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Registro Completo |
Biblioteca(s): |
Embrapa Tabuleiros Costeiros. |
Data corrente: |
21/12/2022 |
Data da última atualização: |
21/12/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
SENA FILHO, J. G. de; ALMEIDA, A. S. de; PINTO ZEVALLOS, D.; BARRETO, I. C.; CAVALCANTI, S. C. de H.; NUNES, R.; TEODORO, A. V.; XAVIER, H. S.; BARBOSA FILHO, J. M.; GUAN, L.; NEVES, A. L. A.; DURINGER, J. M. |
Afiliação: |
JOSE GUEDES DE SENA FILHO, CPATC; ANDERSON SOARES DE ALMEIDA, UFS; DELIA PINTO ZEVALLOS; IGHOR COSTA BARRETO; SOCRATES CABRAL DE HOLANDA CAVALCANTI; ROGERIA NUNES; ADENIR VIEIRA TEODORO, CPATC; HAROUDO SATIRO XAVIER; JOSE MARIA BARBOSA FILHO; LELUO GUAN; ANDRE L. A. NEVES; JENNIFER M. DURINGER. |
Título: |
From plant scent defense to biopesticide discovery: evaluation of toxicity and acetylcholinesterase docking properties for Lamiaceae monoterpenes. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Crop Protection, v. 164, 106126, 2023. |
Idioma: |
Inglês |
Conteúdo: |
Monoterpenes are a highly diverse group of chemical scents that originate from plant secondary metabolic processes, one purpose of which is to serve as a defense against herbivores. Plant-derived monoterpenes pro- duced from Lamiaceae species have demonstrated acaricidal activity against pest mites and ticks. However, the mechanism by which these compounds carry out the demise of this group of arachnids is poorly understood. Here, we review the chemistry and bioactivity of these promising compounds and subsequently assess their potential toxicity to mites and ticks through measurement of their docking ability to amino acid residues of the binding pocket of Drosophila melanogaster acetylcholinesterase (AChE). We identified 27 monoterpenes of the Lamiaceae family from the literature that were effective against mite (Varroidae, Tetranychidae, Eriophyidae) and tick (Ixodidae) species that are problematic in agricultural production. Screening of these compounds showed that monoterpenoids possessing methyl groups, such as carvacrol, linalool, ?-terpineol, bornyl acetate, and terpine-4-ol, strongly bind to D. melanogaster AChE. Linalool, which fits into the binding pocket in the amino acid catalytic triad of AChE (oxyanion hole residues, hydrogen bond interaction with GLU 237, and anionic binding with TRP 83), was identified as the most promising target for further optimization studies. We propose that monoterpenes which interact strongly with amino acid residues of the AChE receptor be targeted for development of effective, naturally produced biocontrol pesticides, as this model demonstrates potential for discovery of new acaricide compounds in a high throughput manner MenosMonoterpenes are a highly diverse group of chemical scents that originate from plant secondary metabolic processes, one purpose of which is to serve as a defense against herbivores. Plant-derived monoterpenes pro- duced from Lamiaceae species have demonstrated acaricidal activity against pest mites and ticks. However, the mechanism by which these compounds carry out the demise of this group of arachnids is poorly understood. Here, we review the chemistry and bioactivity of these promising compounds and subsequently assess their potential toxicity to mites and ticks through measurement of their docking ability to amino acid residues of the binding pocket of Drosophila melanogaster acetylcholinesterase (AChE). We identified 27 monoterpenes of the Lamiaceae family from the literature that were effective against mite (Varroidae, Tetranychidae, Eriophyidae) and tick (Ixodidae) species that are problematic in agricultural production. Screening of these compounds showed that monoterpenoids possessing methyl groups, such as carvacrol, linalool, ?-terpineol, bornyl acetate, and terpine-4-ol, strongly bind to D. melanogaster AChE. Linalool, which fits into the binding pocket in the amino acid catalytic triad of AChE (oxyanion hole residues, hydrogen bond interaction with GLU 237, and anionic binding with TRP 83), was identified as the most promising target for further optimization studies. We propose that monoterpenes which interact strongly with amino acid residues of the AChE recept... Mostrar Tudo |
Palavras-Chave: |
Ácaros; Biopesticida. |
Thesagro: |
Aroma; Óleo Essencial; Pesticida. |
Thesaurus Nal: |
Essential oils. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1150182/1/From-plant-scent-defense-to-biopeseicide....pdf
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Marc: |
LEADER 02646naa a2200325 a 4500 001 2150182 005 2022-12-21 008 2023 bl uuuu u00u1 u #d 100 1 $aSENA FILHO, J. G. de 245 $aFrom plant scent defense to biopesticide discovery$bevaluation of toxicity and acetylcholinesterase docking properties for Lamiaceae monoterpenes.$h[electronic resource] 260 $c2023 520 $aMonoterpenes are a highly diverse group of chemical scents that originate from plant secondary metabolic processes, one purpose of which is to serve as a defense against herbivores. Plant-derived monoterpenes pro- duced from Lamiaceae species have demonstrated acaricidal activity against pest mites and ticks. However, the mechanism by which these compounds carry out the demise of this group of arachnids is poorly understood. Here, we review the chemistry and bioactivity of these promising compounds and subsequently assess their potential toxicity to mites and ticks through measurement of their docking ability to amino acid residues of the binding pocket of Drosophila melanogaster acetylcholinesterase (AChE). We identified 27 monoterpenes of the Lamiaceae family from the literature that were effective against mite (Varroidae, Tetranychidae, Eriophyidae) and tick (Ixodidae) species that are problematic in agricultural production. Screening of these compounds showed that monoterpenoids possessing methyl groups, such as carvacrol, linalool, ?-terpineol, bornyl acetate, and terpine-4-ol, strongly bind to D. melanogaster AChE. Linalool, which fits into the binding pocket in the amino acid catalytic triad of AChE (oxyanion hole residues, hydrogen bond interaction with GLU 237, and anionic binding with TRP 83), was identified as the most promising target for further optimization studies. We propose that monoterpenes which interact strongly with amino acid residues of the AChE receptor be targeted for development of effective, naturally produced biocontrol pesticides, as this model demonstrates potential for discovery of new acaricide compounds in a high throughput manner 650 $aEssential oils 650 $aAroma 650 $aÓleo Essencial 650 $aPesticida 653 $aÁcaros 653 $aBiopesticida 700 1 $aALMEIDA, A. S. de 700 1 $aPINTO ZEVALLOS, D. 700 1 $aBARRETO, I. C. 700 1 $aCAVALCANTI, S. C. de H. 700 1 $aNUNES, R. 700 1 $aTEODORO, A. V. 700 1 $aXAVIER, H. S. 700 1 $aBARBOSA FILHO, J. M. 700 1 $aGUAN, L. 700 1 $aNEVES, A. L. A. 700 1 $aDURINGER, J. M. 773 $tCrop Protection$gv. 164, 106126, 2023.
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Embrapa Tabuleiros Costeiros (CPATC) |
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Registro Completo
Biblioteca(s): |
Embrapa Tabuleiros Costeiros. |
Data corrente: |
18/11/2008 |
Data da última atualização: |
12/02/2009 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
ANDRADE, K. R.; CARVALHO, L. M. de; CARVALHO, H. W. L. de; OLIVEIRA, I. R. de; ALMEIDA, N. A. |
Afiliação: |
Kairon Rocha Andrade, (estagiário) Embrapa Tabuleiros Costeiros; Luciana Marques de Carvalho, Embrapa Tabuleiros Costeiros; Hélio Wilson Lemos de Carvalho, Embrapa Tabuleiros Costeiros; Ivênio Rubens de Oliveira, Embrapa Tabuleiros Costeiros; Nataly Ávila Almeida, (estagiária) Embrapa Tabuleiros Costeiros. |
Título: |
Desempenho de variedades de aipim em Umbaúba, estado de Sergipe. |
Ano de publicação: |
2008 |
Fonte/Imprenta: |
In: ENCONTRO DE INICIAÇÃO CIENTÍFICA, 18; ENCONTRO DE PÓS-GRADUAÇÃO, 4., 2008, São Cristóvão. Anais... São Cristóvão: UFS, 2008. Ciências agrárias. 1 CD-ROM. |
Idioma: |
Português |
Palavras-Chave: |
Aipim; Resumo. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00628naa a2200181 a 4500 001 1372654 005 2009-02-12 008 2008 bl uuuu u00u1 u #d 100 1 $aANDRADE, K. R. 245 $aDesempenho de variedades de aipim em Umbaúba, estado de Sergipe. 260 $c2008 653 $aAipim 653 $aResumo 700 1 $aCARVALHO, L. M. de 700 1 $aCARVALHO, H. W. L. de 700 1 $aOLIVEIRA, I. R. de 700 1 $aALMEIDA, N. A. 773 $tIn: ENCONTRO DE INICIAÇÃO CIENTÍFICA, 18; ENCONTRO DE PÓS-GRADUAÇÃO, 4., 2008, São Cristóvão. Anais... São Cristóvão: UFS, 2008. Ciências agrárias. 1 CD-ROM.
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