Data/hora: 15/06/2024 02:45:58

Biblioteca(s): 	Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios.	
Data corrente: 	02/01/2023	
Data da última atualização: 	29/02/2024	
Autoria: 	LIMA, L. F. DE; ANDRADE-PINHEIRO, J. C.; FREITAS, M. A.; SILVA, A. I. DA; FONSECA, V. J. A.; SILVA, T. G. DA; SILVA, J. C. P. DA; LIMA, R. H. DE; SALES, D. L.; NEVES, R. P.; BRITO, E. S. de; RIBEIRO, P. R. V.; CANUTO, K. M.; COUTINHO, H. D. M.; SIYADATPANAH, A.; KIM, B.; MORAIS-BRAGA, M. F. B.	
Afiliação: 	LUCIENE FERREIRA DE LIMA, University Regional of Cariri; JACQUELINE COSMO ANDRADE-PINHEIRO, University Regional of Cariri; MARIA AUDILENE FREITAS, University Federal of Pernambuco; ADRIELY IDALINA DA SILVA, University Federal of Pernambuco; VICTOR JUNO ALENCAR FONSECA, University Regional of Cariri; TAÍS GUSMÃO DA SILVA, University Regional of Cariri; JOSEFA CAROLAINE PEREIRA DA SILVA, University Regional of Cariri; ROSILAINE HONORATO DE LIMA, University Regional of Cariri; DÉBORA LIMA SALES, University Regional of Cariri; REJANE PEREIRA NEVES, University Federal of Pernambuco; EDY SOUSA DE BRITO, CNAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; HENRIQUE DOUGLAS MELO COUTINHO, University Regional of Cariri; ABOLGHASEM SIYADATPANAH, Birjand University of Medical Sciences; BONGLEE KIM, Kyung Hee University; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, University Regional of Cariri.	
Título: 	Anti-Candida properties of Gossypium hirsutum L.: enhancement of fungal growth, biofilm production and antifungal resistance.	
Ano de publicação: 	2022	
Fonte/Imprenta: 	Pharmaceutics, v. 14, n. 698, 2022.	
Páginas: 	18 p.	
DOI: 	https://doi.org/10.3390/pharmaceutics140406982022	
Idioma: 	Inglês	
Conteúdo: 	(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that may be potentially linked to the combined activity of chemical constituents identified in its extracts.	
Palavras-Chave: 	Antimicrobial resistance; Biofilm eradication; Erradicação do biofilme; Resistência antimicrobiana; UPLC-QTOF-MS/MS.	
Thesagro: 	Gossypium Hirsutum; Malvaceae.	
Categoria do assunto: 	--
W Química e Física	
Registro original: 	Embrapa Alimentos e Territórios (CNAT)	
Exemplares: 	CNPAT - (17034-1) - UPC - AP - DD -  -  -  - DIS
CNAT - (12-1) - UPC - AP - DD -  -  -  - DIS