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Registro Completo |
Biblioteca(s): |
Embrapa Suínos e Aves. |
Data corrente: |
03/08/2021 |
Data da última atualização: |
03/08/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
FERNANDES, A. C.; SILVA, V. H. da; GOES, C. P.; MOREIRA, G. C. M.; GODOY, T. F.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; LEDUR, M. C.; REZENDE, F. M. de; COUTINHO, L. L. |
Afiliação: |
ANNA CAROLINA FERNANDES, ESALQ; VINICIUS HENRIQUE DA SILVA, ESALQ; CAROLINA PURCELL GOES, ESALQ; GABRIEL COSTA MONTEIRO MOREIRA, University of Liège; THAIS FERNANDA GODOY, ESALQ; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; MONICA CORREA LEDUR, CNPSA; FERNANDA MARCONDES REZENDE, University of Florida; LUIZ LEHMANN COUTINHO, ESALQ. |
Título: |
Genome-wide detection of CNVs and their association with performance traits in broilers. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
BMC Genomics, v. 22, n. 354, 2021. |
DOI: |
https://doi.org/10.1186/s12864-021-07676-1 |
Idioma: |
Inglês |
Conteúdo: |
Abstract Background: Copy number variations (CNVs) are a major type of structural genomic variants that underlie genetic architecture and phenotypic variation of complex traits, not only in humans, but also in livestock animals. We identified CNVs along the chicken genome and analyzed their association with performance traits. Genome-wide CNVs were inferred from Affymetrix® high density SNP-chip data for a broiler population. CNVs were concatenated into segments and association analyses were performed with linear mixed models considering a genomic relationship matrix, for birth weight, body weight at 21, 35, 41 and 42 days, feed intake from 35 to 41 days, feed conversion ratio from 35 to 41 days and, body weight gain from 35 to 41 days of age. Results: We identified 23,214 autosomal CNVs, merged into 5042 distinct CNV regions (CNVRs), covering 12.84% of the chicken autosomal genome. One significant CNV segment was associated with BWG on GGA3 (q-value = 0.00443); one significant CNV segment was associated with BW35 (q-value = 0.00571), BW41 (q-value = 0.00180) and BW42 (q-value = 0.00130) on GGA3, and one significant CNV segment was associated with BW on GGA5 (q-value = 0.00432). All significant CNV segments were verified by qPCR, and a validation rate of 92.59% was observed. These CNV segments are located nearby genes, such as KCNJ11, MyoD1 and SOX6, known to underlie growth and development. Moreover, gene-set analyses revealed terms linked with muscle physiology, cellular processes regulation and potassium channels. Conclusions: Overall, this CNV-based GWAS study unravels potential candidate genes that may regulate performance traits in chickens. Our findings provide a foundation for future functional studies on the role of specific genes in regulating performance in chickens. Keywords: GWAS, Performance, CNVs, QTLs, qPCR MenosAbstract Background: Copy number variations (CNVs) are a major type of structural genomic variants that underlie genetic architecture and phenotypic variation of complex traits, not only in humans, but also in livestock animals. We identified CNVs along the chicken genome and analyzed their association with performance traits. Genome-wide CNVs were inferred from Affymetrix® high density SNP-chip data for a broiler population. CNVs were concatenated into segments and association analyses were performed with linear mixed models considering a genomic relationship matrix, for birth weight, body weight at 21, 35, 41 and 42 days, feed intake from 35 to 41 days, feed conversion ratio from 35 to 41 days and, body weight gain from 35 to 41 days of age. Results: We identified 23,214 autosomal CNVs, merged into 5042 distinct CNV regions (CNVRs), covering 12.84% of the chicken autosomal genome. One significant CNV segment was associated with BWG on GGA3 (q-value = 0.00443); one significant CNV segment was associated with BW35 (q-value = 0.00571), BW41 (q-value = 0.00180) and BW42 (q-value = 0.00130) on GGA3, and one significant CNV segment was associated with BW on GGA5 (q-value = 0.00432). All significant CNV segments were verified by qPCR, and a validation rate of 92.59% was observed. These CNV segments are located nearby genes, such as KCNJ11, MyoD1 and SOX6, known to underlie growth and development. Moreover, gene-set analyses revealed terms linked with muscle physiology, cellular p... Mostrar Tudo |
Palavras-Chave: |
CNVs; Copy number variations; Desempenho zootécnico; GWAS; QPCR; QTLs. |
Thesagro: |
Gallus Domesticus; Genética Animal; Performance. |
Thesaurus Nal: |
Animal genetics; Animal performance; Gallus gallus; Genome-wide association study; Quantitative polymerase chain reaction; Quantitative trait loci. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/224781/1/final9547.pdf
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Marc: |
LEADER 03101naa a2200433 a 4500 001 2133197 005 2021-08-03 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1186/s12864-021-07676-1$2DOI 100 1 $aFERNANDES, A. C. 245 $aGenome-wide detection of CNVs and their association with performance traits in broilers.$h[electronic resource] 260 $c2021 520 $aAbstract Background: Copy number variations (CNVs) are a major type of structural genomic variants that underlie genetic architecture and phenotypic variation of complex traits, not only in humans, but also in livestock animals. We identified CNVs along the chicken genome and analyzed their association with performance traits. Genome-wide CNVs were inferred from Affymetrix® high density SNP-chip data for a broiler population. CNVs were concatenated into segments and association analyses were performed with linear mixed models considering a genomic relationship matrix, for birth weight, body weight at 21, 35, 41 and 42 days, feed intake from 35 to 41 days, feed conversion ratio from 35 to 41 days and, body weight gain from 35 to 41 days of age. Results: We identified 23,214 autosomal CNVs, merged into 5042 distinct CNV regions (CNVRs), covering 12.84% of the chicken autosomal genome. One significant CNV segment was associated with BWG on GGA3 (q-value = 0.00443); one significant CNV segment was associated with BW35 (q-value = 0.00571), BW41 (q-value = 0.00180) and BW42 (q-value = 0.00130) on GGA3, and one significant CNV segment was associated with BW on GGA5 (q-value = 0.00432). All significant CNV segments were verified by qPCR, and a validation rate of 92.59% was observed. These CNV segments are located nearby genes, such as KCNJ11, MyoD1 and SOX6, known to underlie growth and development. Moreover, gene-set analyses revealed terms linked with muscle physiology, cellular processes regulation and potassium channels. Conclusions: Overall, this CNV-based GWAS study unravels potential candidate genes that may regulate performance traits in chickens. Our findings provide a foundation for future functional studies on the role of specific genes in regulating performance in chickens. Keywords: GWAS, Performance, CNVs, QTLs, qPCR 650 $aAnimal genetics 650 $aAnimal performance 650 $aGallus gallus 650 $aGenome-wide association study 650 $aQuantitative polymerase chain reaction 650 $aQuantitative trait loci 650 $aGallus Domesticus 650 $aGenética Animal 650 $aPerformance 653 $aCNVs 653 $aCopy number variations 653 $aDesempenho zootécnico 653 $aGWAS 653 $aQPCR 653 $aQTLs 700 1 $aSILVA, V. H. da 700 1 $aGOES, C. P. 700 1 $aMOREIRA, G. C. M. 700 1 $aGODOY, T. F. 700 1 $aIBELLI, A. M. G. 700 1 $aPEIXOTO, J. de O. 700 1 $aCANTAO, M. E. 700 1 $aLEDUR, M. C. 700 1 $aREZENDE, F. M. de 700 1 $aCOUTINHO, L. L. 773 $tBMC Genomics$gv. 22, n. 354, 2021.
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Embrapa Suínos e Aves (CNPSA) |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
26/02/2015 |
Data da última atualização: |
17/05/2022 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
JERÔNIMO JÚNIOR, J. A.; SALES, M. R. B.; OLIVEIRA, E. L. de; SILVA, A. K. M.; SOUZA, H. A. de. |
Afiliação: |
EDUARDO LUIZ DE OLIVEIRA, CNPC; HENRIQUE ANTUNES DE SOUZA, CNPC. |
Título: |
Avaliação microbiológica do lixiviado do processo de compostagem de resíduos da produção e abate de pequenos ruminantes. |
Ano de publicação: |
2014 |
Fonte/Imprenta: |
In: ENCONTRO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA CAPRINOS E OVINOS, 3., 2014, Sobral. Anais... Sobral: Embrapa Caprinos e Ovinos, 2014. p. 30. |
Idioma: |
Português |
Palavras-Chave: |
Residues. |
Thesagro: |
Abate; Caprino; Coliforme; Compostagem; Ovino; Resíduo. |
Thesaurus NAL: |
Coliform bacteria; Composting; Goats; Sheep. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/118786/1/cnpc-2014-Avaliacao-microbiologica-do.pdf
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Marc: |
LEADER 00904nam a2200277 a 4500 001 2009947 005 2022-05-17 008 2014 bl uuuu u00u1 u #d 100 1 $aJERÔNIMO JÚNIOR, J. A. 245 $aAvaliação microbiológica do lixiviado do processo de compostagem de resíduos da produção e abate de pequenos ruminantes.$h[electronic resource] 260 $aIn: ENCONTRO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA CAPRINOS E OVINOS, 3., 2014, Sobral. Anais... Sobral: Embrapa Caprinos e Ovinos, 2014. p. 30.$c2014 650 $aColiform bacteria 650 $aComposting 650 $aGoats 650 $aSheep 650 $aAbate 650 $aCaprino 650 $aColiforme 650 $aCompostagem 650 $aOvino 650 $aResíduo 653 $aResidues 700 1 $aSALES, M. R. B. 700 1 $aOLIVEIRA, E. L. de 700 1 $aSILVA, A. K. M. 700 1 $aSOUZA, H. A. de
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