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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
17/11/2020 |
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Data da última atualização: |
17/11/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OKINO, C. H.; BASSETTO, C. C.; GIGLIOTI, R.; SILVA, P. C.; TONELLI, M. F.; MARCONDES, C. R.; OLIVEIRA, H. N. de; OLIVEIRA, M. C. de S. |
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Afiliação: |
CINTIA HIROMI OKINO, CPPSE; César Cristiano Bassetto, UNESP; Rodrigo Giglioti, IZ; Pamella Cristini Silva, CNPq; Maria Fernanda Tonelli, FAPESP; CINTIA RIGHETTI MARCONDES, CPPSE; Henrique Nunes de Oliveira, UNESP; MARCIA CRISTINA DE SENA OLIVEIRA, CPPSE. |
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Título: |
A polymorphic CD4 epitope related to increased susceptibility to Babesia bovis in Canchim calves. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Veterinary Immunology and Immunopathology, v. 230, dec. 2020, 110132. |
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Páginas: |
7 p. |
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DOI: |
https://doi.org/10.1016/j.vetimm.2020.110132 |
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Idioma: |
Inglês |
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Conteúdo: |
Different allelic forms of bovine CD4 were previously described in cattle and were also observed in Canchim calves examined in the present experiment. However, the functional relevance of these different CD4 phenotypes has not yet been investigated. CD4 + T helper cells are known to play a central role in immune control against Babesia bovis infection. Thus, our study aimed to compare the profiles of immune cells, specific antibody titers and blood infection levels measured by qPCR (quantitative polymerase chain reaction) in calves naturally infected with B. bovis, phenotyped as CD4- (absence of anti-CD4 staining), CD4 + (intermediate staining) or CD4 ++ (high staining). The CD4 mRNA precursor was also measured in these animals. Calves with the CD4-phenotype showed higher amounts of B. bovis DNA in blood samples, compared to the other CD4 phenotypes. It was also observed that these calves with higher levels of infection had lower amounts of natural killer cells and higher expression of the CD4 gene, which can be interpreted as a compensation for the failure of the altered CD4 receptor to recognize relevant B. bovis epitopes. |
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Palavras-Chave: |
Allele; Immunophenotyping; Resistance; T helper cells. |
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Thesaurus Nal: |
Calves; Polymorphism. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02035naa a2200301 a 4500
001 2126681
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008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.vetimm.2020.110132$2DOI
100 1 $aOKINO, C. H.
245 $aA polymorphic CD4 epitope related to increased susceptibility to Babesia bovis in Canchim calves.$h[electronic resource]
260 $c2020
300 $a7 p.
520 $aDifferent allelic forms of bovine CD4 were previously described in cattle and were also observed in Canchim calves examined in the present experiment. However, the functional relevance of these different CD4 phenotypes has not yet been investigated. CD4 + T helper cells are known to play a central role in immune control against Babesia bovis infection. Thus, our study aimed to compare the profiles of immune cells, specific antibody titers and blood infection levels measured by qPCR (quantitative polymerase chain reaction) in calves naturally infected with B. bovis, phenotyped as CD4- (absence of anti-CD4 staining), CD4 + (intermediate staining) or CD4 ++ (high staining). The CD4 mRNA precursor was also measured in these animals. Calves with the CD4-phenotype showed higher amounts of B. bovis DNA in blood samples, compared to the other CD4 phenotypes. It was also observed that these calves with higher levels of infection had lower amounts of natural killer cells and higher expression of the CD4 gene, which can be interpreted as a compensation for the failure of the altered CD4 receptor to recognize relevant B. bovis epitopes.
650 $aCalves
650 $aPolymorphism
653 $aAllele
653 $aImmunophenotyping
653 $aResistance
653 $aT helper cells
700 1 $aBASSETTO, C. C.
700 1 $aGIGLIOTI, R.
700 1 $aSILVA, P. C.
700 1 $aTONELLI, M. F.
700 1 $aMARCONDES, C. R.
700 1 $aOLIVEIRA, H. N. de
700 1 $aOLIVEIRA, M. C. de S.
773 $tVeterinary Immunology and Immunopathology$gv. 230, dec. 2020, 110132.
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Embrapa Pecuária Sudeste (CPPSE) |
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| 1. |  | OLIVEIRA, H. N. de. Amigo oculto do agricultor. Safra: Revista do Agronegócio, ano 10, n. 118, p. 41, nov. 2009. SIDE 022/09A - Agroline, 18 ago. 2009; SIDE 022/09B - Diário MS, 6 ago. 2009; SIDE 022/09C - Infobibos 2009; SIDE 022/09D - Diário MS 06 ago. 2009; SIDE 022/09E - 06 ago. 2009; SIDE 022/09F - Dourados News, 06 ago 2009; SIDE 022/09G -...| Tipo: Artigo de Divulgação na Mídia |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 3. | | OLIVEIRA, H. N. de. Controle biológico de insetos. In: PEZARICO, C. R.; RETORE, M. (Ed.). Tecnologias para a agricultura familiar. 3. ed. rev. e atual. Dourados: Embrapa Agropecuária Oeste, 2018. il. color. (Embrapa Agropecuária Oeste. Documentos, 122). p. 121-124| Tipo: Capítulo em Livro Técnico-Científico |
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