Data/hora: 08/06/2024 15:20:53

Biblioteca(s): 	Embrapa Meio Norte / UEP-Parnaíba.	
Data corrente: 	18/07/1996	
Data da última atualização: 	18/07/1996	
Autoria: 	SANTANA, J. M.; TEIXEIRA, A. R. L.	
Afiliação: 	University of Brasilia.	
Título: 	Effect of immunotoxins against Trypanosoma cruzi.	
Ano de publicação: 	1989	
Fonte/Imprenta: 	American Journal of Tropical Medicine and Hygiene, v.41, n.2, p.177-182, 1989.	
Idioma: 	Inglês	
Conteúdo: 	Immunotoxins were constructed with IgG antibodies against Trupanosoma cruzi surface antigens  by hybridization with abrin (ITA) and ricin (ITR) A chains. The biological activity of the hybrid macromolecules wastested on the parasite forms. Mortility of parasite forms was lost in vitro after incubation with ITR. In general, killing of the parasite with ITR was more efficient than with ITA. Inhibition of protein synthesis after incubation with either ITR or ITA, measured by 3H-leucine incorporation, confirmed the parasite immobilization experiments. The lethal effect was potentiated when the immunotoxins were used in the presence of 2.5 mM ammonium chloride. T. cruzi antibodies specific to cell surface antigens are excellent  drug carriers that can be deliveredto the target cell. However, ITR and ITA did not reduce parasitemia orincrease survival of mice infected  with T.cruzi.	
Thesagro: 	Trypanosoma Cruzi.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Meio Norte / UEP-Parnaíba (CPAMN-UEPP)	
Exemplares: 	CPAMN-UEPP - (6854-1) - ADC - SP - -- -  -  - 1996.00176 - DIS