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Registro Completo |
Biblioteca(s): |
Embrapa Rondônia. |
Data corrente: |
14/08/2013 |
Data da última atualização: |
14/08/2013 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
AKBAR, H.; SCHMITT, E.; BALLOU, M. A.; CORRÊA, M. N.; DEPETERS, E. J.; LOOR, J. J. |
Afiliação: |
haji Akbar, University of illinois, Urbana; EDUARDO SCHMITT, CPAF-RO; Michael A. Ballou, Texas Tech University; Marcio N. Corrêa, NUPeeC, UFPel; Edward J. DePeter, University of California; Juan J. Loor, University of illinois, Urbana. |
Título: |
Dietary Lipid During Late-pregnancy and early-Lactation to Manipulate Metabolic and Inflammatory Gene Network Expression in Dairy Cattle Liver with a Focus on PPARs. |
Ano de publicação: |
2013 |
Fonte/Imprenta: |
Gene Regulation and Systems Biology, v. 7, p. 103?123, 2013. |
Idioma: |
Inglês |
Conteúdo: |
Polyunsaturated (PUFA) long-chain fatty acids (LCFAs) are more potent in eliciting molecular and tissue functional changes in monogastrics than saturated LCFA. From −21 through 10 days relative to parturition dairy cows were fed no supplemental LCFA (control), saturated LCFA (SFAT; mainly 16:0 and 18:0), or fish oil (FISH; high-PUFA). Twenty-seven genes were measured via quantitative RT-PCR in liver tissue on day −14 and day 10. Expression of nuclear receptor co-activators (CARM1, MED1), LCFA metabolism (ACSL1, SCD, ACOX1), and inflammation (IL6, TBK1, IKBKE) genes was lower with SFAT than control on day −14. Expression of SCD, however, was markedly lower with FISH than control or SFAT on both −14 and 10 days. FISH led to further decreases in expression on day 10 of LCFA metabolism (CD36, PLIN2, ACSL1, ACOX1), intracellular energy (UCP2, STK11, PRKAA1), de novo cholesterol synthesis (SREBF2), inflammation (IL6, TBK1, IKBKE), and nuclear receptor signaling genes (PPARD, MED1, NRIP1). No change in expression was observed for PPARA and RXRA. The increase of DGAT2, PLIN2, ACSL1, and ACOX1 on day 10 versus −14 in cows fed SFAT suggested upregulation of both beta-oxidation and lipid droplet (LD) formation. However, liver triacylglycerol concentration was similar among treatments. The hepatokine FGF21 and the gluconeogenic genes PC and PCK1 increased markedly on day 10 versus −14 only in controls. At the levels supplemented, the change in the profile of metabolic genes after parturition in cows fed saturated fat suggested a greater capacity for uptake of fatty acids and intracellular handling without excessive storage of LD. MenosPolyunsaturated (PUFA) long-chain fatty acids (LCFAs) are more potent in eliciting molecular and tissue functional changes in monogastrics than saturated LCFA. From −21 through 10 days relative to parturition dairy cows were fed no supplemental LCFA (control), saturated LCFA (SFAT; mainly 16:0 and 18:0), or fish oil (FISH; high-PUFA). Twenty-seven genes were measured via quantitative RT-PCR in liver tissue on day −14 and day 10. Expression of nuclear receptor co-activators (CARM1, MED1), LCFA metabolism (ACSL1, SCD, ACOX1), and inflammation (IL6, TBK1, IKBKE) genes was lower with SFAT than control on day −14. Expression of SCD, however, was markedly lower with FISH than control or SFAT on both −14 and 10 days. FISH led to further decreases in expression on day 10 of LCFA metabolism (CD36, PLIN2, ACSL1, ACOX1), intracellular energy (UCP2, STK11, PRKAA1), de novo cholesterol synthesis (SREBF2), inflammation (IL6, TBK1, IKBKE), and nuclear receptor signaling genes (PPARD, MED1, NRIP1). No change in expression was observed for PPARA and RXRA. The increase of DGAT2, PLIN2, ACSL1, and ACOX1 on day 10 versus −14 in cows fed SFAT suggested upregulation of both beta-oxidation and lipid droplet (LD) formation. However, liver triacylglycerol concentration was similar among treatments. The hepatokine FGF21 and the gluconeogenic genes PC and PCK1 increased markedly on day 10 versus −14 only in controls. At the levels supplemented, the change in the pro... Mostrar Tudo |
Palavras-Chave: |
Fat supplementation; Hepatic gene network; Rede de gene hepática; Suplementação de gordura; Vacas leiteiras. |
Thesaurus Nal: |
dairy cows. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 02512naa a2200253 a 4500 001 1964101 005 2013-08-14 008 2013 bl uuuu u00u1 u #d 100 1 $aAKBAR, H. 245 $aDietary Lipid During Late-pregnancy and early-Lactation to Manipulate Metabolic and Inflammatory Gene Network Expression in Dairy Cattle Liver with a Focus on PPARs.$h[electronic resource] 260 $c2013 520 $aPolyunsaturated (PUFA) long-chain fatty acids (LCFAs) are more potent in eliciting molecular and tissue functional changes in monogastrics than saturated LCFA. From −21 through 10 days relative to parturition dairy cows were fed no supplemental LCFA (control), saturated LCFA (SFAT; mainly 16:0 and 18:0), or fish oil (FISH; high-PUFA). Twenty-seven genes were measured via quantitative RT-PCR in liver tissue on day −14 and day 10. Expression of nuclear receptor co-activators (CARM1, MED1), LCFA metabolism (ACSL1, SCD, ACOX1), and inflammation (IL6, TBK1, IKBKE) genes was lower with SFAT than control on day −14. Expression of SCD, however, was markedly lower with FISH than control or SFAT on both −14 and 10 days. FISH led to further decreases in expression on day 10 of LCFA metabolism (CD36, PLIN2, ACSL1, ACOX1), intracellular energy (UCP2, STK11, PRKAA1), de novo cholesterol synthesis (SREBF2), inflammation (IL6, TBK1, IKBKE), and nuclear receptor signaling genes (PPARD, MED1, NRIP1). No change in expression was observed for PPARA and RXRA. The increase of DGAT2, PLIN2, ACSL1, and ACOX1 on day 10 versus −14 in cows fed SFAT suggested upregulation of both beta-oxidation and lipid droplet (LD) formation. However, liver triacylglycerol concentration was similar among treatments. The hepatokine FGF21 and the gluconeogenic genes PC and PCK1 increased markedly on day 10 versus −14 only in controls. At the levels supplemented, the change in the profile of metabolic genes after parturition in cows fed saturated fat suggested a greater capacity for uptake of fatty acids and intracellular handling without excessive storage of LD. 650 $adairy cows 653 $aFat supplementation 653 $aHepatic gene network 653 $aRede de gene hepática 653 $aSuplementação de gordura 653 $aVacas leiteiras 700 1 $aSCHMITT, E. 700 1 $aBALLOU, M. A. 700 1 $aCORRÊA, M. N. 700 1 $aDEPETERS, E. J. 700 1 $aLOOR, J. J. 773 $tGene Regulation and Systems Biology$gv. 7, p. 103?123, 2013.
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Embrapa Rondônia (CPAF-RO) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Arroz e Feijão. Para informações adicionais entre em contato com cnpaf.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Arroz e Feijão. |
Data corrente: |
09/04/2002 |
Data da última atualização: |
08/04/2005 |
Autoria: |
OLIVEIRA, I. P. de; CARVALHO, A. M. de. |
Título: |
Climate and soils of the cowpea producing regions. |
Ano de publicação: |
1988 |
Fonte/Imprenta: |
In: WATT, E. E.; ARAÚJO, J. P. P. de. Cowpea research in Brazil. Brasília, DF: IITA: EMBRAPA, 1988. |
Páginas: |
p. 11-29. |
Idioma: |
Inglês |
Conteúdo: |
Climatic conditions required by cowpea; Climate of the humid tropics (North); Climate of the Semiarid tropics (Northeast region); Soils; Influence of climate and soil on cowpea cultivation. |
Palavras-Chave: |
Caupi; Cowpea. |
Thesagro: |
Clima; Produção; Solo. |
Thesaurus NAL: |
soil. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00766naa a2200217 a 4500 001 1209589 005 2005-04-08 008 1988 bl uuuu u00u1 u #d 100 1 $aOLIVEIRA, I. P. de 245 $aClimate and soils of the cowpea producing regions. 260 $c1988 300 $ap. 11-29. 520 $aClimatic conditions required by cowpea; Climate of the humid tropics (North); Climate of the Semiarid tropics (Northeast region); Soils; Influence of climate and soil on cowpea cultivation. 650 $asoil 650 $aClima 650 $aProdução 650 $aSolo 653 $aCaupi 653 $aCowpea 700 1 $aCARVALHO, A. M. de 773 $tIn: WATT, E. E.; ARAÚJO, J. P. P. de. Cowpea research in Brazil. Brasília, DF: IITA: EMBRAPA, 1988.
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