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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Corte. |
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Data corrente: |
04/11/2014 |
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Data da última atualização: |
20/02/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SOMAVILLA, A. L.; HIGA, R. H.; ROSA, A. do N.; SIQUEIRA, F.; SILVA, L. O. C. da; TORRES JUNIOR, R. A. de A.; MUDADU, M. de A.; ALENCAR, M. M. de; REGITANO, L. C. de A. |
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Afiliação: |
UNESP/FCAV, Jaboticabal, Brasil.; ROBERTO HIROSHI HIGA, CNPTIA; ANTONIO DO NASCIMENTO ROSA, CNPGC; FABIANE SIQUEIRA, CNPGC; LUIZ OTAVIO CAMPOS DA SILVA, CNPGC; ROBERTO AUGUSTO DE A TORRES JUNIOR, CNPGC; MAURICIO DE ALVARENGA MUDADU, CPPSE; MAURICIO MELLO DE ALENCAR, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
A genome-wide scan for selection signatures in Nellore cattle. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Animal Genetics, v. 45, n. 6, p. 771-781, 2014. |
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DOI: |
10.1111/age.12210 |
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Idioma: |
Inglês |
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Conteúdo: |
Brazilian Nellore cattle (Bos indicus) have been selected for growth traits for over more than four decades. In recent years, reproductive and meat quality traits have become more important because of increasing consumption, exports and consumer demand. The identification of genome regions altered by artificial selection can potentially permit a better understanding of the biology of specific phenotypes that are useful for the development of tools designed to increase selection efficiency. Therefore, the aims of this study were to detect evidence of recent selection signatures in Nellore cattle using extended haplotype homozygosity methodology and BovineHD marker genotypes (>777 000 single nucleotide polymorphisms) as well as to identify corresponding genes underlying these signals. Thirty-one significant regions (P < 0.0001) of possible recent selection signatures were detected, and 19 of these overlapped quantitative trait loci related to reproductive traits, growth, feed efficiency, meat quality, fatty acid profiles and immunity. In addition, 545 genes were identified in regions harboring selection signatures. Within this group, 58 genes were associated with growth, muscle and adipose tissue metabolism, reproductive traits or the immune system. Using relative extended haplotype homozygosity to analyze high-density single nucleotide polymorphism marker data allowed for the identification of regions potentially under artificial selection pressure in the Nellore genome, which might be used to better understand autozygosity and the effects of selection on the Nellore genome. MenosBrazilian Nellore cattle (Bos indicus) have been selected for growth traits for over more than four decades. In recent years, reproductive and meat quality traits have become more important because of increasing consumption, exports and consumer demand. The identification of genome regions altered by artificial selection can potentially permit a better understanding of the biology of specific phenotypes that are useful for the development of tools designed to increase selection efficiency. Therefore, the aims of this study were to detect evidence of recent selection signatures in Nellore cattle using extended haplotype homozygosity methodology and BovineHD marker genotypes (>777 000 single nucleotide polymorphisms) as well as to identify corresponding genes underlying these signals. Thirty-one significant regions (P < 0.0001) of possible recent selection signatures were detected, and 19 of these overlapped quantitative trait loci related to reproductive traits, growth, feed efficiency, meat quality, fatty acid profiles and immunity. In addition, 545 genes were identified in regions harboring selection signatures. Within this group, 58 genes were associated with growth, muscle and adipose tissue metabolism, reproductive traits or the immune system. Using relative extended haplotype homozygosity to analyze high-density single nucleotide polymorphism marker data allowed for the identification of regions potentially under artificial selection pressure in the Nellore genome, whic... Mostrar Tudo |
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Palavras-Chave: |
Relative extended haplotype homozygosity; Single nucleotide polymorphisms. |
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Thesaurus Nal: |
Beef cattle; Genotyping; Linkage disequilibrium; Zebu. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02493naa a2200301 a 4500
001 1999171
005 2018-02-20
008 2014 bl uuuu u00u1 u #d
024 7 $a10.1111/age.12210$2DOI
100 1 $aSOMAVILLA, A. L.
245 $aA genome-wide scan for selection signatures in Nellore cattle.$h[electronic resource]
260 $c2014
520 $aBrazilian Nellore cattle (Bos indicus) have been selected for growth traits for over more than four decades. In recent years, reproductive and meat quality traits have become more important because of increasing consumption, exports and consumer demand. The identification of genome regions altered by artificial selection can potentially permit a better understanding of the biology of specific phenotypes that are useful for the development of tools designed to increase selection efficiency. Therefore, the aims of this study were to detect evidence of recent selection signatures in Nellore cattle using extended haplotype homozygosity methodology and BovineHD marker genotypes (>777 000 single nucleotide polymorphisms) as well as to identify corresponding genes underlying these signals. Thirty-one significant regions (P < 0.0001) of possible recent selection signatures were detected, and 19 of these overlapped quantitative trait loci related to reproductive traits, growth, feed efficiency, meat quality, fatty acid profiles and immunity. In addition, 545 genes were identified in regions harboring selection signatures. Within this group, 58 genes were associated with growth, muscle and adipose tissue metabolism, reproductive traits or the immune system. Using relative extended haplotype homozygosity to analyze high-density single nucleotide polymorphism marker data allowed for the identification of regions potentially under artificial selection pressure in the Nellore genome, which might be used to better understand autozygosity and the effects of selection on the Nellore genome.
650 $aBeef cattle
650 $aGenotyping
650 $aLinkage disequilibrium
650 $aZebu
653 $aRelative extended haplotype homozygosity
653 $aSingle nucleotide polymorphisms
700 1 $aHIGA, R. H.
700 1 $aROSA, A. do N.
700 1 $aSIQUEIRA, F.
700 1 $aSILVA, L. O. C. da
700 1 $aTORRES JUNIOR, R. A. de A.
700 1 $aMUDADU, M. de A.
700 1 $aALENCAR, M. M. de
700 1 $aREGITANO, L. C. de A.
773 $tAnimal Genetics$gv. 45, n. 6, p. 771-781, 2014.
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| 13. |  | ROSA, A. do N.; SILVA, L. O. C. da; NOBRE, P. R. C. Avaliação genética, zootécnica e funcional de touros. In: CURSO DE ANDROLOGIA EM BOVINOS, 2., 2006, Campo Grande, MS. [Compilação dos trabalhos apresentados]. Campo Grande, MS: Embrapa Gado de Corte, 2006. p.154-171. CNPGC.| Biblioteca(s): Embrapa Gado de Corte. |
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