Data/hora: 14/06/2024 10:23:04

Biblioteca(s): 	Embrapa Amazônia Ocidental.	
Data corrente: 	16/10/2023	
Data da última atualização: 	16/10/2023	
Autoria: 	CHURA, S. S. D.; MEMÓRIA, K. A. S.; LOPES, A. T.; PELISSARI, F. M.; SILVEIRA, J. V. W. da; BEZERRA, J. de A.; CHAVES, F. C. M.; RODRIGUES, A. P.; FARIA, J. A. Q. A.; CARNEIRO, G.	
Afiliação: 	SOFIA SANTOS DONAIRE CHURA, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; KATHELEN ANNE SUDO MEMÓRIA, UNIVERSIDADE FEDERAL DO AMAZONAS; AMANDA TIBÃES LOPES, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; FRANCIELE MARIA PELISSARI, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JOÃO VINÍCIOS WIRBITZKI DA SILVEIRA, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JAQUELINE DE ARAÚJO BEZERRA, FEDERAL INSTITUTE OF EDUCATION, SCIENCE AND TECHNOLOGY OF AMAZONAS; FRANCISCO CELIO MAIA CHAVES, CPAA; ANA PAULA RODRIGUES, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS; JERUSA ARAÚJO QUINTÃO ARANTES FARIA, UNIVERSIDADE FEDERAL DO AMAZONAS; GUILHERME CARNEIRO, FEDERAL UNIVERSITY OF JEQUITINHONHA AND MUCURI VALLEYS.	
Título: 	Red sacaca essential oil-loaded nanostructured lipid carriers optimized by factorial design: cytotoxicity and cellular reactive oxygen species levels.	
Ano de publicação: 	2023	
Fonte/Imprenta: 	Frontiers in Pharmacology, v. 14, art. 1176629, 2023.	
DOI: 	https://doi.org/10.3389/fphar.2023.1176629	
Idioma: 	Inglês	
Conteúdo: 	Amazonian flora includes several species with the potential to develop pharmaceutical and biotechnological products. The essential oils from Amazonian species possess some biological properties, such as antioxidant, antibacterial, and cytotoxic activities. The essential oil of red sacaca (RSO), Croton cajucara Benth., contains metabolites characterized by antioxidant and anti-inflammatory activities. Nanostructured lipid carriers (NLC) are an advantageous alternative for the effective delivery of drugs because they can solubilize lipophilic actives and reduce their cytotoxicity. This study aimed to optimize the synthesis of RSO-loaded nanostructured lipid carriers (NLC-RSO) using a 23 factorial design and investigate their antioxidant and cytotoxic effects. The red sacaca essential oil (RSO) metabolite profile was characterized using gas chromatography coupled with a mass spectrometer (GC-MS), identifying 33 metabolites, with linalool and 7-hydroxy-calamenene as the major ones, as reported in the literature.	
Palavras-Chave: 	Amazon plants; Nanotecnologia; Plant metabolites; Rotational central composite design; Sacaca.	
Thesaurus Nal: 	Croton cajucara; Nanotechnology.	
Categoria do assunto: 	--	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1157230/1/fphar-14-1176629.pdf	
Registro original: 	Embrapa Amazônia Ocidental (CPAA)	
Exemplares: 	CPAA - (39018-1) - UPC - AP - DD -  -  -  - DIS