|
|
| Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Amazônia Oriental. |
Data corrente: |
20/12/2018 |
Data da última atualização: |
09/01/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
BARBOSA, M. M. C.; VICENTINI, F. A.; CASTRO-GHIZONI, C. V.; LAMEIRA, O. A.; SÁ-NAKANISHI, A. B.; BRACHT, L.; PERALTA, R. M.; NATALI, M. R. M.; BRACHT, A.; COMAR, J. F. |
Afiliação: |
Maiara Morseli Coelho Barbosa, UNIVERSIDADE DE MARINGÁ; Fernando Augusto Vicentini, UNIVERSIDADE DE MARINGÁ; Cristiane Vizioli Castro-Ghizoni, UNIVERSIDADE DE MARINGÁ; OSMAR ALVES LAMEIRA, CPATU; Anacharis Babeto Sá-Nakanishi, UNIVERSIDADE DE MARINGÁ; Lívia Bracht, UNIVERSIDADE DE MARINGÁ; Rosane Marina Peralta, UNIVERSIDADE DE MARINGÁ; Maria Raquel Marçal Natali, UNIVERSIDADE DE MARINGÁ; Adelar Bracht, UNIVERSIDADE DE MARINGÁ; Jurandir Fernando Comar, UNIVERSIDADE DE MARINGÁ. |
Título: |
Copaiba oil decreases oxidative stress and inflammation but not colon damage in rats with TNBS-induced colitis. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
Endocrine, Metabolic & Immune Disorders. Drug Targets, v. 18 , n. 3 , p. 268-280, 2018. |
DOI: |
10.2174/1871530318666180215102029 |
Idioma: |
Inglês |
Conteúdo: |
Background: TNBS-induced colitis is an experimental immunopathology in rats that shares many features with human inflammatory bowel diseases. Copaiba oleoresin is extracted from plants of the genus Copaifera and is shown to reduce inflammation. Objective: The aim of this study was to investigate the action of copaiba oil (C. reticulata Ducke) on inflammation and oxidative status in the distal colon of colitic rats. Methods: Acute and subchronic colitis were induced in Wistar rats by an intracolonic enema with 2,4,6-trinitrobenzenesulfonic acid (TNBS). The colonic morphology was assessed by histological analysis and the oxidative stress parameters were measured in the intestinal homogenate. The liver damage markers were measured in the plasma. Control and colitic rats were orally treated either with one single dose (acute colitis) of copaiba oil (1.15 g Kg-1) or once a day during seven days (subchronic colitis). Results: The intestinal morphology was severely modified by acute and subchronic colitis, as indicated by the intramural infiltration of polymorphonuclear cells and the increased thickness of all colon layers. The levels of TBARS, protein carbonyl groups and reactive oxygen species (ROS) were increased in the intestine of colitic rats. Copaiba oil did not attenuate the inflammatory damage in acute and subchronic colitis, but it decreased the activity of myeloperoxidase, leukocyte infiltration and oxidative stress in the colon. The level of plasma bilirubin and the activity of alkaline phosphatase were both increased in treated healthy and colitic rats. Conclusion: Copaiba oil decreased oxidative stress and inflammation but did not prevent intestinal damage in the colon of colitic rats. The alterations of plasma markers of hepatic damage caused by the oil seem to be associated to its harmful action on the liver. MenosBackground: TNBS-induced colitis is an experimental immunopathology in rats that shares many features with human inflammatory bowel diseases. Copaiba oleoresin is extracted from plants of the genus Copaifera and is shown to reduce inflammation. Objective: The aim of this study was to investigate the action of copaiba oil (C. reticulata Ducke) on inflammation and oxidative status in the distal colon of colitic rats. Methods: Acute and subchronic colitis were induced in Wistar rats by an intracolonic enema with 2,4,6-trinitrobenzenesulfonic acid (TNBS). The colonic morphology was assessed by histological analysis and the oxidative stress parameters were measured in the intestinal homogenate. The liver damage markers were measured in the plasma. Control and colitic rats were orally treated either with one single dose (acute colitis) of copaiba oil (1.15 g Kg-1) or once a day during seven days (subchronic colitis). Results: The intestinal morphology was severely modified by acute and subchronic colitis, as indicated by the intramural infiltration of polymorphonuclear cells and the increased thickness of all colon layers. The levels of TBARS, protein carbonyl groups and reactive oxygen species (ROS) were increased in the intestine of colitic rats. Copaiba oil did not attenuate the inflammatory damage in acute and subchronic colitis, but it decreased the activity of myeloperoxidase, leukocyte infiltration and oxidative stress in the colon. The level of plasma bilirubin and the act... Mostrar Tudo |
Palavras-Chave: |
Copaifera reticulata; Doença inflamatória intestinal. |
Thesagro: |
Copaíba; Óleo. |
Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
Marc: |
LEADER 02772naa a2200289 a 4500 001 2102155 005 2019-01-09 008 2018 bl uuuu u00u1 u #d 024 7 $a10.2174/1871530318666180215102029$2DOI 100 1 $aBARBOSA, M. M. C. 245 $aCopaiba oil decreases oxidative stress and inflammation but not colon damage in rats with TNBS-induced colitis.$h[electronic resource] 260 $c2018 520 $aBackground: TNBS-induced colitis is an experimental immunopathology in rats that shares many features with human inflammatory bowel diseases. Copaiba oleoresin is extracted from plants of the genus Copaifera and is shown to reduce inflammation. Objective: The aim of this study was to investigate the action of copaiba oil (C. reticulata Ducke) on inflammation and oxidative status in the distal colon of colitic rats. Methods: Acute and subchronic colitis were induced in Wistar rats by an intracolonic enema with 2,4,6-trinitrobenzenesulfonic acid (TNBS). The colonic morphology was assessed by histological analysis and the oxidative stress parameters were measured in the intestinal homogenate. The liver damage markers were measured in the plasma. Control and colitic rats were orally treated either with one single dose (acute colitis) of copaiba oil (1.15 g Kg-1) or once a day during seven days (subchronic colitis). Results: The intestinal morphology was severely modified by acute and subchronic colitis, as indicated by the intramural infiltration of polymorphonuclear cells and the increased thickness of all colon layers. The levels of TBARS, protein carbonyl groups and reactive oxygen species (ROS) were increased in the intestine of colitic rats. Copaiba oil did not attenuate the inflammatory damage in acute and subchronic colitis, but it decreased the activity of myeloperoxidase, leukocyte infiltration and oxidative stress in the colon. The level of plasma bilirubin and the activity of alkaline phosphatase were both increased in treated healthy and colitic rats. Conclusion: Copaiba oil decreased oxidative stress and inflammation but did not prevent intestinal damage in the colon of colitic rats. The alterations of plasma markers of hepatic damage caused by the oil seem to be associated to its harmful action on the liver. 650 $aCopaíba 650 $aÓleo 653 $aCopaifera reticulata 653 $aDoença inflamatória intestinal 700 1 $aVICENTINI, F. A. 700 1 $aCASTRO-GHIZONI, C. V. 700 1 $aLAMEIRA, O. A. 700 1 $aSÁ-NAKANISHI, A. B. 700 1 $aBRACHT, L. 700 1 $aPERALTA, R. M. 700 1 $aNATALI, M. R. M. 700 1 $aBRACHT, A. 700 1 $aCOMAR, J. F. 773 $tEndocrine, Metabolic & Immune Disorders. Drug Targets$gv. 18 , n. 3 , p. 268-280, 2018.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Amazônia Oriental (CPATU) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
Registro Completo
Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
07/12/2016 |
Data da última atualização: |
06/02/2024 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
WELLER, M. M. D. C. A.; FORTES, M. R. S.; MARCONDES, M. I.; ROTTA, P. P.; GIONBELI, T. R. S.; VALADARES FILHO, S. C.; CAMPOS, M. M.; SILVA, F. F.; SILVA, W.; MOORE, S.; GUIMARÃES, S. E. F. |
Afiliação: |
M. M. D. C. A. Weller, University of Queensland, Brisbane; M. R. S. Fortes, University of Queensland, Brisbane; M. I. Marcondes, UFV; P. P. Rotta, UFV; T. R. S. Gionbeli, UFV; S. C. Valadares Filho, UFV; MARIANA MAGALHAES CAMPOS, CNPGL; F.F. Silva, UFV; W. Silva, UFV; S. Moore, University of Queensland, Brisbane; S. E. F. Guimarães, UFV. |
Título: |
Effect of maternal nutrition and days of gestation on pituitary gland and gonadal gene expression in cattle. |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
Journal of Dairy Science, v. 99, n. 4, p. 3056-3071, 2016. |
DOI: |
https://doi.org/10.3168/jds.2015-9673 |
Idioma: |
Inglês |
Conteúdo: |
This study investigated effects of maternal overnutrition on gonadal development and pituitary-gonadal gene expression in cattle fetuses at mid- and late-gestation. Twenty-seven multiparous dry cows were fed either high (ad libitum, H) or moderate (M) intake of the same diet. Twelve cows from H (n=6) and M (n=6) intake carrying females fetuses were euthanized at 199 and 268d of gestation (DG; n=3 for H or M on each DG). Fifteen cows from H (n=6) and M intake (n=9) carrying male fetuses were euthanized at 139, 199, and 241 DG (n=2 for H and n=3 for M on each DG). Fetal gonads and pituitary gland were sampled for gene expression and histological analyses. Sex-specific responses to maternal intake were observed. Primordial and total follicle numbers were lower in fetal ovaries from H than in M intake cows. These results were the reverse for preantral and antral follicles. Volumetric proportion and diameter of seminiferous cord were lower in fetal testis of H than M intake cows. The expression level of FSHB was greater in pituitary gland of the female fetus from H compared with M intake cows, irrespective of DG, whereas LHB gene expression did not differ. In males, FSHB and LHB gene expression levels were similar between maternal intake groups. Fetal ovarian expression of P450 aromatase, StAR, BMPR2, TGFBR1, GDF9, FSHR, Bax, and CASP3 genes were higher in H than in M intake cows, irrespective of DG. Fetal testicular expression of StAR, HSD17B3, IGF1, IGF2, and IGF1R genes was higher in M than in H intake cows. The differences in gene expression for steroidogenesis, folliculogenesis, and apoptosis may explain the distinct pattern of follicular growth between offspring of M and H intake cows. By contrast, the lower volumetric proportion, diameter, and length of seminiferous cord may relate to decreased gene expression in fetal testis from H intake cows. In conclusion, maternal H intake seems to affect fetal ovarian follicular growth and number of follicles, which may affect the size of ovarian reserve in their offspring. In male fetus, maternal H intake seems to disturb testicular development and may have implications on sperm production. The underlying mechanism of differential gene expression and the effect on offspring reproductive potential should be the focus of further research, especially considering larger sample size, reducing the chance for type I errors. MenosThis study investigated effects of maternal overnutrition on gonadal development and pituitary-gonadal gene expression in cattle fetuses at mid- and late-gestation. Twenty-seven multiparous dry cows were fed either high (ad libitum, H) or moderate (M) intake of the same diet. Twelve cows from H (n=6) and M (n=6) intake carrying females fetuses were euthanized at 199 and 268d of gestation (DG; n=3 for H or M on each DG). Fifteen cows from H (n=6) and M intake (n=9) carrying male fetuses were euthanized at 139, 199, and 241 DG (n=2 for H and n=3 for M on each DG). Fetal gonads and pituitary gland were sampled for gene expression and histological analyses. Sex-specific responses to maternal intake were observed. Primordial and total follicle numbers were lower in fetal ovaries from H than in M intake cows. These results were the reverse for preantral and antral follicles. Volumetric proportion and diameter of seminiferous cord were lower in fetal testis of H than M intake cows. The expression level of FSHB was greater in pituitary gland of the female fetus from H compared with M intake cows, irrespective of DG, whereas LHB gene expression did not differ. In males, FSHB and LHB gene expression levels were similar between maternal intake groups. Fetal ovarian expression of P450 aromatase, StAR, BMPR2, TGFBR1, GDF9, FSHR, Bax, and CASP3 genes were higher in H than in M intake cows, irrespective of DG. Fetal testicular expression of StAR, HSD17B3, IGF1, IGF2, and IGF1R genes was hi... Mostrar Tudo |
Palavras-Chave: |
Bovine species; Bovines; Overnutrition; Real-time PCR. |
Thesaurus NAL: |
Animal reproduction; fetal development; reproduction. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/151424/1/Cnpgl-2016-JDairySci-Effect-of-maternal.pdf
|
Marc: |
LEADER 03413naa a2200337 a 4500 001 2058195 005 2024-02-06 008 2016 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.3168/jds.2015-9673$2DOI 100 1 $aWELLER, M. M. D. C. A. 245 $aEffect of maternal nutrition and days of gestation on pituitary gland and gonadal gene expression in cattle.$h[electronic resource] 260 $c2016 520 $aThis study investigated effects of maternal overnutrition on gonadal development and pituitary-gonadal gene expression in cattle fetuses at mid- and late-gestation. Twenty-seven multiparous dry cows were fed either high (ad libitum, H) or moderate (M) intake of the same diet. Twelve cows from H (n=6) and M (n=6) intake carrying females fetuses were euthanized at 199 and 268d of gestation (DG; n=3 for H or M on each DG). Fifteen cows from H (n=6) and M intake (n=9) carrying male fetuses were euthanized at 139, 199, and 241 DG (n=2 for H and n=3 for M on each DG). Fetal gonads and pituitary gland were sampled for gene expression and histological analyses. Sex-specific responses to maternal intake were observed. Primordial and total follicle numbers were lower in fetal ovaries from H than in M intake cows. These results were the reverse for preantral and antral follicles. Volumetric proportion and diameter of seminiferous cord were lower in fetal testis of H than M intake cows. The expression level of FSHB was greater in pituitary gland of the female fetus from H compared with M intake cows, irrespective of DG, whereas LHB gene expression did not differ. In males, FSHB and LHB gene expression levels were similar between maternal intake groups. Fetal ovarian expression of P450 aromatase, StAR, BMPR2, TGFBR1, GDF9, FSHR, Bax, and CASP3 genes were higher in H than in M intake cows, irrespective of DG. Fetal testicular expression of StAR, HSD17B3, IGF1, IGF2, and IGF1R genes was higher in M than in H intake cows. The differences in gene expression for steroidogenesis, folliculogenesis, and apoptosis may explain the distinct pattern of follicular growth between offspring of M and H intake cows. By contrast, the lower volumetric proportion, diameter, and length of seminiferous cord may relate to decreased gene expression in fetal testis from H intake cows. In conclusion, maternal H intake seems to affect fetal ovarian follicular growth and number of follicles, which may affect the size of ovarian reserve in their offspring. In male fetus, maternal H intake seems to disturb testicular development and may have implications on sperm production. The underlying mechanism of differential gene expression and the effect on offspring reproductive potential should be the focus of further research, especially considering larger sample size, reducing the chance for type I errors. 650 $aAnimal reproduction 650 $afetal development 650 $areproduction 653 $aBovine species 653 $aBovines 653 $aOvernutrition 653 $aReal-time PCR 700 1 $aFORTES, M. R. S. 700 1 $aMARCONDES, M. I. 700 1 $aROTTA, P. P. 700 1 $aGIONBELI, T. R. S. 700 1 $aVALADARES FILHO, S. C. 700 1 $aCAMPOS, M. M. 700 1 $aSILVA, F. F. 700 1 $aSILVA, W. 700 1 $aMOORE, S. 700 1 $aGUIMARÃES, S. E. F. 773 $tJournal of Dairy Science$gv. 99, n. 4, p. 3056-3071, 2016.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Gado de Leite (CNPGL) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
Expressão de busca inválida. Verifique!!! |
|
|