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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
23/10/2018 |
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Data da última atualização: |
23/10/2018 |
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Autoria: |
SILVA-FILHO, J. C.; SOUSA, M. G.; FERREIRA, E. Z.; ORTIZ, E. M. G.; FRANCO, R. P.; ROSA, F. A.; CAMACHO, A. A. |
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Afiliação: |
Jorge Cardoso Silva-Filho, Departamento de Medicina Veterinária e Cirurgia/Faculdade de Ciências Agrárias e Veterinárias/Universidade Estadual Paulista - Unesp; Marlos G. Sousa, Departamento de Medicina Veterinária/Universidade Federal do Paraná - UFPR; Evandro Zacché Pereira, Departamento de Medicina Veterinária e Cirurgia/Faculdade de Ciências Agrárias e Veterinárias/Universidade Estadual Paulista - Unesp; Edna M. G. Ortiz, Departamento de Medicina Veterinária e Cirurgia/Faculdade de Ciências Agrárias e Veterinárias/Universidade Estadual Paulista - Unesp; Rodrigo P. Franco, Departamento de Medicina Veterinária e Cirurgia/Faculdade de Ciências Agrárias e Veterinárias/Universidade Estadual Paulista - Unesp; Fernando A. Rosa, Departamento de Medicina Veterinária e Cirurgia/Faculdade de Ciências Agrárias e Veterinárias/Universidade Estadual Paulista - Unesp; Aparecido Antonio Camacho, Departamento de Medicina Veterinária e Cirurgia/Faculdade de Ciências Agrárias e Veterinárias/Universidade Estadual Paulista - Unesp. |
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Título: |
Blood lactate increases with the progression of mitral valve disease in dogs. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 9, p. 1781-1786, setembro 2018 |
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Idioma: |
Inglês |
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Notas: |
Título em português: Aumento de lactato sanguíneo com progressão de valvopatia mitral em cães. |
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Conteúdo: |
In dogs with congestive heart failure, the upregulated sympathetic tone causes vasoconstriction that impairs peripheral blood supply, therefore causing the accumulation of lactate. In this prospective cross-sectional study with a longitudinal component, blood lactate was quantified in 10 healthy and 34 myxomatous mitral valve disease (MMVD) dogs to investigate its potential use as a diagnostic and prognostic biomarker. While there were no differences in lactate concentration between control animals and stages B1 (3.31±0.62mmol/L) and B2 (3.32±0.46mmol/L) dogs, significant differences were found between healthy (2.50±0.69mmol/L) and both C (3.99±0.47mmol/L) and D (6.97±1.23mmol/L) animals. When a cut-off of 3.35mmol/L was used, lactate was able to distinguish dogs with normal and remodeled hearts with a sensitivity of 78.2% and specificity of 63.6%. Also, significant correlations existed between lactate and indicators of cardiac remodeling. Finally, animals with blood lactate <3.5mmol/L carried a better prognosis when compared with dogs in which lactate was >5.0mmol/L. Our results suggest that the progression of MMVD results in accumulation of lactate within the bloodstream, which is likely attributable to the impaired peripheral tissue perfusion. In MMVD dogs, blood lactate may be used as a surrogate for cardiac remodeling, and an increased concentration is associated with a worse prognosis regarding the time to evolve into congestive heart failure. |
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Palavras-Chave: |
Blood lactate; Congestive heart failure; Doença valvula; Endocardiosis; Hiperlactatemia; Hipoperfusão; Hyperlactatemia; Hypoperfusion; Insuficiência cardíaca congestiva; Lactato sanguíneo; Mitral valve disease; Myxomatous mitral valve disease; Valvopatia mitral. |
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Thesagro: |
Cão. |
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Thesaurus Nal: |
Dogs. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/184912/1/Blood-lactate-increases-with-the-progression.pdf
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Marc: |
LEADER 02704naa a2200385 a 4500
001 2098005
005 2018-10-23
008 2018 bl uuuu u00u1 u #d
100 1 $aSILVA-FILHO, J. C.
245 $aBlood lactate increases with the progression of mitral valve disease in dogs.$h[electronic resource]
260 $c2018
500 $aTítulo em português: Aumento de lactato sanguíneo com progressão de valvopatia mitral em cães.
520 $aIn dogs with congestive heart failure, the upregulated sympathetic tone causes vasoconstriction that impairs peripheral blood supply, therefore causing the accumulation of lactate. In this prospective cross-sectional study with a longitudinal component, blood lactate was quantified in 10 healthy and 34 myxomatous mitral valve disease (MMVD) dogs to investigate its potential use as a diagnostic and prognostic biomarker. While there were no differences in lactate concentration between control animals and stages B1 (3.31±0.62mmol/L) and B2 (3.32±0.46mmol/L) dogs, significant differences were found between healthy (2.50±0.69mmol/L) and both C (3.99±0.47mmol/L) and D (6.97±1.23mmol/L) animals. When a cut-off of 3.35mmol/L was used, lactate was able to distinguish dogs with normal and remodeled hearts with a sensitivity of 78.2% and specificity of 63.6%. Also, significant correlations existed between lactate and indicators of cardiac remodeling. Finally, animals with blood lactate <3.5mmol/L carried a better prognosis when compared with dogs in which lactate was >5.0mmol/L. Our results suggest that the progression of MMVD results in accumulation of lactate within the bloodstream, which is likely attributable to the impaired peripheral tissue perfusion. In MMVD dogs, blood lactate may be used as a surrogate for cardiac remodeling, and an increased concentration is associated with a worse prognosis regarding the time to evolve into congestive heart failure.
650 $aDogs
650 $aCão
653 $aBlood lactate
653 $aCongestive heart failure
653 $aDoença valvula
653 $aEndocardiosis
653 $aHiperlactatemia
653 $aHipoperfusão
653 $aHyperlactatemia
653 $aHypoperfusion
653 $aInsuficiência cardíaca congestiva
653 $aLactato sanguíneo
653 $aMitral valve disease
653 $aMyxomatous mitral valve disease
653 $aValvopatia mitral
700 1 $aSOUSA, M. G.
700 1 $aFERREIRA, E. Z.
700 1 $aORTIZ, E. M. G.
700 1 $aFRANCO, R. P.
700 1 $aROSA, F. A.
700 1 $aCAMACHO, A. A.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 38, n. 9, p. 1781-1786, setembro 2018
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Registro original: |
Embrapa Unidades Centrais (AI-SEDE) |
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