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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
16/02/2017 |
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Data da última atualização: |
30/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PERIPOLLI, E.; MUNARI, D. P.; SILVA, M. V. G. B.; LIMA, A. L.; IRGANG, R.; BALDI, F. |
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Afiliação: |
E. Peripolli, UNESP; D. P. MUNARI, UNESP; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; A. L. LIMA, UFSC; R. IRGANG, UFSC; F. BALDI, UNESP. |
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Título: |
Runs of homozygosity: current knowledge and applications in livestock. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Animal Genetics, v. 48, n. 3, p. 255-271, 2017. |
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DOI: |
10.1111/age.12526 |
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Idioma: |
Inglês |
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Notas: |
Publicado online em 1 dez. 2016. |
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Conteúdo: |
This review presents a broader approach to the implementation and study of runs of homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH and their practical implications. ROH are continuous homozygous segments that are common in individuals and populations. The ability of these homozygous segments to give insight into a population's genetic events makes them a useful tool that can provide information about the demographic evolution of a population over time. Furthermore, ROH provide useful information about the genetic relatedness among individuals, helping to minimize the inbreeding rate and also helping to expose deleterious variants in the genome. The frequency, size and distribution of ROH in the genome are influenced by factors such as natural and artificial selection, recombination, linkage disequilibrium, population structure, mutation rate and inbreeding level. Calculating the inbreeding coefficient from molecular information from ROH (FROH ) is more accurate for estimating autozygosity and for detecting both past and more recent inbreeding effects than are estimates from pedigree data (FPED ). The better results of FROH suggest that FROH can be used to infer information about the history and inbreeding levels of a population in the absence of genealogical information. The selection of superior animals has produced large phenotypic changes and has reshaped the ROH patterns in various regions of the genome. Additionally, selection increases homozygosity around the target locus, and deleterious variants are seen to occur more frequently in ROH regions. Studies involving ROH are increasingly common and provide valuable information about how the genome's architecture can disclose a population's genetic background. By revealing the molecular changes in populations over time, genome-wide information is crucial to understanding antecedent genome architecture and, therefore, to maintaining diversity and fitness in endangered livestock breeds. MenosThis review presents a broader approach to the implementation and study of runs of homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH and their practical implications. ROH are continuous homozygous segments that are common in individuals and populations. The ability of these homozygous segments to give insight into a population's genetic events makes them a useful tool that can provide information about the demographic evolution of a population over time. Furthermore, ROH provide useful information about the genetic relatedness among individuals, helping to minimize the inbreeding rate and also helping to expose deleterious variants in the genome. The frequency, size and distribution of ROH in the genome are influenced by factors such as natural and artificial selection, recombination, linkage disequilibrium, population structure, mutation rate and inbreeding level. Calculating the inbreeding coefficient from molecular information from ROH (FROH ) is more accurate for estimating autozygosity and for detecting both past and more recent inbreeding effects than are estimates from pedigree data (FPED ). The better results of FROH suggest that FROH can be used to infer information about the history and inbreeding levels of a population in the absence of genealogical information. The selection of superior animals has produced large phenotypic changes and has reshaped the ROH patterns in various regions of the genome. Additionally, selection in... Mostrar Tudo |
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Palavras-Chave: |
Autozygosity; Genetic diversity. |
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Thesaurus Nal: |
homozygosity; inbreeding; livestock. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
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001 2064504
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008 2017 bl uuuu u00u1 u #d
024 7 $a10.1111/age.12526$2DOI
100 1 $aPERIPOLLI, E.
245 $aRuns of homozygosity$bcurrent knowledge and applications in livestock.$h[electronic resource]
260 $c2017
500 $aPublicado online em 1 dez. 2016.
520 $aThis review presents a broader approach to the implementation and study of runs of homozygosity (ROH) in animal populations, focusing on identifying and characterizing ROH and their practical implications. ROH are continuous homozygous segments that are common in individuals and populations. The ability of these homozygous segments to give insight into a population's genetic events makes them a useful tool that can provide information about the demographic evolution of a population over time. Furthermore, ROH provide useful information about the genetic relatedness among individuals, helping to minimize the inbreeding rate and also helping to expose deleterious variants in the genome. The frequency, size and distribution of ROH in the genome are influenced by factors such as natural and artificial selection, recombination, linkage disequilibrium, population structure, mutation rate and inbreeding level. Calculating the inbreeding coefficient from molecular information from ROH (FROH ) is more accurate for estimating autozygosity and for detecting both past and more recent inbreeding effects than are estimates from pedigree data (FPED ). The better results of FROH suggest that FROH can be used to infer information about the history and inbreeding levels of a population in the absence of genealogical information. The selection of superior animals has produced large phenotypic changes and has reshaped the ROH patterns in various regions of the genome. Additionally, selection increases homozygosity around the target locus, and deleterious variants are seen to occur more frequently in ROH regions. Studies involving ROH are increasingly common and provide valuable information about how the genome's architecture can disclose a population's genetic background. By revealing the molecular changes in populations over time, genome-wide information is crucial to understanding antecedent genome architecture and, therefore, to maintaining diversity and fitness in endangered livestock breeds.
650 $ahomozygosity
650 $ainbreeding
650 $alivestock
653 $aAutozygosity
653 $aGenetic diversity
700 1 $aMUNARI, D. P.
700 1 $aSILVA, M. V. G. B.
700 1 $aLIMA, A. L.
700 1 $aIRGANG, R.
700 1 $aBALDI, F.
773 $tAnimal Genetics$gv. 48, n. 3, p. 255-271, 2017.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
11/02/2017 |
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Data da última atualização: |
08/04/2024 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
AMARAL, D. L. A. S. Do; ALMEIDA, L. B. F. De; ZANETTE, R. De S. S.; BRANDAO, H. de M.; MARANDUBA, C. M. Da C.; MUNK, M. |
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Afiliação: |
DANIELLE LUCIANA AURORA SOARES DO AMARAL, UFJF; LEONARA BEATRIZ FAYER DE ALMEIDA, UFJF; RAFAELLA DE SOUZA SALOMÃO ZANETTE, UFJF; HUMBERTO DE MELLO BRANDAO, CNPGL; CARLOS MAGNO DA COSTA MARANDUBA, UFJF; MICHELE MUNK, UFJF. |
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Título: |
Produção de hidrogéis de alginato com nanopartículas de titanato de bário para uso na engenharia de tecido ósseo |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
In: SIMPÓSIO NACIONAL DE NANOBIOTECNOLOGIA, 1.; WORKSHOP DE NANOBIOTECNOLOGIA DA UFMG, 2., 2016, Belo Horizonte. Avanços e aplicações: anais. Belo Horizonte: Universidade Federal de Minas Gerais, 2016. |
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Páginas: |
p. 33-34. |
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Idioma: |
Português |
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Palavras-Chave: |
Alginato; Gelificação; Nanomateriais. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1063664/1/Producao-de-hidrogeis-de-alginato.pdf
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Marc: |
LEADER 00823nam a2200205 a 4500
001 2063664
005 2024-04-08
008 2016 bl uuuu u00u1 u #d
100 1 $aAMARAL, D. L. A. S. Do
245 $aProdução de hidrogéis de alginato com nanopartículas de titanato de bário para uso na engenharia de tecido ósseo$h[electronic resource]
260 $aIn: SIMPÓSIO NACIONAL DE NANOBIOTECNOLOGIA, 1.; WORKSHOP DE NANOBIOTECNOLOGIA DA UFMG, 2., 2016, Belo Horizonte. Avanços e aplicações: anais. Belo Horizonte: Universidade Federal de Minas Gerais$c2016
300 $ap. 33-34.
653 $aAlginato
653 $aGelificação
653 $aNanomateriais
700 1 $aALMEIDA, L. B. F. De
700 1 $aZANETTE, R. De S. S.
700 1 $aBRANDAO, H. de M.
700 1 $aMARANDUBA, C. M. Da C.
700 1 $aMUNK, M.
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