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Registro Completo |
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
26/09/2018 |
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Data da última atualização: |
06/01/2020 |
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Tipo da produção científica: |
Comunicado Técnico/Recomendações Técnicas |
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Autoria: |
ABREU, U. G. P. de; ROSA, A. do N.; PORTES, J. V.; NOGUEIRA, E.; SILVA, J. C. B.; OLIVEIRA, L. O. F. de; SILVA, L. O. C. da; BATISTA, D. S. do N. |
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Afiliação: |
URBANO GOMES PINTO DE ABREU, CPAP; ANTONIO DO NASCIMENTO FERREIRA ROSA, CNPGC; JULIANA VARCHAKI PORTES, UFRGS; ERIKLIS NOGUEIRA, CPAP; JULIANA CORREA BORGES SILVA, CPAP; LUIZ ORCIRIO FIALHO DE OLIVEIRA, CNPGC; LUIZ OTAVIO CAMPOS DA SILVA, CNPGC; DAYANNA SCHIAVI DO NASC BATISTA, CNPGC. |
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Título: |
Touros Nelore Pantaneiros com DEP's: potencial impacto econômico para o sistema de produção. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Corumbá: Embrapa Pantanal, 2019. |
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Páginas: |
9 p. |
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Série: |
(Embrapa Pantanal. Comunicado Técnico, 110) |
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Idioma: |
Português |
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Conteúdo: |
Como fornecedores de genética, os produtores de touros têm sido desafiados a acompanhar o ritmo de novas tecnologias para acompanhar o desempenho de seus animais e ajudar seus clientes a interpretar os sistemas de avaliação em constante mudança. Pois a genealogia, o genótipo, a informação fenotípica e o desempenho da progênie são incorporados ao cálculo ao mesmo tempo. |
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Palavras-Chave: |
Valores genéticos. |
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Thesagro: |
Gado Nelore; Melhoramento Genético Animal; Parâmetro Genético. |
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Thesaurus Nal: |
Animal genetic resources; Beef cattle. |
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Categoria do assunto: |
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/207478/1/Touros-Nelore-Pantaneiros-2019.pdf
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Marc: |
LEADER 01270nam a2200289 a 4500
001 2096368
005 2020-01-06
008 2019 bl uuuu u0uu1 u #d
100 1 $aABREU, U. G. P. de
245 $aTouros Nelore Pantaneiros com DEP's$bpotencial impacto econômico para o sistema de produção.$h[electronic resource]
260 $aCorumbá: Embrapa Pantanal$c2019
300 $a9 p.
490 $a(Embrapa Pantanal. Comunicado Técnico, 110)
520 $aComo fornecedores de genética, os produtores de touros têm sido desafiados a acompanhar o ritmo de novas tecnologias para acompanhar o desempenho de seus animais e ajudar seus clientes a interpretar os sistemas de avaliação em constante mudança. Pois a genealogia, o genótipo, a informação fenotípica e o desempenho da progênie são incorporados ao cálculo ao mesmo tempo.
650 $aAnimal genetic resources
650 $aBeef cattle
650 $aGado Nelore
650 $aMelhoramento Genético Animal
650 $aParâmetro Genético
653 $aValores genéticos
700 1 $aROSA, A. do N.
700 1 $aPORTES, J. V.
700 1 $aNOGUEIRA, E.
700 1 $aSILVA, J. C. B.
700 1 $aOLIVEIRA, L. O. F. de
700 1 $aSILVA, L. O. C. da
700 1 $aBATISTA, D. S. do N.
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Registro original: |
Embrapa Pantanal (CPAP) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
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Data corrente: |
25/03/2024 |
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Data da última atualização: |
25/03/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 4 |
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Autoria: |
CARVALHO, W. A.; GASPAR, E. B.; DOMINGUES, R.; REGITANO, L. C. de A.; CARDOSO, F. F. |
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Afiliação: |
WANESSA ARAUJO CARVALHO, CNPGL; EMANUELLE BALDO GASPAR, CNPGL; ROBERT DOMINGUES, CNPGL; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL. |
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Título: |
Genetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle: a systems biology perspective. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Mammalian Genome, 2024. |
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DOI: |
https://doi.org/10.1007/s00335-024-10030-x |
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Idioma: |
Inglês |
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Notas: |
First online. |
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Conteúdo: |
Approximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle. MenosApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates ... Mostrar Tudo |
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Thesagro: |
Bovino; Carrapato; Doença Animal; Parasitismo; Resistência. |
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Thesaurus NAL: |
Amber disease; Parasitism; Ticks. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02431naa a2200289 a 4500
001 2163111
005 2024-03-25
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00335-024-10030-x$2DOI
100 1 $aCARVALHO, W. A.
245 $aGenetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle$ba systems biology perspective.$h[electronic resource]
260 $c2024
500 $aFirst online.
520 $aApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle.
650 $aAmber disease
650 $aParasitism
650 $aTicks
650 $aBovino
650 $aCarrapato
650 $aDoença Animal
650 $aParasitismo
650 $aResistência
700 1 $aGASPAR, E. B.
700 1 $aDOMINGUES, R.
700 1 $aREGITANO, L. C. de A.
700 1 $aCARDOSO, F. F.
773 $tMammalian Genome, 2024.
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Embrapa Gado de Leite (CNPGL) |
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