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Registro Completo |
Biblioteca(s): |
Ebooks. |
Data corrente: |
01/02/2013 |
Data da última atualização: |
04/02/2013 |
Autoria: |
FERGUSON-SMITH, A. C.; GREALLY, J. M.; MARTIENSSEN, R. A. |
Afiliação: |
Anne C. Ferguson-smith; John M. Greally; Robert A. Martienssen. |
Título: |
Epigenomics. |
Ano de publicação: |
2009 |
Fonte/Imprenta: |
Springer eBooks. |
Descrição Física: |
digital. |
ISBN: |
9781402091872 |
DOI: |
10.1007/978-1-4020-9187-2 |
Idioma: |
Inglês |
Conteúdo: |
Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times. The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease. The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum. MenosEpigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times. The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease. The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biolog... Mostrar Tudo |
Palavras-Chave: |
Biomedicine; Biomedicine general. |
Thesaurus Nal: |
medicine. |
Categoria do assunto: |
-- |
URL: |
https://dx.doi.org/10.1007/978-1-4020-9187-2
|
Marc: |
LEADER 02356nam a2200205 a 4500 001 1947323 005 2013-02-04 008 2009 bl uuuu u0uu1 u #d 020 $a9781402091872 024 7 $a10.1007/978-1-4020-9187-2$2DOI 100 1 $aFERGUSON-SMITH, A. C. 245 $aEpigenomics.$h[electronic resource] 260 $aSpringer eBooks.$c2009 300 $cdigital. 520 $a<P>Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times.</P> <P>The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease.</P> <P>The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum.</P> 650 $amedicine 653 $aBiomedicine 653 $aBiomedicine general 700 1 $aGREALLY, J. M. 700 1 $aMARTIENSSEN, R. A.
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1. | | CRUZ, J. L.; SOUZA, L. S.; PELACANI, C. R. Avaliacao preliminar de genotipos de mandioca para tolerancia ao deficit hidrico Sao Pedro, SP: Centro de Raizes Tropicais/UNESP/SBM, 1996. 1p. In: CONGRESSO LATINO AMERICANO DE RAIZES TROPICAIS, 1, E CONGRESSO BRASILEIRO DE MANDIOCA, 9, 1996, Sao Pedro, SP. Programa e Resumos...Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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16. | | BORGES, A. L.; SOUZA, L. S.; NASCIMENTO, C. A. C. do; SANTOS, J. de S. Boro na produção do maracujazeiro em solo de tabuleiro costeiro. In: REUNIÃO BRASILEIRA DE FERTILIDADE DO SOLO E NUTRIÇÃO DE PLANTAS, 29.; REUNIÃO BRASILEIRA SOBRE MICORRIZAS, 13.; SIMPÓSIO BRASILEIRO DE MICROBIOLOGIA DO SOLO, 11.; REUNIÃO BRASILEIRA DE BIOLOGIA DO SOLO, 8., 2010, Guarapari. Fontes de nutrientes e produção agrícola: modelando o futuro: anais. Viçosa, MG: Sociedade Brasileira de Ciência do Solo, 2010. 1 CD-ROM. pdf 0265Tipo: Artigo em Anais de Congresso |
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20. | | AUAD, A. M.; OLIVEIRA, S. A.; SOUZA, L. S.; FERREIRA, R. B. Duração e sobrevivência de Chrysoperla externa (Hagen, 1861) alimentados com Rhopalosiphum padi (Linneaus, 1758) submetidos a diferentes temperaturas. In: CONGRESSO LATINO AMERICANO DE ECOLOGIA, 3., 2009, São Lourenço. Anais... São Lourenço: CEB, 2009.Tipo: Artigo em Anais de Congresso / Nota Técnica |
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