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Registro Completo |
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Biblioteca(s): |
Embrapa Agroenergia. |
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Data corrente: |
23/11/2022 |
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Data da última atualização: |
23/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARNEIRO, C. V. G. C.; SERRA, L. A.; PACHECO, T. F.; FERREIRA, L. M. M.; DUARTE, L. T.; FREITAS, M. N. de M.; TRICHEZ, D.; ALMEIDA, J. R. M. de. |
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Afiliação: |
CLARA VIDA GALRÃO CORRÊA CARNEIRO, UNB/CNPAE; LUANA ASSIS SERRA, UNB/CNPAE; THALYTA FRAGA PACHECO, CNPAE; LETÍCIA MARIA MALLMANN FERREIRA, UNB/CNPAE; LIVIA TEIXEIRA DUARTE BRANDAO, CNPAE; MARIANA NOGUEIRA DE MOURA FREITAS, UNB/CNPAE; DÉBORA TRICHEZ, UNB/CNPAE; JOAO RICARDO MOREIRA DE ALMEIDA, CNPAE. |
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Título: |
Advances in Komagataella phaffii Engineering for the Production of Renewable Chemicals and Proteins |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Fermentation, v. 8, n. 575, p. 2-37, 2022. |
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DOI: |
https://doi.org/10.3390/fermentation8110575 |
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Idioma: |
Inglês |
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Conteúdo: |
The need for a more sustainable society has prompted the development of bio-based processes to produce fuels, chemicals, and materials in substitution for fossil-based ones. In this context, microorganisms have been employed to convert renewable carbon sources into various products. The methylotrophic yeast Komagataella phaffii has been extensively used in the production of heterologous proteins. More recently, it has been explored as a host organism to produce various chemicals through new metabolic engineering and synthetic biology tools. This review first summarizes Komagataella taxonomy and diversity and then highlights the recent approaches in cell engineering to produce renewable chemicals and proteins. Finally, strategies to optimize and develop new fermentative processes using K. phaffii as a cell factory are presented and discussed. The yeast K. phaffii shows an outstanding performance for renewable chemicals and protein production due to its ability to metabolize different carbon sources and the availability of engineering tools. Indeed, it has been employed in producing alcohols, carboxylic acids, proteins, and other compounds using different carbon sources, including glycerol, glucose, xylose, methanol, and even CO2. |
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Palavras-Chave: |
Komagataella phaffii. |
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Thesagro: |
Biologia Vegetal. |
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Thesaurus Nal: |
Bioengineering; Pichia pastoris. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1148607/1/Advances-in-komagataella-phaffii.pdf
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Marc: |
LEADER 02069naa a2200265 a 4500
001 2148607
005 2022-11-23
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/fermentation8110575$2DOI
100 1 $aCARNEIRO, C. V. G. C.
245 $aAdvances in Komagataella phaffii Engineering for the Production of Renewable Chemicals and Proteins$h[electronic resource]
260 $c2022
520 $aThe need for a more sustainable society has prompted the development of bio-based processes to produce fuels, chemicals, and materials in substitution for fossil-based ones. In this context, microorganisms have been employed to convert renewable carbon sources into various products. The methylotrophic yeast Komagataella phaffii has been extensively used in the production of heterologous proteins. More recently, it has been explored as a host organism to produce various chemicals through new metabolic engineering and synthetic biology tools. This review first summarizes Komagataella taxonomy and diversity and then highlights the recent approaches in cell engineering to produce renewable chemicals and proteins. Finally, strategies to optimize and develop new fermentative processes using K. phaffii as a cell factory are presented and discussed. The yeast K. phaffii shows an outstanding performance for renewable chemicals and protein production due to its ability to metabolize different carbon sources and the availability of engineering tools. Indeed, it has been employed in producing alcohols, carboxylic acids, proteins, and other compounds using different carbon sources, including glycerol, glucose, xylose, methanol, and even CO2.
650 $aBioengineering
650 $aPichia pastoris
650 $aBiologia Vegetal
653 $aKomagataella phaffii
700 1 $aSERRA, L. A.
700 1 $aPACHECO, T. F.
700 1 $aFERREIRA, L. M. M.
700 1 $aDUARTE, L. T.
700 1 $aFREITAS, M. N. de M.
700 1 $aTRICHEZ, D.
700 1 $aALMEIDA, J. R. M. de
773 $tFermentation$gv. 8, n. 575, p. 2-37, 2022.
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Registro original: |
Embrapa Agroenergia (CNPAE) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
10/05/2007 |
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Data da última atualização: |
13/08/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
Internacional - A |
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Autoria: |
MORANDI, M. A. B.; MAFFIA, L. A.; MIZUBUTI, E. S. G.; ALFENAS, A. C.; BARBOSA, J. G.; CRUZ, C. D. |
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Afiliação: |
MARCELO AUGUSTO BOECHAT MORANDI, CNPMA; L. A. MAFFIA, Departamento de Fitopatologia/UFV; E. S. G. MIZUBUTI, Departamento de Fitopatologia/UFV; A. C. ALFENAS, Departamento de Fitopatologia/UFV; J. G. BARBOSA, Departamento de Fitotecnia/UFV; C. D. CRUZ, Departamento de Biologia Geral/UFV. |
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Título: |
Relationships of microclimatic variables to colonization of rose debris by Botrytis cinerea and the biocontrol agent Clonostachys rosea. |
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Ano de publicação: |
2006 |
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Fonte/Imprenta: |
Biocontrol Science and Technology, Abingdon, v. 16, n. 6, p. 619-630, jun. 2006. |
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Idioma: |
Inglês |
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Conteúdo: |
Biological control of Botrytis cinerea by Clonostachys rosea is an alternative to chemical control of rose Botrytis blight in greenhouses. Environmental conditions affect the colonization of senescing and dead tissues by both fungi. The contribution of microclimatic variables to debris colonization/sporulation by both fungi was estimated by path coefficient analysis. We monitored daily values of: maximum, average, and minimum temperatures (T-max, T-ave, and T-min), and relative humidity (RHmax, RHave, and RHmin); accumulated rainfall; vapour pressure deficit average; hours with RH > 90% (RH90); and average temperature during RH90 (T-ave90). Association of variables accumulated between the first and seventh day before sampling explained colonization/sporulation variation: R-2 = 0.81-0.86 for B. cinerea and 0.91-0.96 for C. rosea. RHmax and RH90 were the main factors that directly favoured colonization/sporulation of both fungi. Colonization/sporulation negatively correlated with RHmin, T-min, and T-ave for B. cinerea and T-min, T-ave, and T-ave90 for C. rosea. The antagonist can suppress B. cinerea colonization/sporulation on rose debris under a wide range of environmental conditions. |
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Palavras-Chave: |
Efeito; Supressividade; Variáveis microclimáticas. |
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Thesagro: |
Colonização; Condição Ambiental; Controle biológico; Epidemiologia; Esporulação; Fungo; Mofo cinzento. |
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Thesaurus NAL: |
Clonostachys rosea. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02174naa a2200313 a 4500
001 1015359
005 2015-08-13
008 2006 bl uuuu u00u1 u #d
100 1 $aMORANDI, M. A. B.
245 $aRelationships of microclimatic variables to colonization of rose debris by Botrytis cinerea and the biocontrol agent Clonostachys rosea.$h[electronic resource]
260 $c2006
520 $aBiological control of Botrytis cinerea by Clonostachys rosea is an alternative to chemical control of rose Botrytis blight in greenhouses. Environmental conditions affect the colonization of senescing and dead tissues by both fungi. The contribution of microclimatic variables to debris colonization/sporulation by both fungi was estimated by path coefficient analysis. We monitored daily values of: maximum, average, and minimum temperatures (T-max, T-ave, and T-min), and relative humidity (RHmax, RHave, and RHmin); accumulated rainfall; vapour pressure deficit average; hours with RH > 90% (RH90); and average temperature during RH90 (T-ave90). Association of variables accumulated between the first and seventh day before sampling explained colonization/sporulation variation: R-2 = 0.81-0.86 for B. cinerea and 0.91-0.96 for C. rosea. RHmax and RH90 were the main factors that directly favoured colonization/sporulation of both fungi. Colonization/sporulation negatively correlated with RHmin, T-min, and T-ave for B. cinerea and T-min, T-ave, and T-ave90 for C. rosea. The antagonist can suppress B. cinerea colonization/sporulation on rose debris under a wide range of environmental conditions.
650 $aClonostachys rosea
650 $aColonização
650 $aCondição Ambiental
650 $aControle biológico
650 $aEpidemiologia
650 $aEsporulação
650 $aFungo
650 $aMofo cinzento
653 $aEfeito
653 $aSupressividade
653 $aVariáveis microclimáticas
700 1 $aMAFFIA, L. A.
700 1 $aMIZUBUTI, E. S. G.
700 1 $aALFENAS, A. C.
700 1 $aBARBOSA, J. G.
700 1 $aCRUZ, C. D.
773 $tBiocontrol Science and Technology, Abingdon$gv. 16, n. 6, p. 619-630, jun. 2006.
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