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Registro Completo |
Biblioteca(s): |
Embrapa Agroenergia. |
Data corrente: |
01/10/2015 |
Data da última atualização: |
20/09/2017 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
NISHIJIMA, C. M.; DELELLA, F. K.; RODRIGUES, C. M.; RINALDO, D.; LOPES-FERREIRA, M. V. dos Anjos; ROCHA, L. R. M. da; VILEGAS, W.; FELISBINO, S. L.; HIRUMA-LIMA, C. A. |
Afiliação: |
Catarine Massucato Nishijima, UNESP; Flavia Karina Delella, UNESP; CLENILSON MARTINS RODRIGUES, CNPAE; Daniel Rinaldo, UNESP; Monica Valdyrce dos Anjos Lopes-Ferreira, Instituto Butantan; Lucia Regina Machado da Rocha, UNESP; Wagner Vilegas, UNESP; Sergio Luis Felisbino, UNESP; Clélia Akiko Hiruma-Lima, UNESP. |
Título: |
The anti-inflammatory effects of the methanolic extract and fractions from Davilla elliptica St Hil (Dilleniaceae) on Bothrops jararaca envenomation. |
Ano de publicação: |
2015 |
Fonte/Imprenta: |
International Journal of Molecular Sciences, v. 16, n. 6, 2015 |
DOI: |
10.3390/ijms160612454 |
Idioma: |
Inglês |
Conteúdo: |
Inflammation and haemorrhage are the main characteristics of tissue injury in botropic envenomation. Although some studies have shown that anti-venom prevents systemic reactions, it is not efficient in preventing tissue injury at the site of the bite. Therefore, this work was undertaken to investigate the anti-inflammatory effects of the methanolic extract and fractions from D. elliptica and to evaluate the role of matrix metalloproteinases (MMPs) in this process. Effects of the extract and fractions from D. elliptica were evaluated using a carrageenan-induced paw oedema model in rats, and leukocyte rolling was visualized by intravital. The quantification of MMPs activities (MMP-2 and MMP-9) extracted from the dermis of mice treated with extract and fractions alone or incubated with venom was determined by zymographic analyses. Our results show that intraperitoneal (i.p.) injection of fractions significantly reduced paw oedema after the carrageenan challenge. Treatment with the tannins fraction also resulted in considerable inhibition of the rolling of leukocytes and this fraction was able to decrease the activation of MMP-9. These results confirmed the anti-inflammatory activity of the methanolic extract and tannins fraction of D. elliptica and showed that the dermonecrosis properties of B. jararaca venom might be mediated through the inhibition of MMP-9 activity. |
Palavras-Chave: |
Anti-inflammatory effect; Bothrops jararaca venom; Davilla elliptica St Hil; Efeito antiinflamatório; MMP-9; MP-2; Veneno Bothrops jararaca. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02409naa a2200313 a 4500 001 2025612 005 2017-09-20 008 2015 bl uuuu u00u1 u #d 024 7 $a10.3390/ijms160612454$2DOI 100 1 $aNISHIJIMA, C. M. 245 $aThe anti-inflammatory effects of the methanolic extract and fractions from Davilla elliptica St Hil (Dilleniaceae) on Bothrops jararaca envenomation.$h[electronic resource] 260 $c2015 520 $aInflammation and haemorrhage are the main characteristics of tissue injury in botropic envenomation. Although some studies have shown that anti-venom prevents systemic reactions, it is not efficient in preventing tissue injury at the site of the bite. Therefore, this work was undertaken to investigate the anti-inflammatory effects of the methanolic extract and fractions from D. elliptica and to evaluate the role of matrix metalloproteinases (MMPs) in this process. Effects of the extract and fractions from D. elliptica were evaluated using a carrageenan-induced paw oedema model in rats, and leukocyte rolling was visualized by intravital. The quantification of MMPs activities (MMP-2 and MMP-9) extracted from the dermis of mice treated with extract and fractions alone or incubated with venom was determined by zymographic analyses. Our results show that intraperitoneal (i.p.) injection of fractions significantly reduced paw oedema after the carrageenan challenge. Treatment with the tannins fraction also resulted in considerable inhibition of the rolling of leukocytes and this fraction was able to decrease the activation of MMP-9. These results confirmed the anti-inflammatory activity of the methanolic extract and tannins fraction of D. elliptica and showed that the dermonecrosis properties of B. jararaca venom might be mediated through the inhibition of MMP-9 activity. 653 $aAnti-inflammatory effect 653 $aBothrops jararaca venom 653 $aDavilla elliptica St Hil 653 $aEfeito antiinflamatório 653 $aMMP-9 653 $aMP-2 653 $aVeneno Bothrops jararaca 700 1 $aDELELLA, F. K. 700 1 $aRODRIGUES, C. M. 700 1 $aRINALDO, D. 700 1 $aLOPES-FERREIRA, M. V. dos Anjos 700 1 $aROCHA, L. R. M. da 700 1 $aVILEGAS, W. 700 1 $aFELISBINO, S. L. 700 1 $aHIRUMA-LIMA, C. A. 773 $tInternational Journal of Molecular Sciences$gv. 16, n. 6, 2015
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Registro original: |
Embrapa Agroenergia (CNPAE) |
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Registro Completo
Biblioteca(s): |
Embrapa Trigo. |
Data corrente: |
20/12/1999 |
Data da última atualização: |
14/09/2015 |
Autoria: |
SÓ e SILVA, M.; MINELLA, E.; ARIAS, G.; LINHARES, A. G.; HUGEL, H.; ALMEIDA, J. L. |
Afiliação: |
1-4 Embrapa Trigo; 5-6 FAPA, Fundação Agrária de Pesquisa Agropecuária, Cooperativa Agrária Entre Rios Ltda, Guarapuava. |
Título: |
Caracterização e avaliação de linhagens de cevada cervejeira do banco ativo de germoplasma da Embrapa Trigo. |
Ano de publicação: |
1999 |
Fonte/Imprenta: |
In: REUNIÃO ANUAL DE PESQUISA DE CEVADA, 19., 1999, Passo Fundo. Anais... Passo Fundo: Embrapa Trigo, 1999. |
Páginas: |
p. 306-325 |
Série: |
(Embrapa Trigo. Documentos, 5). |
ISSN: |
1516-5582 |
Idioma: |
Português |
Thesagro: |
Cevada. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/129555/1/ID13472-reuniaocevadadoc5-p306-325.pdf
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Marc: |
LEADER 00696naa a2200217 a 4500 001 1825269 005 2015-09-14 008 1999 bl uuuu u00u1 u #d 022 $a1516-5582 100 1 $aSÓ e SILVA, M. 245 $aCaracterização e avaliação de linhagens de cevada cervejeira do banco ativo de germoplasma da Embrapa Trigo. 260 $c1999 300 $ap. 306-325 490 $a(Embrapa Trigo. Documentos, 5). 650 $aCevada 700 1 $aMINELLA, E. 700 1 $aARIAS, G. 700 1 $aLINHARES, A. G. 700 1 $aHUGEL, H. 700 1 $aALMEIDA, J. L. 773 $tIn: REUNIÃO ANUAL DE PESQUISA DE CEVADA, 19., 1999, Passo Fundo. Anais... Passo Fundo: Embrapa Trigo, 1999.
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