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Registro Completo |
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Biblioteca(s): |
Embrapa Alimentos e Territórios. |
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Data corrente: |
09/05/2023 |
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Data da última atualização: |
29/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SABINO, L. B. de S.; COPES, F.; SAULAIS, S.; BRITO, E. S. de; SILVA JÚNIOR, I. J. da; LE, T. C.; MATEESCU, M. A.; MANTOVANI, D. |
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Afiliação: |
LUIZ BRUNO DE SOUSA SABINO, UFC; FRANCESCO COPES, Laval University; SOLÈNE SAULAIS, Université du Québec à Montréal; EDY SOUSA DE BRITO, CNAT; IVANILDO JOSÉ DA SILVA JÚNIOR, UFC; TIEN CANH LE, Université du Québec à Montréal; MIRCEA ALEXANDRU MATEESCU, Université du Québec à Montréal; DIEGO MANTOVANI, Laval University. |
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Título: |
Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Molecules, v. 27, n. 21, 7271, p. 1-19, 2022. |
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ISSN: |
1420-3049 |
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DOI: |
https://doi.org/10.3390/molecules27217271 |
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Idioma: |
Inglês |
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Conteúdo: |
Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity. |
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Palavras-Chave: |
Agente bioativo; Antiaterosclerótica; Antiatherosclerotic activities; Antiinflammatory; Antioxidant activities; Antioxidantes; Antitumoral; Bioactive agent delivery; Carboxymethyl starch; Jamelão; Monolithic tablets. |
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Thesagro: |
Antiinflamatório; Fruto. |
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Thesaurus Nal: |
Anthocyanins; Fruit composition; Syzygium cumini. |
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Categoria do assunto: |
S Ciências Biológicas |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1153621/1/CNAT-9.pdf
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Marc: |
LEADER 02218naa a2200421 a 4500
001 2153621
005 2024-02-29
008 2022 bl uuuu u00u1 u #d
022 $a1420-3049
024 7 $ahttps://doi.org/10.3390/molecules27217271$2DOI
100 1 $aSABINO, L. B. de S.
245 $aAnthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery.$h[electronic resource]
260 $c2022
520 $aAnthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.
650 $aAnthocyanins
650 $aFruit composition
650 $aSyzygium cumini
650 $aAntiinflamatório
650 $aFruto
653 $aAgente bioativo
653 $aAntiaterosclerótica
653 $aAntiatherosclerotic activities
653 $aAntiinflammatory
653 $aAntioxidant activities
653 $aAntioxidantes
653 $aAntitumoral
653 $aBioactive agent delivery
653 $aCarboxymethyl starch
653 $aJamelão
653 $aMonolithic tablets
700 1 $aCOPES, F.
700 1 $aSAULAIS, S.
700 1 $aBRITO, E. S. de
700 1 $aSILVA JÚNIOR, I. J. da
700 1 $aLE, T. C.
700 1 $aMATEESCU, M. A.
700 1 $aMANTOVANI, D.
773 $tMolecules$gv. 27, n. 21, 7271, p. 1-19, 2022.
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Registro original: |
Embrapa Alimentos e Territórios (CNAT) |
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| Registros recuperados : 6 | |
| 3. |  | SABINO, L. B. de S.; COPES, F.; SAULAIS, S.; BRITO, E. S. de; SILVA JÚNIOR, I. J. da; LE, T. C.; MATEESCU, M. A.; MANTOVANI, D. Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery. Molecules, v. 27, n. 21, 7271, p. 1-19, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Alimentos e Territórios. |
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| 4. | | OLIVEIRA, L. M. N. de; BASTOS, M. do S. R.; LIMA, A. C. S. de; FIGUEIREDO, E. A. T. de; DIAS, F. G. B.; SILVA, L. M. R. da; BENEVIDES, S. D.; RIBEIRO, P. R. V.; SABINO, L. B. de S.; FIGUEIREDO, R. W. de. Chemical characterization, cytotoxicity, antimicrobial and antioxidant potential of Justicia pectoralis Jacq and Croton jacobinensis Baill extracts. Brazilian Journal of Pharmaceutical Sciences, 59: e21224, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 5. | | SABINO, L. B. DE S.; GONZAGA, M. L. DA C.; OLIVEIRA, L. DE S.; DUARTE, A. S. G.; SILVA, L. M. A. e; BRITO, E. S. de; FIGUEIREDO, R. W. DE; SILVA, L. M. R. DA; SOUSA, P. H. M. DE. Polysaccharides from acerola, cashew apple, pineapple, mango and passion fruit co-products: structure, cytotoxicity and gastroprotective effects. Bioactive Carbohydrates and Dietary Fibre, [Amsterdam], v. 24, artigo 100228, 11 p., Oct. 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 6. | | GUIMARAES, T. L. F.; SILVA, L. M. R. da; MUNIZ, C. R.; VIEIRA, I. G. P.; OLIVEIRA, L. S. de; DIAS, F. G. B.; LIMA, C. de B.; GONZAGA, M. L. da C.; LIMA, J. da S. S.; SABINO, L. B. de S.; FIGUEIREDO, E. A. T. de. Potential of chambá (Justicia Pectoralis Jacq.) leaves extracts as a source of bioactive compounds and natural antimicrobial agent. Food Chemistry Advances, 3, 100367 2023.| Tipo: Artigo em Periódico Indexado |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| Registros recuperados : 6 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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