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Registro Completo |
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Biblioteca(s): |
Embrapa Cerrados. |
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Data corrente: |
19/01/2004 |
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Data da última atualização: |
07/08/2017 |
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Autoria: |
REIS JUNIOR, F. B. dos; SILVA, M. F. da; TEIXEIRA, K. R. dos S.; URQUIAGA, S.; REIS, V. M. |
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Título: |
Utilizacao do sistema BIOLOG para avaliacao da diversidade intraespecifica de isolados de Azospirillum amazonense oriundos da associacao de diferentes especies de brachiaria. |
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Ano de publicação: |
2002 |
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Fonte/Imprenta: |
Planaltina: Embrapa Cerrados, 2002. |
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Descrição Física: |
1 folder. |
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Idioma: |
Português |
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Thesagro: |
Bactéria; Fixação de Nitrogênio; Microbiologia do Solo; Pastagem. |
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Thesaurus Nal: |
Azospirillum amazonense; microbiology; nitrogen fixation; pastures; soil. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/CPAC-2009/24156/1/p2002_41.pdf
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Marc: |
LEADER 00836nam a2200265 a 4500
001 1567463
005 2017-08-07
008 2002 bl uuuu u0uu1 u #d
100 1 $aREIS JUNIOR, F. B. dos
245 $aUtilizacao do sistema BIOLOG para avaliacao da diversidade intraespecifica de isolados de Azospirillum amazonense oriundos da associacao de diferentes especies de brachiaria.
260 $aPlanaltina: Embrapa Cerrados$c2002
300 $c1 folder.
650 $aAzospirillum amazonense
650 $amicrobiology
650 $anitrogen fixation
650 $apastures
650 $asoil
650 $aBactéria
650 $aFixação de Nitrogênio
650 $aMicrobiologia do Solo
650 $aPastagem
700 1 $aSILVA, M. F. da
700 1 $aTEIXEIRA, K. R. dos S.
700 1 $aURQUIAGA, S.
700 1 $aREIS, V. M.
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Registro original: |
Embrapa Cerrados (CPAC) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Cerrados; Embrapa Pecuária Sudeste. |
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Data corrente: |
25/08/2017 |
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Data da última atualização: |
25/08/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
CASTRO, L. M. de; ROSA, G. J. de M.; LOPES, F. B.; REGITANO, L. C. de A.; ROSA, A. J. de M.; MAGNABOSCO, C. de U. |
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Afiliação: |
Letícia Mendes de Castro, UFG; Guilherme Jordão de Magalhães Rosa, University of Wisconsin; Fernando Brito Lopes, Bolsista/Embrapa Cerrados; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; ARTUR JORDAO DE MAGALHAES ROSA, CPAC; CLAUDIO DE ULHOA MAGNABOSCO, CPAC. |
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Título: |
Genomewide association mapping and pathway analysis of meat tenderness in Polled Nellore cattle. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of Animal Science, v. 95, n. 5, p. 1945-1956, 2017. |
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DOI: |
10.2527/jas.2016.1348 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Brazil is one of the world?s largest beef exporters, although the product has a low price due to quality issues. The meat exported by Brazil is considered medium and low quality by international buyers, mainly due to lack of tenderness. The predominant Zebu breeds (80% Nellore) are known for producing tougher beef than taurine breeds. Nonetheless, some studies have shown that there is substantial genetic variability for tenderness within the Nellore breed, although it is a difficult trait to improve by conventional selection methods. Therefore, the aim of this study was to perform a genomewide association study (GWAS) and a gene set enrichment analysis to identify genomic regions and biologically relevant pathways associated with meat tenderness in Polled Nellore cattle. Data consisted of Warner?Bratzler shear force values of LM from 427 Polled Nellore animals divided into 3 experimental slaughters (years 2005, 2008, and 2010). The animals were genotyped with either the Illumina BovineHD BeadChip (777k, on 61 samples) or the GGP Indicus HD chip (77k, on 366 samples). Single nucleotide polymorphisms were excluded when the call rate was <90%, the Hardy?Weinberg proportions P-value was <1% (Fisher exact test, Bonferroni adjusted), and the minor allele frequency was <1%. Imputation from the GGP Indicus HD chip to the Illumina BovineHD BeadChip was performed using the FImput program. Genomewide association analysis was performed using the Efficient Mixed Model Association eXpedited (EMMAx) and the population parameters previously determined (P3D) methods. The GWAS was complemented with a gene set enrichment analysis performed using the FatiGO procedure. Significant markers (P < 0.0001) explaining a larger proportion of variation than other significant SNPs were located on chromosomes 3, 13, 17, 20, 21, and 25, indicating QTL associated with meat tenderness throughout the genome. Additionally, gene set analysis identified 22 Gene Ontology functional terms and 2 InterPro entries that showed significant enrichment of genes associated with tenderness. The functional categories included protein tyrosine and serine/threonine kinase activity, calcium ion binding, lipid metabolic process, and growth factors, among others. These results help to elucidate the genetic architecture and metabolic pathways underlying this trait, which is of extreme economic and social importance to Brazil, because Nellore is the dominant beef cattle breed in the country. MenosAbstract: Brazil is one of the world?s largest beef exporters, although the product has a low price due to quality issues. The meat exported by Brazil is considered medium and low quality by international buyers, mainly due to lack of tenderness. The predominant Zebu breeds (80% Nellore) are known for producing tougher beef than taurine breeds. Nonetheless, some studies have shown that there is substantial genetic variability for tenderness within the Nellore breed, although it is a difficult trait to improve by conventional selection methods. Therefore, the aim of this study was to perform a genomewide association study (GWAS) and a gene set enrichment analysis to identify genomic regions and biologically relevant pathways associated with meat tenderness in Polled Nellore cattle. Data consisted of Warner?Bratzler shear force values of LM from 427 Polled Nellore animals divided into 3 experimental slaughters (years 2005, 2008, and 2010). The animals were genotyped with either the Illumina BovineHD BeadChip (777k, on 61 samples) or the GGP Indicus HD chip (77k, on 366 samples). Single nucleotide polymorphisms were excluded when the call rate was <90%, the Hardy?Weinberg proportions P-value was <1% (Fisher exact test, Bonferroni adjusted), and the minor allele frequency was <1%. Imputation from the GGP Indicus HD chip to the Illumina BovineHD BeadChip was performed using the FImput program. Genomewide association analysis was performed using the Efficient Mixed Model Associati... Mostrar Tudo |
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Palavras-Chave: |
Estudo de associação de genoma (GWAS); Gene ontology; Metabolic pathways; Parâmetro metabólico; Ternura da Carne. |
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Thesagro: |
Bos Indicus; Carne; Gado Nelore; Parâmetro Genético. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 03425naa a2200301 a 4500
001 2074456
005 2017-08-25
008 2017 bl uuuu u00u1 u #d
024 7 $a10.2527/jas.2016.1348$2DOI
100 1 $aCASTRO, L. M. de
245 $aGenomewide association mapping and pathway analysis of meat tenderness in Polled Nellore cattle.$h[electronic resource]
260 $c2017
520 $aAbstract: Brazil is one of the world?s largest beef exporters, although the product has a low price due to quality issues. The meat exported by Brazil is considered medium and low quality by international buyers, mainly due to lack of tenderness. The predominant Zebu breeds (80% Nellore) are known for producing tougher beef than taurine breeds. Nonetheless, some studies have shown that there is substantial genetic variability for tenderness within the Nellore breed, although it is a difficult trait to improve by conventional selection methods. Therefore, the aim of this study was to perform a genomewide association study (GWAS) and a gene set enrichment analysis to identify genomic regions and biologically relevant pathways associated with meat tenderness in Polled Nellore cattle. Data consisted of Warner?Bratzler shear force values of LM from 427 Polled Nellore animals divided into 3 experimental slaughters (years 2005, 2008, and 2010). The animals were genotyped with either the Illumina BovineHD BeadChip (777k, on 61 samples) or the GGP Indicus HD chip (77k, on 366 samples). Single nucleotide polymorphisms were excluded when the call rate was <90%, the Hardy?Weinberg proportions P-value was <1% (Fisher exact test, Bonferroni adjusted), and the minor allele frequency was <1%. Imputation from the GGP Indicus HD chip to the Illumina BovineHD BeadChip was performed using the FImput program. Genomewide association analysis was performed using the Efficient Mixed Model Association eXpedited (EMMAx) and the population parameters previously determined (P3D) methods. The GWAS was complemented with a gene set enrichment analysis performed using the FatiGO procedure. Significant markers (P < 0.0001) explaining a larger proportion of variation than other significant SNPs were located on chromosomes 3, 13, 17, 20, 21, and 25, indicating QTL associated with meat tenderness throughout the genome. Additionally, gene set analysis identified 22 Gene Ontology functional terms and 2 InterPro entries that showed significant enrichment of genes associated with tenderness. The functional categories included protein tyrosine and serine/threonine kinase activity, calcium ion binding, lipid metabolic process, and growth factors, among others. These results help to elucidate the genetic architecture and metabolic pathways underlying this trait, which is of extreme economic and social importance to Brazil, because Nellore is the dominant beef cattle breed in the country.
650 $aBos Indicus
650 $aCarne
650 $aGado Nelore
650 $aParâmetro Genético
653 $aEstudo de associação de genoma (GWAS)
653 $aGene ontology
653 $aMetabolic pathways
653 $aParâmetro metabólico
653 $aTernura da Carne
700 1 $aROSA, G. J. de M.
700 1 $aLOPES, F. B.
700 1 $aREGITANO, L. C. de A.
700 1 $aROSA, A. J. de M.
700 1 $aMAGNABOSCO, C. de U.
773 $tJournal of Animal Science$gv. 95, n. 5, p. 1945-1956, 2017.
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