Data/hora: 06/06/2024 15:07:21

Biblioteca(s): | Embrapa Meio Norte / UEP-Parnaíba.
Data corrente: | 19/08/1996
Data da última atualização: | 19/08/1996
Autoria: | RIBEIRO-DASILVA, C.R.; CARLINI, C. R.; PIRES-BARBOSA, R.; GUIMARAES, J. A.
Título: | Blood glucose alterations induced in rats by canatoxin, a protein isolated from jack bean (Canavalia ensiformis) seeds.
Ano de publicação: | 1986
Fonte/Imprenta: | Toxicon, v.24, n.8, p.775-782, 1986.
Idioma: | Inglês
Conteúdo: | Canatoxin, a lethal convulsant protein isolated from the seeds of Canatoxin ensiformis (Jack bean), induced a biphasis alterations in blood glucose levels when injected j.v. into rats and mice. After administration of subconvulsant doses of canatoxin the rats showed initially hyperglycemia during the first 30 min. Followed by a long-lasting hypoglycemia. Return to basal glucose levels was not seen up to 15 days. The hyperglycemic effect was dose-dependent and occurred in starved and well-fed animals. A parallelism between convulsant  and hyperglycemic was observed throughout all canatoxin purification steps. Mice were about 20-fold  less sensitive (on a weight basis) than rats to canatoxin-induced hyperglycemia. The hyperglycemia phase was not as affected by pretreatment on the rats with alpha or beta-adrenergic blockers or chlorpromazine, but was potentially by reserpine and haloperidol. Diazepan and hexamethonium were able to block the hyperglymic phase of canatoxin's effect. The results suggest that the hyperglycemic alterations induced by canatoxin in rats and mice are probably mediated via the central nervous system.
Palavras-Chave: | Bean; Isolated protein; Proteina isolada.
Thesagro: | Canavalia Ensiformis; Feijão; Phaseolus Vulgaris.
Categoria do assunto: | --
Registro original: | Embrapa Meio Norte / UEP-Parnaíba (CPAMN-UEPP)
Exemplares: | CPAMN-UEPP - (6983-1) - ADC - SP - -- -  -  - 1996.00198 - DIS