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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
04/09/2019 |
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Data da última atualização: |
09/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SANTOS, R. M. dos; FERNANDO, F. S.; MONTASSIER, M. de F. S.; SILVA, K. R.; LOEPS, P. D.; PAVANI, C.; BORZI, M. M.; OKINO, C. H.; MONTASSIER, H. J. |
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Afiliação: |
Romeu Moreira dos Santos, UNESP; Filipe Santos Fernando, UNESP; Maria de Fátima Silva Montassier, UNESP; Ketherson Rodrigues Silva, UNESP; Priscila Diniz Lopes, UNESP; Caren Pavani, UNESP; Mariana Monezi Borzi, UNESP; CINTIA HIROMI OKINO, CPPSE; Helio José Montassier, UNESP. |
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Título: |
Memory immune responses and protection of chickens against a nephropathogenic infectious bronchitis virus strain by combining live heterologous and inactivated homologous vaccines. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
The Journal of Veterinary Medical Science, v.81, n.4, p.612-619, 2019. |
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DOI: |
10.1292/jvms.18-0065 |
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Idioma: |
Inglês |
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Conteúdo: |
In this study, we evaluated antibody and cell-mediated immune (CMI) responses in the mucosal and systemic compartments and protection against challenge with a nephropathogenic Brazilian (BR-I) strain of infectious bronchitis virus (IBV) in chickens submitted to a vaccination regime comprising a priming dose of heterologous live attenuated Massachusetts vaccine followed by a booster dose of an experimental homologous inactivated vaccine two weeks later. This immunization protocol elicited significant increases in serum and lachrymal levels of anti-IBV IgG antibodies and upregulated the expression of CMI response genes, such as those encoding CD8? chain and Granzyme homolog A in tracheal and kidney tissues at 3, 7, and 11 days post-infection in the vaccinated chickens. Additionally, vaccinated and challenged chickens showed reduced viral loads and microscopic lesion counts in tracheal and kidney tissues, and their antibody and CMI responses were negatively correlated with viral loads in the trachea and kidney. In conclusion, the combination of live attenuated vaccine containing the Massachusetts strain with a booster dose of an inactivated vaccine, containing a BR-I IBV strain, confers effective protection against infection with nephropathogenic homologous IBV strain because of the induction of consistent memory immune responses mediated by IgG antibodies and TCD8 cells in the mucosal and systemic compartments of chickens submitted to this vaccination regime. |
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Palavras-Chave: |
Cell mediated immunity; Oil adjuvant. |
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Thesaurus Nal: |
Avian coronavirus; Humoral immunity; Mucosal immunity. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/201566/1/Memory-Immune-Responses.pdf
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Marc: |
LEADER 02441naa a2200289 a 4500
001 2111878
005 2020-01-09
008 2019 bl uuuu u00u1 u #d
024 7 $a10.1292/jvms.18-0065$2DOI
100 1 $aSANTOS, R. M. dos
245 $aMemory immune responses and protection of chickens against a nephropathogenic infectious bronchitis virus strain by combining live heterologous and inactivated homologous vaccines.$h[electronic resource]
260 $c2019
520 $aIn this study, we evaluated antibody and cell-mediated immune (CMI) responses in the mucosal and systemic compartments and protection against challenge with a nephropathogenic Brazilian (BR-I) strain of infectious bronchitis virus (IBV) in chickens submitted to a vaccination regime comprising a priming dose of heterologous live attenuated Massachusetts vaccine followed by a booster dose of an experimental homologous inactivated vaccine two weeks later. This immunization protocol elicited significant increases in serum and lachrymal levels of anti-IBV IgG antibodies and upregulated the expression of CMI response genes, such as those encoding CD8? chain and Granzyme homolog A in tracheal and kidney tissues at 3, 7, and 11 days post-infection in the vaccinated chickens. Additionally, vaccinated and challenged chickens showed reduced viral loads and microscopic lesion counts in tracheal and kidney tissues, and their antibody and CMI responses were negatively correlated with viral loads in the trachea and kidney. In conclusion, the combination of live attenuated vaccine containing the Massachusetts strain with a booster dose of an inactivated vaccine, containing a BR-I IBV strain, confers effective protection against infection with nephropathogenic homologous IBV strain because of the induction of consistent memory immune responses mediated by IgG antibodies and TCD8 cells in the mucosal and systemic compartments of chickens submitted to this vaccination regime.
650 $aAvian coronavirus
650 $aHumoral immunity
650 $aMucosal immunity
653 $aCell mediated immunity
653 $aOil adjuvant
700 1 $aFERNANDO, F. S.
700 1 $aMONTASSIER, M. de F. S.
700 1 $aSILVA, K. R.
700 1 $aLOEPS, P. D.
700 1 $aPAVANI, C.
700 1 $aBORZI, M. M.
700 1 $aOKINO, C. H.
700 1 $aMONTASSIER, H. J.
773 $tThe Journal of Veterinary Medical Science$gv.81, n.4, p.612-619, 2019.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria Tropical. Para informações adicionais entre em contato com cnpat.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Agroindústria Tropical. |
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Data corrente: |
30/12/2019 |
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Data da última atualização: |
19/02/2020 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
FIGUEIREDO, M. C. B. de; BARROS, V. da S.; SANTOS, T. de L.; GONDIM, R. S.; SOUSA, J. A. de; ARAGAO, F. A. S. de. |
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Afiliação: |
MARIA CLEA BRITO DE FIGUEIREDO, CNPAT; Viviane da Silva Barros, CAPES-EMBRAPA; Tayane de Lima Santos, Universidade Federal do Ceará (UFC); RUBENS SONSOL GONDIM, CNPAT; JOAO ALENCAR DE SOUSA, CNPAT; FERNANDO ANTONIO SOUZA DE ARAGAO, CNPAT. |
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Título: |
Pegada de carbono do melão amarelo exportado. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
In: GUIMARÃES, M. de A.; ARAGÃO, F. A. S. de (Ed.). Produção de melão. Viçosa, MG: Universidade Federal de Viçosa, 2019. |
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Volume: |
cap. 24 |
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Páginas: |
p. 396-424. |
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Idioma: |
Português |
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Palavras-Chave: |
Melão amarelo. |
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Thesagro: |
Carbono; Melão. |
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Thesaurus NAL: |
Carbon; Melons. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00761naa a2200253 a 4500
001 2117871
005 2020-02-19
008 2019 bl uuuu u00u1 u #d
100 1 $aFIGUEIREDO, M. C. B. de
245 $aPegada de carbono do melão amarelo exportado.$h[electronic resource]
260 $c2019
300 $ap. 396-424. cap. 24
490 $vcap. 24
650 $aCarbon
650 $aMelons
650 $aCarbono
650 $aMelão
653 $aMelão amarelo
700 1 $aBARROS, V. da S.
700 1 $aSANTOS, T. de L.
700 1 $aGONDIM, R. S.
700 1 $aSOUSA, J. A. de
700 1 $aARAGAO, F. A. S. de
773 $tIn: GUIMARÃES, M. de A.; ARAGÃO, F. A. S. de (Ed.). Produção de melão. Viçosa, MG: Universidade Federal de Viçosa, 2019.
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Embrapa Agroindústria Tropical (CNPAT) |
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