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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Instrumentação. |
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Data corrente: |
28/09/2018 |
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Data da última atualização: |
15/01/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SCHNEIDER, R.; MERCANTE, L. A.; ANDRE, R. S.; BRANDÃO, H. M.; MATTOSO, L. H. C.; CORREA, D. S. |
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Afiliação: |
LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA; DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Biocompatible electrospun nanofibers containing cloxacillin: Antibacterial activity and effect of PH on the release profile. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Reactive and Functional Polymers, n. 132, p. 26-35, nov. 2018. |
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ISSN: |
1381-5148 |
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DOI: |
10.1016/j.reactfunctpolym.2018.09.001 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract The effectiveness of antibiotics toward resistant strains of bacteria has brought serious concerns related to human and animal health. Controlled drug release systems, especially those based on polymer and polymer-based nanostructures appears as a remarkable approach, once they can potentially improve the therapeutic outcomes toward bacterial infections, while requiring lower amounts of drugs. The current study was designed to investigate the incorporation and release profile of a drug loaded in biodegradable electrospun nanofibrous membranes, based on the drug-polymer interactions, as well as its ability to inhibit bacterial growth. For that purpose, nanofibrous membranes of Ecovio® (EC), a polymer blend composed by poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT), loaded with different cloxacillin (CLOX) contents were successfully produced via electrospinning technique. Electrospun nanofibers of EC unloaded and loaded with drug presented smooth surface with a mean diameter close to 600 nm. The physical-chemical characterizations by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the successful drug encapsulation achieved by electrospinning technique. In vitro studies revealed that the developed drug-loaded nanofibrous membrane was successful in inhibiting S. aureus growth. The cumulative release of drug from EC nanofibrous membranes containing 20% of CLOX was demonstrated to be pH dependent, where the antibiotic release rate was much faster for pH 7.3 than that for pH 5.5. In this way, the mechanism involved in the release could be either Fickian or non-Fickian depending on the pH environment. The simple and efficient strategy presented here to develop antimicrobial nanofibrous membrane make them promising for drug delivery carrier and wound dressing applications. MenosAbstract The effectiveness of antibiotics toward resistant strains of bacteria has brought serious concerns related to human and animal health. Controlled drug release systems, especially those based on polymer and polymer-based nanostructures appears as a remarkable approach, once they can potentially improve the therapeutic outcomes toward bacterial infections, while requiring lower amounts of drugs. The current study was designed to investigate the incorporation and release profile of a drug loaded in biodegradable electrospun nanofibrous membranes, based on the drug-polymer interactions, as well as its ability to inhibit bacterial growth. For that purpose, nanofibrous membranes of Ecovio® (EC), a polymer blend composed by poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT), loaded with different cloxacillin (CLOX) contents were successfully produced via electrospinning technique. Electrospun nanofibers of EC unloaded and loaded with drug presented smooth surface with a mean diameter close to 600 nm. The physical-chemical characterizations by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the successful drug encapsulation achieved by electrospinning technique. In vitro studies revealed that the developed drug-loaded nanofibrous membrane was successful in inhibiting S. aureus growth. The cumulative release of drug from EC nanofibrous membranes containing 20% o... Mostrar Tudo |
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Palavras-Chave: |
Drug delivery; Electrospinning; Modulated release. |
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Categoria do assunto: |
--
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02706naa a2200241 a 4500
001 2096544
005 2019-01-15
008 2018 bl uuuu u00u1 u #d
022 $a1381-5148
024 7 $a10.1016/j.reactfunctpolym.2018.09.001$2DOI
100 1 $aSCHNEIDER, R.
245 $aBiocompatible electrospun nanofibers containing cloxacillin$bAntibacterial activity and effect of PH on the release profile.$h[electronic resource]
260 $c2018
520 $aAbstract The effectiveness of antibiotics toward resistant strains of bacteria has brought serious concerns related to human and animal health. Controlled drug release systems, especially those based on polymer and polymer-based nanostructures appears as a remarkable approach, once they can potentially improve the therapeutic outcomes toward bacterial infections, while requiring lower amounts of drugs. The current study was designed to investigate the incorporation and release profile of a drug loaded in biodegradable electrospun nanofibrous membranes, based on the drug-polymer interactions, as well as its ability to inhibit bacterial growth. For that purpose, nanofibrous membranes of Ecovio® (EC), a polymer blend composed by poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT), loaded with different cloxacillin (CLOX) contents were successfully produced via electrospinning technique. Electrospun nanofibers of EC unloaded and loaded with drug presented smooth surface with a mean diameter close to 600 nm. The physical-chemical characterizations by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the successful drug encapsulation achieved by electrospinning technique. In vitro studies revealed that the developed drug-loaded nanofibrous membrane was successful in inhibiting S. aureus growth. The cumulative release of drug from EC nanofibrous membranes containing 20% of CLOX was demonstrated to be pH dependent, where the antibiotic release rate was much faster for pH 7.3 than that for pH 5.5. In this way, the mechanism involved in the release could be either Fickian or non-Fickian depending on the pH environment. The simple and efficient strategy presented here to develop antimicrobial nanofibrous membrane make them promising for drug delivery carrier and wound dressing applications.
653 $aDrug delivery
653 $aElectrospinning
653 $aModulated release
700 1 $aMERCANTE, L. A.
700 1 $aANDRE, R. S.
700 1 $aBRANDÃO, H. M.
700 1 $aMATTOSO, L. H. C.
700 1 $aCORREA, D. S.
773 $tReactive and Functional Polymers$gn. 132, p. 26-35, nov. 2018.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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Biblioteca |
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Origem |
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Classificação |
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Registro |
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URL |
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Registro Completo
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Biblioteca(s): |
Embrapa Arroz e Feijão. |
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Data corrente: |
08/12/2011 |
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Data da última atualização: |
08/12/2011 |
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Autoria: |
OLIVEIRA, M. D. de; BARBOSA, F. R.; ALMEIDA-CORTEZ, J.; SILVEIRA, L. C. P. |
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Afiliação: |
MARTIN DUARTE DE OLIVEIRA, UNIVERSIDADE FEDERAL RURAL DE PERNAMBUCO; FLAVIA RABELO BARBOSA MOREIRA, CNPAF; JARCILENE ALMEIDA-CORTEZ, UNIVERSIDADE FEDERAL DE PERNAMBUCO; LUÍS CLÁUDIO PATERNO SILVEIRA, UFLA. |
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Título: |
Espécies de Frankliniella (Thysanoptera, Thripidae): novos registros em mangueira (Mangifera indica) no Brasil. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Ciência Rural, Santa Maria, v. 41, n. 10, p. 1709-1711, out. 2011. |
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Idioma: |
Português |
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Conteúdo: |
O objetivo do trabalho foi conhecer as espécies de tripes (Thysanoptera) que atacam pomares de mangueira no semiárido pernambucano. Foram realizadas coletas no período de um ano, em três plantios comerciais da cv. ?Tommy Atkins?. Avaliações semanais foram realizadas em 75 plantas, nos estádios vegetativo e reprodutivo, perfazendo um total de 10.704 amostras em folhas e 390 em panículas. Os espécimes coletados foram levados ao laboratório da Embrapa Semiárido, Petrolina, PE, para triagem dos adultos em microscópio estereoscópico e, posteriormente, enviados à Universidade Federal de Lavras, MG, para identificação. As espécies Frankliniella gardeniae Moulton e Frankliniella Brevicaulis Hood, pertencentes à família Thripidae, representaram, respectivamente, 77% e 23% do total dos tripes coletados. Este estudo relata a primeira ocorrência dessas duas espécies em associação à cultura da mangueira, no Brasil. |
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Palavras-Chave: |
Trips. |
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Thesagro: |
Doença de planta; Fruta tropical; Manga. |
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Thesaurus NAL: |
Frankliniella. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/49789/1/a13111cr47461.pdf
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Marc: |
LEADER 01610naa a2200217 a 4500
001 1909121
005 2011-12-08
008 2011 bl uuuu u00u1 u #d
100 1 $aOLIVEIRA, M. D. de
245 $aEspécies de Frankliniella (Thysanoptera, Thripidae)$bnovos registros em mangueira (Mangifera indica) no Brasil.$h[electronic resource]
260 $c2011
520 $aO objetivo do trabalho foi conhecer as espécies de tripes (Thysanoptera) que atacam pomares de mangueira no semiárido pernambucano. Foram realizadas coletas no período de um ano, em três plantios comerciais da cv. ?Tommy Atkins?. Avaliações semanais foram realizadas em 75 plantas, nos estádios vegetativo e reprodutivo, perfazendo um total de 10.704 amostras em folhas e 390 em panículas. Os espécimes coletados foram levados ao laboratório da Embrapa Semiárido, Petrolina, PE, para triagem dos adultos em microscópio estereoscópico e, posteriormente, enviados à Universidade Federal de Lavras, MG, para identificação. As espécies Frankliniella gardeniae Moulton e Frankliniella Brevicaulis Hood, pertencentes à família Thripidae, representaram, respectivamente, 77% e 23% do total dos tripes coletados. Este estudo relata a primeira ocorrência dessas duas espécies em associação à cultura da mangueira, no Brasil.
650 $aFrankliniella
650 $aDoença de planta
650 $aFruta tropical
650 $aManga
653 $aTrips
700 1 $aBARBOSA, F. R.
700 1 $aALMEIDA-CORTEZ, J.
700 1 $aSILVEIRA, L. C. P.
773 $tCiência Rural, Santa Maria$gv. 41, n. 10, p. 1709-1711, out. 2011.
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Embrapa Arroz e Feijão (CNPAF) |
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