Data/hora: 14/06/2024 16:58:32

Biblioteca(s): 	Ebooks.	
Data corrente: 	01/02/2013	
Data da última atualização: 	01/02/2013	
Autoria: 	ZENT, R.; POZZI, A.	
Afiliação: 	Roy Zent; Ambra Pozzi.	
Título: 	Cell-Extracellular Matrix Interactions in Cancer.	
Edição: 	1.	
Ano de publicação: 	2010	
Fonte/Imprenta: 	Springer eBooks.	
Páginas: 	XII, 314p. 22 illus., 11 illus. in color. With 1 4-page colo	
Descrição Física: 	digital.	
ISBN: 	9781441908148	
DOI: 	10.1007/978-1-4419-0814-8	
Idioma: 	Inglês	
Conteúdo: 	<P>The Extracellular Matrix—an Overview -- Integrin structure and function -- Cancer in context: Importance of the tumor microenvironment -- Basement Membrane Collagens and Cancer -- Laminins and Cancer Progression -- Fibronectins and their receptors in cancer -- Vitronectin Binding Integrins in Cancer -- The Function of SPARC in Tumor Cell Biology: SPARC as a Modulator of Cell-Extracellular Matrix Interaction -- Proteoglycans and Cancer -- Tetraspanins in Cancer -- The Role of Integrin-Linked Kinase in Cancer Development and Progression -- Focal Adhesion Kinase with the interacting proteins and signaling in cancer.</P>.<P>Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions. </P> <P>Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer. </P>	
Palavras-Chave: 	Biomedicine; Cancer Research; Cytology; Oncology; Pharmacology/Toxicology.	
Thesaurus Nal: 	cell biology; medicine; toxicology.	
Categoria do assunto: 	--	
URL: 	http://dx.doi.org/10.1007/978-1-4419-0814-8	
Registro original: 	Ebooks (Ebooks)