA FONSECA MARTINS, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; DIEGO O. R. GOBO, UFV; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MARCO ANTONIO MACHADO, CNPGL. |
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Título: |
Genome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle: A deeper look into this intricate mechanism. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Journal of Dairy Science, v. 101, n. 12, p. 11020-11032, 2018. |
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DOI: |
10.3168/jds.2017-14223 |
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Idioma: |
Inglês |
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Conteúdo: |
ABSTRACT Rhipicephalus (Boophilus) microplus is the main cattle ectoparasite in tropical areas. Gir × Holstein crossbred cows are well adapted to different production systems in Brazil. In this context, we performed genome-wide association study (GWAS) and post-GWAS analyses for R. microplus resistance in an experimental Gir × Holstein F2 population. Single nucleotide polymorphisms (SNP) identified in GWAS were used to build gene networks and to investigate the breed of origin for its alleles. Tick artificial infestations were performed during the dry and rainy seasons. Illumina BovineSNP50 BeadChip (Illumina Inc., San Diego, CA) and single-step BLUP procedure was used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene transcription factors networks, generated from enriched transcription factors, identified from the promoter sequences of selected gene sets. The genetic origin of marker alleles in the F2 population was assigned using the breed of origin of alleles approach. Heritability estimates for tick counts were 0.40 ± 0.11 in the rainy season and 0.54 ± 0.11 in the dry season. The top ten 0.5-Mbp windows with the highest percentage of genetic variance explained by SNP markers were found in chromosomes 10 and 23 for both the dry and rainy seasons. Gene network analyses allowed the identification of genes involved with biological processes relevant to immune system functions (TREM1, TREM2, and CD83). Gene-transcription factors network allowed the identification of genes involved with immune functions (MYO5A, TREML1, and PRSS16). In resistant animals, the average proportion of animals showing significant SNPs with paternal and maternal alleles originated from Gir breed was 44.8% whereas the proportion of animals with both paternal and maternal alleles originated from Holstein breed was 11.3%. Susceptible animals showing both paternal and maternal alleles originated from Holstein breed represented 44.6% on average, whereas both paternal and maternal alleles originated from Gir breed animals represented 9.3%. This study allowed us to identify candidate genes for tick resistance in Gir × Holstein crossbreds in both rainy and dry seasons. According to the origin of alleles analysis, we found that most animals classified as resistant showed 2 alleles from Gir breed, while the susceptible ones showed alleles from Holstein. Based on these results, the identified genes may be thoroughly investigated in additional experiments aiming to validate their effects on tick resistance phenotype in cattle. MenosABSTRACT Rhipicephalus (Boophilus) microplus is the main cattle ectoparasite in tropical areas. Gir × Holstein crossbred cows are well adapted to different production systems in Brazil. In this context, we performed genome-wide association study (GWAS) and post-GWAS analyses for R. microplus resistance in an experimental Gir × Holstein F2 population. Single nucleotide polymorphisms (SNP) identified in GWAS were used to build gene networks and to investigate the breed of origin for its alleles. Tick artificial infestations were performed during the dry and rainy seasons. Illumina BovineSNP50 BeadChip (Illumina Inc., San Diego, CA) and single-step BLUP procedure was used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene transcription factors networks, generated from enriched transcription factors, identified from the promoter sequences of selected gene sets. The genetic origin of marker alleles in the F2 population was assigned using the breed of origin of alleles approach. Heritability estimates for tick counts were 0.40 ± 0.11 in the rainy season and 0.54 ± 0.11 in the dry season. The top ten 0.5-Mbp windows with the highest percentage of genetic variance explained by SNP markers were found in chromosomes 10 and 23 for both the dry and rainy seasons. Gene network analyses allowed the identification of genes involved with biological processes relevant to immune system functions (TREM1, TREM2, and CD83). Gene-transcription factors network a... Mostrar Tudo |
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Palavras-Chave: |
Breed of origin; Gene network; Gir × Holstein crossbred. |
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Thesaurus Nal: |
Genetic variance. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 03793naa a2200397 a 4500
001 2101869
005 2023-01-24
008 2018 bl uuuu u00u1 u #d
024 7 $a10.3168/jds.2017-14223$2DOI
100 1 $aOTTO, P. I.
245 $aGenome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle$bA deeper look into this intricate mechanism.$h[electronic resource]
260 $c2018
520 $aABSTRACT Rhipicephalus (Boophilus) microplus is the main cattle ectoparasite in tropical areas. Gir × Holstein crossbred cows are well adapted to different production systems in Brazil. In this context, we performed genome-wide association study (GWAS) and post-GWAS analyses for R. microplus resistance in an experimental Gir × Holstein F2 population. Single nucleotide polymorphisms (SNP) identified in GWAS were used to build gene networks and to investigate the breed of origin for its alleles. Tick artificial infestations were performed during the dry and rainy seasons. Illumina BovineSNP50 BeadChip (Illumina Inc., San Diego, CA) and single-step BLUP procedure was used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene transcription factors networks, generated from enriched transcription factors, identified from the promoter sequences of selected gene sets. The genetic origin of marker alleles in the F2 population was assigned using the breed of origin of alleles approach. Heritability estimates for tick counts were 0.40 ± 0.11 in the rainy season and 0.54 ± 0.11 in the dry season. The top ten 0.5-Mbp windows with the highest percentage of genetic variance explained by SNP markers were found in chromosomes 10 and 23 for both the dry and rainy seasons. Gene network analyses allowed the identification of genes involved with biological processes relevant to immune system functions (TREM1, TREM2, and CD83). Gene-transcription factors network allowed the identification of genes involved with immune functions (MYO5A, TREML1, and PRSS16). In resistant animals, the average proportion of animals showing significant SNPs with paternal and maternal alleles originated from Gir breed was 44.8% whereas the proportion of animals with both paternal and maternal alleles originated from Holstein breed was 11.3%. Susceptible animals showing both paternal and maternal alleles originated from Holstein breed represented 44.6% on average, whereas both paternal and maternal alleles originated from Gir breed animals represented 9.3%. This study allowed us to identify candidate genes for tick resistance in Gir × Holstein crossbreds in both rainy and dry seasons. According to the origin of alleles analysis, we found that most animals classified as resistant showed 2 alleles from Gir breed, while the susceptible ones showed alleles from Holstein. Based on these results, the identified genes may be thoroughly investigated in additional experiments aiming to validate their effects on tick resistance phenotype in cattle.
650 $aGenetic variance
653 $aBreed of origin
653 $aGene network
653 $aGir × Holstein crossbred
700 1 $aGUIMARÃES, S. E. F.
700 1 $aVERARDO, L. L.
700 1 $aAZEVEDO, A. L. S.
700 1 $aVANDENPLAS, J.
700 1 $aSOARES, A. C. C.
700 1 $aSEVILLANO, C. A.
700 1 $aVERONEZE R
700 1 $aPIRES, M. de F. A.
700 1 $aFREITAS, C. de
700 1 $aPRATA, M. C. de A.
700 1 $aFURLONG, J.
700 1 $aVERNEQUE, R. da S.
700 1 $aMARTINS, M. F.
700 1 $aPANETTO, J. C. do C.
700 1 $aCARVALHO, W. A.
700 1 $aGOBO, D. O. R.
700 1 $aSILVA, M. V. G. B.
700 1 $aMACHADO, M. A.
773 $tJournal of Dairy Science$gv. 101, n. 12, p. 11020-11032, 2018.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 66 | |
| 42. |  | SILVA, G. da; CARPENTIERI-PIPOLO, V.; RIEDER, R.; PATRICIO, D. I.; VILARINHO, A. A. Uso de ferramenta de bioinformática para visualização de dados de pedigree na pesquisa e melhoramento de cevada. In: MOSTRA DE INICIAÇÃO CIENTÍFICA, 16.; MOSTRA DE PÓS-GRADUAÇÃO DA EMBRAPA TRIGO, 13., 2021, Passo Fundo. Anais... Passo Fundo: Embrapa Trigo, 2021.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Trigo. |
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| 44. | | LUDWIG, L. J.; CARPENTIERI-PIPOLO, V.; LOPES, K. B. A.; MINELLA, E.; BELEIA, A. D. P.; GROSSMANN, M. V. Comparison and quality evaluation of hull-less and covered Brazilian barleyfor food industry application. Revista Brasileira de Ciências Agrárias, v. 14, n. 4, e6942, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Trigo. |
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| 45. | | CARPENTIERI-PÍPOLO, V.; KIILH, T. A. M.; DIAS, W. P.; SOUZA, A. de; FELICI, P. H. N. Desenvolvimento de Heterodera glycines em cultivares resistentes e suscetível de soja. Semina: Ciências Agrárias, Londrina, v. 26, n. 4, p. 485-488, out./dez. 2005.| Biblioteca(s): Embrapa Soja. |
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| 46. | | CARPENTIERI-PÍPOLO, V.; PAGLIOSA, E. S.; ORO, T. H.; LOPES, K. B. de A.; ZUCCARELI, C.; GARBUGLIO, D. D. Repetibilidade na germinação pré-colheita em trigo. In: REUNIÃO DA COMISSÃO BRASILEIRA DE PESQUISA DE TRIGO E TRITICALE, 8.; SEMINÁRIO TÉCNICO DO TRIGO, 9., 2014, Canela; REUNIÃO DA COMISSÃO BRASILEIRA DE PESQUISA DE TRIGO E TRITICALE, 9.; SEMINÁRIO TÉCNICO DO TRIGO, 10., 2015, Passo Fundo. Anais... Passo Fundo: Biotrigo Genética: Embrapa Trigo, 2015. 2014 - Melhoramento, Aptidão industrial e Sementes - Trabalho 138. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Trigo. |
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| 47. | | CARPENTIERI-PÍPOLO, V.; SOUZA, A. de; ALMEIDA, L. A. de; KIIHL, R. A. de S.; PÍPOLO, A. E. Herança do hilo esparramado em sementes de soja. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 42, n. 1, p. 127-129, jan. 2007.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Soja; Embrapa Unidades Centrais. |
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| 48. | | CARPENTIERI-PÍPOLO, V.; SOUZA, A.; ALMEIDA, L. A. de; PÍPOLO, A. E.; KIIHL, R. A. de S. Herança de hilo esparramado em sementes de soja. In: CONGRESSO BRASILEIRO DE SOJA, 4., 2006, Londrina. Resumos... Londrina: Embrapa Soja, 2006. p. 130. Organizado por Odilon Ferreira Saraiva, Simone Ery Grosskopf.| Biblioteca(s): Embrapa Soja. |
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| 49. | | CARPENTIERI-PÍPOLO, V.; SOUZA, A.; ALMEIDA, L. A. de; PÍPOLO, A. E.; KIIHL, R. A. de S. Herança de hilo marrom em sementes pretas em soja (Glycine max (L.) Merrill). In: CONGRESSO BRASILEIRO DE SOJA, 4., 2006, Londrina. Resumos... Londrina: Embrapa Soja, 2006. p. 131. Organizado por Odilon Ferreira Saraiva, Simone Ery Grosskopf.| Biblioteca(s): Embrapa Soja. |
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| 51. | | CARPENTIERI-PIPOLO, V.; CASTRO, R. L. de; CAIERAO, E.; SCHEEREN, P. L.; SILVA, G.; ROSA, C. G. da. Avaliação de genótipos de trigo spelta (Triticum aestivum l. Subsp. Spelta (l.) Thell.) Para pré-melhoramento e produto alternativo para compor misturas de farinhas. In: REUNIÃO DA COMISSÃO BRASILEIRA DE PESQUISA DE TRIGO E TRITICALE, 15., 2022. Atas e resumos... Passo Fundo: Acervus, 2023. p. 269-273. Gilberto Rocca da Cunha, Eduardo Caierão, organizadores.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Trigo. |
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| 52. | | CARPENTIERI-PIPOLO, V.; CARRAO-PANIZZI; M. C.; MANDARINO, J. M. G.; DIAS, V. P.; BRUEL, D. C. Reacao de genotipos de soja, com alto teor isoflavonoides, a Meloidogyne javanica. In: CONGRESSO BRASILEIRO DE SOJA, 1999, Londrina. Anais... Londrina: Embrapa Soja, 1999. p.519. (Embrapa Soja. Documentos, 124).| Biblioteca(s): Embrapa Soja. |
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| 54. | | CARPENTIERI-PIPOLO, V.; HUNGRIA, M.; NOGUEIRA, M. A.; DEGRASSI, G.; LOPES, K. B. A.; ORO, T. H.; PAGLIOSA, E. S.; HOSHINO, R. T.; SCHNITZER, J. A. Caracterização fenotípica de bactérias endofíticas isoladas de cultivares de soja transgênica e convencional. In: REUNIÃO DE PESQUISA DE SOJA, 34., 2014, Londrina. Resumos expandidos... Londrina: Embrapa Soja, 2014. p. 184-186.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Soja; Embrapa Trigo. |
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| 55. | | CARPENTIERI-PIPOLO, V.; CONSOLI, L.; SCHEEREN, P. L.; CASTRO, R. L. de; KIIHL, T. A. M.; SILVA, G.; ROSA, C. G. da. Disponibilização digital de imagens e dados de características da coleção ativa de trigo da Embrapa Trigo no Portal Alelo Recursos Genéticos. In: REUNIÃO DA COMISSÃO BRASILEIRA DE PESQUISA DE TRIGO E TRITICALE, 15., 2022. Atas e resumos... Passo Fundo: Acervus, 2023. p. 264-268. Gilberto Rocca da Cunha, Eduardo Caierão, organizadores.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Trigo. |
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| 56. | | LOPES, K. B. de A.; CARPENTIERI-PIPOLO, V.; FIRA, D.; BALATTI, P. A.; LOPEZ, S. M. Y.; ORO, T. H.; PAGLIOSA, E. S.; DEGRASSI, G. Screening of bacterial endophytes as potential biocontrol agents against soybean diseases. Journal of Applied Microbiology, v. 125, n. 5, p. 1466-1481, Nov. 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Trigo. |
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| 57. | | SOUZA, S. G. H. de; SANTOS, T. B. dos; DOMINGUES, D. S.; BERNADAC, A.; BOUZAYEN, M.; PEREIRA, L. F. P.; DEGRASSI, G.; CARPENTIERI-PIPOLO, V. Identification, structure analyses and expression pattern of the ERF transcription factor family in coffea arabica. Journal of Botanical Research, v. 3, n.1, Jan. 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: C - 0 |
| Biblioteca(s): Embrapa Café; Embrapa Trigo. |
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| 58. | | CARPENTIERI-PIPOLO, V.; DESTRO, D.; PRETE, C. E. C.; GONZALES, M. G. N.; POPPER, I.; ZANATTA, S.; SILVA, F. A. M. da. Seleção de genótipos parentais de acerola com base na divergência genética multivariada. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 35, n. 8, p. 1613-19, ago. 2000. Título em inglês: West Indian Cherry parental genotype selection based on multivariate genetic divergence.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 59. | | SILVA, D. A.; BARRETO, T. P.; CARPENTIERI-PIPOLO, V.; MANDARINO, J. M. G.; MARIN, S. R. R.; CARRÃO-PANIZZI, M. C.; ABDELNOOR, R. V. Validação de marcadores moleculares para uso na seleção assistida em soja para ausência das enzimas lipoxigenase e do inibidor de tripsina Kunitz. In: CONGRESSO BRASILEIRO DE SOJA, 5.; MERCOSOJA 2009, Goiânia. Resumos... Londrina: Embrapa Soja, 2009. p. 106, trab. 180. Editado por Adilson de Oliveira Júnior, Odilon Ferreira Saraiva, Clara Beatriz Hoffmann Campo, César de Castro.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Soja. |
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| 60. | | CACAO, S. M. B.; SILVA, N. V.; DOMINGUES, D. S.; VIEIRA, L. G. E.; DINIZ, L. E. C.; VINECKY, F.; ALVES, G. S. C.; ANDRADE, A. C.; CARPENTIERI PIPOLO, V.; PEREIRA, L. F. P. Construction and characterization of a BAC library from the Coffea arabica genotype Timor Hybrid CIFC 832/2. Genetica, v. 141, n. 1-3, p. 217-226, 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| Registros recuperados : 66 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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