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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental; Embrapa Roraima. |
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Data corrente: |
25/07/2017 |
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Data da última atualização: |
25/07/2017 |
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Tipo da produção científica: |
Boletim de Pesquisa e Desenvolvimento |
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Autoria: |
VILARINHO, A. A.; PEDROZO, C. A.; MATTIONI, J. A. M.; FONTES, J. R. A.; BASTOS, E. |
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Afiliação: |
ALOISIO ALCANTARA VILARINHO, CPAF-RR; CASSIA ANGELA PEDROZO, CPAF-RR; JOSE ALBERTO MARTELL MATTIONI, CPAF-RR. |
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Título: |
Interferência de Plantas Daninhas na Produtividade de Feijão-Caupi de Porte Ereto. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Boa Vista, RR: Embrapa Roraima, 2014. |
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Série: |
(Embrapa Roraima. Boletim de Pesquisa e Desenvolvimento, 39). |
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Idioma: |
Português |
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Thesagro: |
Vigna Unguiculata. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/162087/1/N-39-BOL-171-corrigido.pdf
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Marc: |
LEADER 00570nam a2200169 a 4500
001 2073162
005 2017-07-25
008 2014 bl uuuu u0uu1 u #d
100 1 $aVILARINHO, A. A.
245 $aInterferência de Plantas Daninhas na Produtividade de Feijão-Caupi de Porte Ereto.$h[electronic resource]
260 $aBoa Vista, RR: Embrapa Roraima$c2014
490 $a(Embrapa Roraima. Boletim de Pesquisa e Desenvolvimento, 39).
650 $aVigna Unguiculata
700 1 $aPEDROZO, C. A.
700 1 $aMATTIONI, J. A. M.
700 1 $aFONTES, J. R. A.
700 1 $aBASTOS, E.
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Registro original: |
Embrapa Roraima (CPAF-RR) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
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Data corrente: |
25/03/2024 |
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Data da última atualização: |
25/03/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 4 |
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Autoria: |
CARVALHO, W. A.; GASPAR, E. B.; DOMINGUES, R.; REGITANO, L. C. de A.; CARDOSO, F. F. |
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Afiliação: |
WANESSA ARAUJO CARVALHO, CNPGL; EMANUELLE BALDO GASPAR, CNPGL; ROBERT DOMINGUES, CNPGL; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL. |
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Título: |
Genetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle: a systems biology perspective. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Mammalian Genome, 2024. |
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DOI: |
https://doi.org/10.1007/s00335-024-10030-x |
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Idioma: |
Inglês |
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Notas: |
First online. |
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Conteúdo: |
Approximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle. MenosApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates ... Mostrar Tudo |
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Thesagro: |
Bovino; Carrapato; Doença Animal; Parasitismo; Resistência. |
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Thesaurus NAL: |
Amber disease; Parasitism; Ticks. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02431naa a2200289 a 4500
001 2163111
005 2024-03-25
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00335-024-10030-x$2DOI
100 1 $aCARVALHO, W. A.
245 $aGenetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle$ba systems biology perspective.$h[electronic resource]
260 $c2024
500 $aFirst online.
520 $aApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle.
650 $aAmber disease
650 $aParasitism
650 $aTicks
650 $aBovino
650 $aCarrapato
650 $aDoença Animal
650 $aParasitismo
650 $aResistência
700 1 $aGASPAR, E. B.
700 1 $aDOMINGUES, R.
700 1 $aREGITANO, L. C. de A.
700 1 $aCARDOSO, F. F.
773 $tMammalian Genome, 2024.
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