Data/hora: 11/06/2024 16:51:36

Biblioteca(s): 	Embrapa Gado de Leite; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul.	
Data corrente: 	25/03/2024	
Data da última atualização: 	25/03/2024	
Autoria: 	CARVALHO, W. A.; GASPAR, E. B.; DOMINGUES, R.; REGITANO, L. C. de A.; CARDOSO, F. F.	
Afiliação: 	WANESSA ARAUJO CARVALHO, CNPGL; EMANUELLE BALDO GASPAR, CNPGL; ROBERT DOMINGUES, CNPGL; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL.	
Título: 	Genetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle: a systems biology perspective.	
Ano de publicação: 	2024	
Fonte/Imprenta: 	Mammalian Genome, 2024.	
DOI: 	https://doi.org/10.1007/s00335-024-10030-x	
Idioma: 	Inglês	
Notas: 	First online.	
Conteúdo: 	Approximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle.	
Thesagro: 	Bovino; Carrapato; Doença Animal; Parasitismo; Resistência.	
Thesaurus Nal: 	Amber disease; Parasitism; Ticks.	
Categoria do assunto: 	L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
Exemplares: 	CNPGL - (26304-1) - UPC - AP - DD -  -  -  - DIS
CPPSUL - (15083-1) - UPC - AP - DD -  -  -  - DIS
CPPSE - (26361-1) - UPC - AP - DD - PROCI-2024.00019 - CAR - 2024.00068 - DIS